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Test of the Free Fraction model based on the 300 mcg/day Intrinsa T Patch* Change in Total T:
Change in Free T:
1000
100.0 Transdermal E2
Oral CEE
Free Fraction
Power (All)
100
10.0
10
1.0 y = 14.789x
Transdermal E2
Oral CEE
Free Fraction
Power (All)
-0.4148
y = 27.43x
0.2903
R
2
R = 0.1411 Change in Total T (ng/dL)
2
= 0.1652
Change in Free T (pg/mL) 0.1
1 10
100 SHBG (nmole/Liter)
1000
10
100 SHBG (nmole/Liter)
* Data from Mazer & Shifren, Ob Gyn Survey 2003
1000
Change in Free T:
1000
100.0 Transdermal E2
Oral CEE
Free Fraction
Power (All)
100
10.0
10
1.0 y = 14.789x
Transdermal E2
Oral CEE
Free Fraction
Power (All)
-0.4148
y = 27.43x
0.2903
R
2
R = 0.1411 Change in Total T (ng/dL)
2
= 0.1652
Change in Free T (pg/mL) 0.1
1 10
100 SHBG (nmole/Liter)
1000
10
100 SHBG (nmole/Liter)
* Data from Mazer & Shifren, Ob Gyn Survey 2003
1000
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