Research Summery
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I have worked in the following projects and so many drugs such as Amino Quinuride,Darunavir,Rosiglitasone,Atazanavir .And also worked to synthesize Drug intermediates like cytosine, Atazanavir Impurities,Nedolol Impurities,Fexofenadine intermediates and impurities. RESEARCH PROJECT-1
Ethidium bromide is an intercalating agent commonly used as a nucleic acid stain in molecular biology laboratories for techniques such as agarose gel electrophoresis.When exposed to ultraviolet it will fluoresce with a red orange color intensifying almost 20-fold after binding to DNA .Ethidium bromide may be a very strong mutagen. It may also be a carcinogen or teratogen although this has never been definitively proven.
NH2
H2N N C2H5Br
Ph
As with most fluorescent compounds ,ethidium bromide is aromatic.Its core heterocyclic moiety is generically known as a phenanthridine, an isomer of Which is the fluorescent dye acridine. Synthesis: NH2 NO2
NO2
O2N
NO2 H2 N
H2 N
O2N NO2
O2N Ph
N
Ph
C 2 H5
NH2
H 2N Ph
N C2H5Br
NO2
NO2
O2N N
O
HN C Ph
RESEARCH SUMMARY-2
CORGARD (nadolol) is a synthetic nonselective beta-adrenergic receptor blocking agent designated chemically as 1-(tertbutylamino)-3-[(5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1- naphthyl)oxy]-2-propanol. Structural formula:
C17H27NO4 MW 309.40 Nadolol is a white crystalline powder. It is freely soluble in ethanol, soluble in hydrochloric acid, slightly soluble in water and in chloroform, and very slightly soluble in sodium hydroxide.
Synthesis: OH
OH
OH
OH
O
HO
O HO
O HO HO
OH
N H
O O O
OH
N H
O O O
O
RESEARCH SUMMARY-3
Fexofenadine hydrochloride, the active ingredient . It is anti histamine drug used in the treatment of hayfever and similar allergy symptoms. It works by being an antagonist to the H1 receptor. with the chemical name (±)-4-[1 hydroxy-4-[4(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-α, α-dimethyl benzeneacetic acid hydrochloride.It has the following chemical structure
OH
H3C N
COOH CH3
HCl
OH
The molecular weight is 538.13 and the empirical formula is C32H39NO4•HCl Fexofenadine hydrochloride is a white to off white crystalline power.It is freely soluble in methanol and ethanol , slightly soluble in chloroform and water .
SYNTHESIS: OH H3C OH + HN
OH
COOCH3 H3C
CH3 Cl
N
COOCH3 CH3
O
H3 C N
COOCH3 CH3
O OH
OH
OH
H3C N
COOH CH3
OH
HCl
H3C N
COOH CH3
OH
RESEARCH SUMMARY-4
Nedolol Impurities:1. O
NH
NH
O
OH
1-tert Butylamino-3-(napthalene-1-yloxy)-propan-2-ol MW=273.37
OH
5-(3,1-dimethylethyl)amino)-2-hydroxypropoxy)1,2,3,4 tetrahydro-napthalene MW=277.40
OH
OCH3
O HO
O OH
HO
HO
OH
HO 5-(2,3 Dihydroxy-propoxy)-1,2,3,4-tetrahydro napthalene-2,3 diol MW=254.28
O HO
Methoxy impurity
O OH
OH OH
HO Penta hydroxy impurity
O HO
N OH
O OH
HO
OH OH
Dimer impurity
Ethidium bromide is an intercalating agent commonly used as a nucleic acid stain in molecular biology laboratories for techniques such as agarose gel electrophoresis.When exposed to ultraviolet it will fluoresce with a red orange color intensifying almost 20-fold after binding to DNA .Ethidium bromide may be a very strong mutagen. It may also be a carcinogen or teratogen although this has never been definitively proven.
NH2
H2N N C2H5Br
Ph
As with most fluorescent compounds ,ethidium bromide is aromatic.Its core heterocyclic moiety is generically known as a phenanthridine, an isomer of Which is the fluorescent dye acridine. Synthesis: NH2 NO2
NO2
O2N
NO2 H2 N
H2 N
O2N NO2
O2N Ph
N
Ph
C 2 H5
NH2
H 2N Ph
N C2H5Br
NO2
NO2
O2N N
O
HN C Ph
RESEARCH SUMMARY-2
CORGARD (nadolol) is a synthetic nonselective beta-adrenergic receptor blocking agent designated chemically as 1-(tertbutylamino)-3-[(5,6,7,8-tetrahydro-cis-6,7-dihydroxy-1- naphthyl)oxy]-2-propanol. Structural formula:
C17H27NO4 MW 309.40 Nadolol is a white crystalline powder. It is freely soluble in ethanol, soluble in hydrochloric acid, slightly soluble in water and in chloroform, and very slightly soluble in sodium hydroxide.
Synthesis: OH
OH
OH
OH
O
HO
O HO
O HO HO
OH
N H
O O O
OH
N H
O O O
O
RESEARCH SUMMARY-3
Fexofenadine hydrochloride, the active ingredient . It is anti histamine drug used in the treatment of hayfever and similar allergy symptoms. It works by being an antagonist to the H1 receptor. with the chemical name (±)-4-[1 hydroxy-4-[4(hydroxydiphenylmethyl)-1-piperidinyl]-butyl]-α, α-dimethyl benzeneacetic acid hydrochloride.It has the following chemical structure
OH
H3C N
COOH CH3
HCl
OH
The molecular weight is 538.13 and the empirical formula is C32H39NO4•HCl Fexofenadine hydrochloride is a white to off white crystalline power.It is freely soluble in methanol and ethanol , slightly soluble in chloroform and water .
SYNTHESIS: OH H3C OH + HN
OH
COOCH3 H3C
CH3 Cl
N
COOCH3 CH3
O
H3 C N
COOCH3 CH3
O OH
OH
OH
H3C N
COOH CH3
OH
HCl
H3C N
COOH CH3
OH
RESEARCH SUMMARY-4
Nedolol Impurities:1. O
NH
NH
O
OH
1-tert Butylamino-3-(napthalene-1-yloxy)-propan-2-ol MW=273.37
OH
5-(3,1-dimethylethyl)amino)-2-hydroxypropoxy)1,2,3,4 tetrahydro-napthalene MW=277.40
OH
OCH3
O HO
O OH
HO
HO
OH
HO 5-(2,3 Dihydroxy-propoxy)-1,2,3,4-tetrahydro napthalene-2,3 diol MW=254.28
O HO
Methoxy impurity
O OH
OH OH
HO Penta hydroxy impurity
O HO
N OH
O OH
HO
OH OH
Dimer impurity
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