Proteins

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Biology 301 Cellular and Molecular Biology Fall 2002

Lecture # 4: Proteins

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Overall outline  Protein Function  Protein Chemistry  Protein Structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Protein Function  Protein Functions

Protein Functions

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Protein Chemistry  Synthesis of polymers  Breakdown of polymers  Amino acid structure  Amino acid titration curve  Amino acid classification  Hydrophobic amino acids  Charged amino acids  Polar amino acids  Amino acid isoelectric point  The peptide bond  Peptide bond synthesis

Synthesis of Polymers

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Breakdown of Polymers

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Amino acid structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Amino acid titration curve

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Amino acid classification • Twenty amino acids • Hydrophilic vs. hydrophobic • Charged vs. Polar

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Hydrophobic amino acids

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Polar amino acids

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Charged amino acids

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Amino acid isoelectric point

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

The peptide bond

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Peptide bond synthesis

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Protein Structure  Functional Conformation  Principles of protein structure  Primary structure  Secondary structure  Tertiary structure  Bonds contributing to tertiary structure  Hydrophobic effect  Quarternary structure  Review: Four levels of protein structure  Protein folding  Back to function

Functional Conformation

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Principles of protein structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Primary structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Secondary structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Tertiary structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Bonds contributing to tertiary structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Hydrophobic effect

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Quarternary structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Review: Four levels of protein structure

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Protein folding

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University

Back to function

Ogan Gurel, MD Biology 301 Lecture #4 Roosevelt University