Safc Biosciences - Development Services
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Process Development
Research
Development Services Everything you need – at every stage of development
www.safcbiosciences.com
Member of the Sigma-Aldrich Group
Taking the guesswork out of cell line development
Trust SAFC Biosciences to accelerate the pre-clinical stages of your development processes.
Cell Xpress™ Clone Selection
Molecular Biology Consultation and Services
Absolute: Analyze, select, document and perpetuate only the clones that meet your development criteria in just weeks, cutting cell line development timelines in half.
Wisdom: Choose SAFC Biosciences and expect high performance products, services and information – all designed to enable you to quickly select the best possible option to meet your research goals.
• Technology for single-cell cloning of the most productive clones in a population
• Expression feasibility
- Increase specific productivity and titer
- Secretion assessment - Expression strategies
- Stabilize cell line genetic drift
• Transfection optimization
- Create clones that are more uniform in productivity
- Improved methodology - Optoinjection
Extend your capabilities with a full line of development services
Molecular Biology Consultation and Services
Gene of Interest
Media Optimization and Adaptation
Process Development
Scale-up & Validation Studies
time
Clone Selection (Cell Xpress™)
Stability Assessment
Process Feasibility
Product
Responsive Expertise SAFC Biosciences is the world’s leading supplier of cell culture reagents to producers of marketed biological products. We are committed to supplying high-quality critical raw materials and specialized cell culture products and services to the global health care industry. By providing the broadest range of highly customized products and services possible to cell culture-based manufacturing companies we demonstrate our commitment to being responsive experts.
Facilitate decisions with feasibility analysis
Cut cell line development in half with Cell Xpress™
Meet your research goals Add control to your biological processes
Benefit from 35 years' experience in media optimization
Achieve consistent development results through stability assessment
Increase your specific productivity and titer with Cell Xpress™ Cell Line Development
Parental Cell Line
Commercial cell line pre-Cell XpressTM
Cell Xpress™ clone
Commercial cell line 50 doublings post-Cell XpressTM
Medium Optimization and Adaptation
Stability Assessment
Proven: Benefit from over 35 years’ expertise in successfully optimizing media component composition for increased productivity and overall robustness in the cell culture process.
Consistent: As your chosen manufacturer and supply partner, we understand that material and processes must be carefully and proactively managed to ensure consistent performance and manage product risk.
• Statistical Approaches - Mixture experiments - Factorial matrices - Central composite designs • Rational Design Approaches
• Cell line stability - Generational consistency studies - Visual analysis of clone performance at any stage • Media stability
- Spent medium analysis (amino acids, glutamine, lactate, etc.)
- Fresh and spent media analysis
- New assay development (vitamins, fatty acids, biomarkers, trace elements, peptide mapping, etc.)
- Experience with serum-free, animal-component free, protein-free and chemically defined media formulations • Component analysis
Using our computer-aided cell screening, photographic analysis, laser-based selection and rapid media optimization techniques, you will find we remove any need for guesswork.
Process Development
Scale-Up and Validation
Powerful: Harness our scientific, technical and commercial knowledge for scaleable, application-tested cell culture solutions for expression of your proteins.
Simple: SAFC Biosciences adds control to biological processes through customized projects and investigations of all potential sources of performance or quality variation.
• Bioreactor scale feasibility
• Extensive library of cell culture products
- Process control - Development of bioreactor processes - Feed strategies - Value-added feeds/supplements (optimized hydrolysates) - Contract projects • Feed development - Amino acids - Vitamins
- Consistent performance - Scaleable • Quantification of components in fresh or spent media • Monitoring productivity during process optimization • Characterizing product quality • Customized assays • Upstream & downstream biological buffers
- Hydrolysates - Productivity inducers • imMEDIAte ADVANTAGE™ - 10-day turnaround on custom media formulations - Standardized raw materials - Mirrors manufacturing methods in large-scale cGMP facilities
Facilitate decisions with feasibility analysis
Contact us United States SAFC Biosciences, Inc. 13804 W. 107th Street Lenexa, Kansas 66215 USA Tel: +1 913-469-5580 Toll Free – USA: 1 800-255-6032 Fax: +1 913-469-5584 E-mail: [email protected]
Europe SAFC Biosciences Ltd. Smeaton Road, West Portway Andover, Hampshire SP10 3LF UNITED KINGDOM Tel: +44 (0)1264-333311 Fax: +44 (0)1264-332412 E-mail: [email protected]
Asia Pacific SAFC Biosciences Pty. Ltd. 18-20 Export Drive Brooklyn, Victoria 3025 AUSTRALIA Tel: +61 (0)3-9362-4500 Toll Free – AUS: 1 800-200-404 Fax: +61 (0)3-9315-1656 E-mail: [email protected]
imMEDIAte ADVANTAGE™ is a trademark of SAFC Biosciences, Inc. Cell Xpress™ is a trademark of Cyntellect. © 2007 SAFC Biosciences, Inc. Issued January 2007 G055
www.safcbiosciences.com
Member of the Sigma-Aldrich Group
Research
Development Services Everything you need – at every stage of development
www.safcbiosciences.com
Member of the Sigma-Aldrich Group
Taking the guesswork out of cell line development
Trust SAFC Biosciences to accelerate the pre-clinical stages of your development processes.
