Pulsatile Drug Delivery

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INTRODUCTION CIRCADIAN RHYTHM CHRONOPHARMACEUTICAL ACTIVE AGENT METHODOLOGIES FOR PULSATILE SYSTEM

RECENT ADVANNCES MARKETED EXAMPALES CONCLUSION REFERENCES ‡

Y  Pulsed or Pulsatile drug release is defined as the rapid and transient release of certain amount of drug molecules within a short time of period immidietly after a predetermined off release period.

  ! Pulsatile drug delivery system is to achieve the chronotherapy„

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eptic ulcer pilepsy Osteoarthritis

Sleep disorder Aponea Asthma

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Theophylline

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Uniphyl; extended tablets

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CONTIN

Asthma/increased bronchoconstriction in morning

release

Oct. 15, 1986

Famotidine

Pepcid; tablets

Physico-chemical modification of API

Ulcer/increased gastric acid secretion in evening

Dec. 23, 1991

›imvastatin

Zocor; Tablets

Physico-chemical modification of API

Hypercholesterolemia /increased cholesterol synthesis overnight

Feb. 26, 1996

Verapamil HCl

Covera-H›; extended release tablets

ORO›

Hypertension/increase d BP early morning

Nov. 25, 1998

Verapamil HCl

Verelan PM; extended CODA› release capsules

Hypertension

Feb. 06, 2003

Diltiazem HCl verapamil HCl

Cardizem extended release tablets

LA; CEFORM

Hypertension

Mar. 12, 2003

Propranolol HCl verapamil HCl

InnoPran extended release capsules

XL DIFFUCAP›

Hypertension

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1. Howard N. E. ›tevens: Pulsincap and hydrophilic sandwitch capsules, Modified Release Drug Delivery Technology, Vol.126, Marcel Dekker, Inc., 257-261 2. Arora ›, Ali.J, Ahuje.A: Pulsatile drug delivery systems: An approach for controlled drug delivery, Indian J. Pharm. ›ci., 2006, 68(3): 295-300. 3. Bussemer.T, Roland B: Multiparticulate Pulsatile Drug delivery ›ystems, Microencapsulation Methods and Industrial Applications Ed.2 Edited by: ›imon Benita. Published by: Taylor and Francis. 79-84 4. A.V. Gothoskar, A.M. Joshi, and N.H. Joshi, Pulsatile Drug Delivery ›ystems: A Review, www.drugdeliverytech.com 5. #& 2 ›2#% Colon Targeted Pulsatile Drug Delivery : A Review; Indian J. Pharm. ›ci., 2007, 45(3): 95-100. 6. ›risagul ›ungthongjeen, ›atit Puttipipatkhachorn, Ornlaksana Paeratakul, Andrei Dashevsky and Roland Bodmeier : Development of pulsatile release tablets with swelling and rupturable layers, Journal of Controlled Release, 2004, 95(2): 147-159 7. Veena › Belgamwar, Madhuri V Gaikwad, Ganesh B Patil, ›anjay ›urana; Pulsatile drug delivery system; Asian Journal of Pharmaceutics - July-›eptember 2008 8. ›achin ›urvase and Neeraj Kumar; PUL›ATILE DRUG DELIVERY: CURREN ›CENARIO; j. of Current Research & Information on Pharmaceutical ›ciences 2008 88(7), 56-66. (


11. Till Bussemer, Roland A. Bodmeier; Drug Delivery: Pulsatile ›ystems; Encyclopedia of PHARMACEUTICAL TECHNOLOGY; Editor - James ›warbrick, Third Edition ; VOLUME 2 1297-1320. 12. Andrea Gazzaniga *, Luca Palugan, Anastasia Foppoli, Maria Edvige ›angalli; Oral pulsatile delivery systems based on swellable hydrophilic polymers; European Journal of Pharmaceutics and Biopharmaceutics 68 (2008) 11±18 13. Bin Li, JiaBi Zhu, ChunLi Zheng, Wen Gong; A novel system for three-pulse drug release based on ³tablets in capsule´ device; International Journal of Pharmaceutics 352 (2008) 159±164. 14. Yao LIU, ›ongqing LIU,* and Qing DAI; Design and Evaluation of pH-Independent Pulsatile Release Pellets Containing Isosorbide-5-mononitrate; Chem. Pharm. Bull. 57(1) (2009) 55²60 15. Vijaya Kumar B* , Nagaraj B , Agaiah B , Rambhau D ; Design and In Vitro Evaluation of Chrono Modulated Theophylline Tablets ›. J. Pharm. ›ci. 1(1&2): 25-28 16. Andrei Dashevsky, Ahmad Mohamad; Development of pulsatile multiparticulate drug delivery system coated with aqueous dispersion Aquacoat® ECD; International Journal of Pharmaceutics 318 (2006) 124±131 17. Bi-Botti C. Youan; Chronopharmaceutics: gimmick or clinically relevant approach to drug delivery?; Journal of Controlled Release 98 (2004) 337± 353. 18. Nitin ›. ›atarkar, J. Zach Hilt; Magnetic hydrogel nanocomposites for remote controlled pulsatile drug release; Journal of Controlled Release 130 (2008) 246±251. ("

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