Ribosome(brief Summary)
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Ribosome A brief summary
Classification • According to The relation with ER: •
Free ribosome ： dissociate in the cytoplasm • Fixed ribosome: ： bind to endoplasmic reticulum
Four positive site of ribosome The place for 2 amino acid form a bond
Provide the energy for the aminoacyl-tRNA movement from A site to P site
T factor
P 5
，
site
G site
A site
3
，
mRNA
The organization of ribosome 28S RNA 5.8S RNA 60S 80S
5S RNA 18S RNA
40S
+~45 kinds protein
+ ~33 kinds protein
Genetic code • Start codon (AUG) • Stop codon ( UGA, UAA, UAG) • Degenerate: Since there are only 20 amino acids and 64 possible codons , most amino acids are specified by more than one codon; hence the code is said to be degenerate.
mRNA
Signal theory for the translocation of protein 1.Translation complex formed
ribosome signal sequence of emerging protein
translocon
SRP (signal recognition particle) 2. Recognition between SRP and signal sequence
SRP receptor
3.The recognition between SRP and SRP-R
4.Protein channel formed
5.Proteins fall into ER
Classification • According to The relation with ER: •
Free ribosome ： dissociate in the cytoplasm • Fixed ribosome: ： bind to endoplasmic reticulum
Four positive site of ribosome The place for 2 amino acid form a bond
Provide the energy for the aminoacyl-tRNA movement from A site to P site
T factor
P 5
，
site
G site
A site
3
，
mRNA
The organization of ribosome 28S RNA 5.8S RNA 60S 80S
5S RNA 18S RNA
40S
+~45 kinds protein
+ ~33 kinds protein
Genetic code • Start codon (AUG) • Stop codon ( UGA, UAA, UAG) • Degenerate: Since there are only 20 amino acids and 64 possible codons , most amino acids are specified by more than one codon; hence the code is said to be degenerate.
mRNA
Signal theory for the translocation of protein 1.Translation complex formed
ribosome signal sequence of emerging protein
translocon
SRP (signal recognition particle) 2. Recognition between SRP and signal sequence
SRP receptor
3.The recognition between SRP and SRP-R
4.Protein channel formed
5.Proteins fall into ER