Cell Xpress™ Clone Selection
Molecular Biology Consultation and Services
Absolute: Analyze, select, document and perpetuate only the clones that meet your development criteria in just weeks, cutting cell line development timelines in half.
Wisdom: Choose SAFC Biosciences and expect high performance products, services and information – all designed to enable you to quickly select the best possible option to meet your research goals.
• Technology for single-cell cloning of the most productive clones in a population
• Expression feasibility
- Increase specific productivity and titer
- Secretion assessment - Expression strategies
- Stabilize cell line genetic drift
• Transfection optimization
- Create clones that are more uniform in productivity
- Improved methodology - Optoinjection
Extend your capabilities with a full line of development services
Molecular Biology Consultation and Services
Gene of Interest
Media Optimization and Adaptation
Process Development
Scale-up & Validation Studies
time
Clone Selection (Cell Xpress™)
Stability Assessment
Process Feasibility
Product
Responsive Expertise SAFC Biosciences is the world’s leading supplier of cell culture reagents to producers of marketed biological products. We are committed to supplying high-quality critical raw materials and specialized cell culture products and services to the global health care industry. By providing the broadest range of highly customized products and services possible to cell culture-based manufacturing companies we demonstrate our commitment to being responsive experts.
Facilitate decisions with feasibility analysis
Cut cell line development in half with Cell Xpress™
Meet your research goals Add control to your biological processes
Benefit from 35 years' experience in media optimization
Achieve consistent development results through stability assessment
Increase your specific productivity and titer with Cell Xpress™ Cell Line Development
Parental Cell Line
Commercial cell line pre-Cell XpressTM
Cell Xpress™ clone
Commercial cell line 50 doublings post-Cell XpressTM
Medium Optimization and Adaptation
Stability Assessment
Proven: Benefit from over 35 years’ expertise in successfully optimizing media component composition for increased productivity and overall robustness in the cell culture process.
Consistent: As your chosen manufacturer and supply partner, we understand that material and processes must be carefully and proactively managed to ensure consistent performance and manage product risk.
• Statistical Approaches - Mixture experiments - Factorial matrices - Central composite designs • Rational Design Approaches
• Cell line stability - Generational consistency studies - Visual analysis of clone performance at any stage • Media stability
- Spent medium analysis (amino acids, glutamine, lactate, etc.)
- Fresh and spent media analysis
- New assay development (vitamins, fatty acids, biomarkers, trace elements, peptide mapping, etc.)
- Experience with serum-free, animal-component free, protein-free and chemically defined media formulations • Component analysis
Using our computer-aided cell screening, photographic analysis, laser-based selection and rapid media optimization techniques, you will find we remove any need for guesswork.
Process Development
Scale-Up and Validation
Powerful: Harness our scientific, technical and commercial knowledge for scaleable, application-tested cell culture solutions for expression of your proteins.
Simple: SAFC Biosciences adds control to biological processes through customized projects and investigations of all potential sources of performance or quality variation.
• Bioreactor scale feasibility
• Extensive library of cell culture products
- Process control - Development of bioreactor processes - Feed strategies - Value-added feeds/supplements (optimized hydrolysates) - Contract projects • Feed development - Amino acids - Vitamins
- Consistent performance - Scaleable • Quantification of components in fresh or spent media • Monitoring productivity during process optimization • Characterizing product quality • Customized assays • Upstream & downstream biological buffers
- Hydrolysates - Productivity inducers • imMEDIAte ADVANTAGE™ - 10-day turnaround on custom media formulations - Standardized raw materials - Mirrors manufacturing methods in large-scale cGMP facilities
Facilitate decisions with feasibility analysis
Contact us United States SAFC Biosciences, Inc. 13804 W. 107th Street Lenexa, Kansas 66215 USA Tel: +1 913-469-5580 Toll Free – USA: 1 800-255-6032 Fax: +1 913-469-5584 E-mail: [email protected]
Europe SAFC Biosciences Ltd. Smeaton Road, West Portway Andover, Hampshire SP10 3LF UNITED KINGDOM Tel: +44 (0)1264-333311 Fax: +44 (0)1264-332412 E-mail: [email protected]
Asia Pacific SAFC Biosciences Pty. Ltd. 18-20 Export Drive Brooklyn, Victoria 3025 AUSTRALIA Tel: +61 (0)3-9362-4500 Toll Free – AUS: 1 800-200-404 Fax: +61 (0)3-9315-1656 E-mail: [email protected]
imMEDIAte ADVANTAGE™ is a trademark of SAFC Biosciences, Inc. Cell Xpress™ is a trademark of Cyntellect. © 2007 SAFC Biosciences, Inc. Issued January 2007 G055
www.safcbiosciences.com
Member of the Sigma-Aldrich Group
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