Rohit Shah Ty Bpharm
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Seminar on HEPATOCELLULAR CARCINOMA BY ROHIT M SHAH
CANCER characterized by : uncontrolled growth Spread of abnormal cells
Tumors are of different origin and are distinguish accordingly » Carcinoma » Sarcoma » Leukemia » Lymphoma » Myelomas
HEPATOCELLULAR CARCINOMA • Primary malignancy of hepatocyte
SYMTOMS • • • • • •
Pruritis Variceal bleeding Hepatic encephalopathy Jaundice Advancing cirrhossis Ascites
CAUSES • Alcohol • • • •
Hepatitis C Virus Hepatitis B Virus Hemochromatosis Aflatoxin
• DIAGNOSIS • BLOOD TEST • Alfa-fetoprotein • Albumin • Prothrombin
• IMAGING STUDIES • Ultrasonagraphy • CT scanning • Radiography
• BIOPSY
TREATMENT •MEDICAL 3.Systemic chemotherapy 4.Chemoembolizaton
•SURGICAL 6.Partial hepatectomy 7.Transplantation 8.Local tumor ablation 9.Cyberknife system
DRUG USED • DOXORUBICIN. • CLISPLATIN. • 5-FLUOURACIL.
STRATEGIES AND DELIVERY SYSTEM FOR HEPATOCELLULAR CARCINOMA BARRIERS IN TUMOR-DIRECTED STRATEGIES FOR TREATMENT OF HCC • Pysiological • Cellular • Pharmacokinectic
• STRATEGIES FOR DRUG TARGETING IN TREATMENT OF HCC • ENHANCED PERMEABILITY RETENTION EFFECT • Retention of polymeric drugs is greatly enhanced in tumor tissue
2.TUMOR pH MEDIATED TARGETING pH of solid tumor ranges from 5.7-7.8
3. HEAT MEDIATED DRUG TARGETING • Also called Hyperthermia used to modify local tumor
4. Ligand-Targeted therapeutics in anti cancer for HCC
• 5. ANTIBODIES OR LIGAND FOR SURFACE ANTIGENS EXPRESSED IN HCC CELLS • 6. GROWTH FACTOR TARGETING FOR THE TREATMENT OF HCC • 7. VEGF RECEPTOR TARGETING • 8.MAXIMIZING LIVER UPTAKE OF DRUGS CARRIERS IN TARGETING
CANCER characterized by : uncontrolled growth Spread of abnormal cells
Tumors are of different origin and are distinguish accordingly » Carcinoma » Sarcoma » Leukemia » Lymphoma » Myelomas
HEPATOCELLULAR CARCINOMA • Primary malignancy of hepatocyte
SYMTOMS • • • • • •
Pruritis Variceal bleeding Hepatic encephalopathy Jaundice Advancing cirrhossis Ascites
CAUSES • Alcohol • • • •
Hepatitis C Virus Hepatitis B Virus Hemochromatosis Aflatoxin
• DIAGNOSIS • BLOOD TEST • Alfa-fetoprotein • Albumin • Prothrombin
• IMAGING STUDIES • Ultrasonagraphy • CT scanning • Radiography
• BIOPSY
TREATMENT •MEDICAL 3.Systemic chemotherapy 4.Chemoembolizaton
•SURGICAL 6.Partial hepatectomy 7.Transplantation 8.Local tumor ablation 9.Cyberknife system
DRUG USED • DOXORUBICIN. • CLISPLATIN. • 5-FLUOURACIL.
STRATEGIES AND DELIVERY SYSTEM FOR HEPATOCELLULAR CARCINOMA BARRIERS IN TUMOR-DIRECTED STRATEGIES FOR TREATMENT OF HCC • Pysiological • Cellular • Pharmacokinectic
• STRATEGIES FOR DRUG TARGETING IN TREATMENT OF HCC • ENHANCED PERMEABILITY RETENTION EFFECT • Retention of polymeric drugs is greatly enhanced in tumor tissue
2.TUMOR pH MEDIATED TARGETING pH of solid tumor ranges from 5.7-7.8
3. HEAT MEDIATED DRUG TARGETING • Also called Hyperthermia used to modify local tumor
4. Ligand-Targeted therapeutics in anti cancer for HCC
• 5. ANTIBODIES OR LIGAND FOR SURFACE ANTIGENS EXPRESSED IN HCC CELLS • 6. GROWTH FACTOR TARGETING FOR THE TREATMENT OF HCC • 7. VEGF RECEPTOR TARGETING • 8.MAXIMIZING LIVER UPTAKE OF DRUGS CARRIERS IN TARGETING
