Poxvirus: Family Includes: Smallpox Virus (variola Virus) Vaccinia Virus Molluscum Contagiosum Virus
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Poxvirus ► Family
includes:
► Smallpox ► Vaccinia
virus (Variola virus)
virus
► Molluscum
contagiosum virus
Smallpox virus ► Small ► Last
pox is eradicated from the earth.
case in somalia in 1977.
► Eradication
possible: Single stable serotype, No animal reservoir, easy clinical diagnosis, no subclinical or carrier state.
►
Vaccine contains live attenuated vaccinia virus.
Molluscum contagiosum virus ►A
member of pox family
► Transmitted
by close personal contact &
sexually. ► Causes
small, pink, papular, wartlike benign tumors of skin.
► No
vaccine.
DNA Non Enveloped Virus
DNA Non Enveloped Virus ► Non
enveloped DNA virus include: Adenovirus Papillomavirus Parvovirus B19
Adenovirus
Adenovirus ► Non
enveloped ds DNA virus.
► Contains
protruding fibers which helps in attachment & are hemagglutinin.
► There
are 41 known antigenic types.
Adenovirus ► Transmission:
Through aerosol droplet, fecal-oral, and direct inoculation into conjunctiva.
► Clinical ► Type
findings:
- 3, 4, 7 & 21 cause respiratory tract infection: fever, sorethroat, coyza, bronchitis & atypical pneumonia.
Adenovirus ► Type-
8 & 19 cause keratocojunctivitis.
► Type-
11& 21 cause hemorrhagic cystitis.
► Type-
40 & 41 cause infantile gastroenteritis with nonbloody diarrhea.
Adenovirus ► Isolation
of virus by culture.
► Serological
test: Antibody titer ( 4 fold rise), complement fixation test & hemagglutination inhibition test.
Papillomavirus
Papillomavirus ► Nonenveloped,
ds DNA virus.
► There
at least 100 types of papillomavirus.
► Some
causes malignancies.
► Malignancy
is associated with E6 & E7 genes, encodes p53 & retinoblastoma genes respectively.
Papillomavirus ► Transmission:
Primarily occurs by direct contact and sexually. ► Clinical findings: ► HPV cause benign tumors (wart) on the skin. ► HPV1, 2, 3 & 4 cause skin & planter wart. ► HPV6 & HPV 11 cause genital wart. ► HPV 16 & HPV 18 are associated with carcinoma of cervix, penis & anus.
Papillomavirus ► Lab
diagnosis:
► Mainly ► DNA
diagnosed by clinical ground.
hybridization test is also available.
Parvovirus
General properties ► Smallest,
SS DNA virus.
► Non-enveloped. ► Associated
with Transient aplastic crisis in patients with sickle cell disease, erythema infectiosum and congenital infections.
Parvovirus ► Parvovirus B-19 - only human pathogen ► Transmission: Occurs through respiratory
droplet, placenta & blood transfusion
Clinical significance... ► Erythema
infectiosum ( fifth disease) ► Aplastic anemia. ► Congenital infections spontaneous abortion - ( first trimester) Hydrops fetalis ( 2nd or 3rd trimester)
includes:
► Smallpox ► Vaccinia
virus (Variola virus)
virus
► Molluscum
contagiosum virus
Smallpox virus ► Small ► Last
pox is eradicated from the earth.
case in somalia in 1977.
► Eradication
possible: Single stable serotype, No animal reservoir, easy clinical diagnosis, no subclinical or carrier state.
►
Vaccine contains live attenuated vaccinia virus.
Molluscum contagiosum virus ►A
member of pox family
► Transmitted
by close personal contact &
sexually. ► Causes
small, pink, papular, wartlike benign tumors of skin.
► No
vaccine.
DNA Non Enveloped Virus
DNA Non Enveloped Virus ► Non
enveloped DNA virus include: Adenovirus Papillomavirus Parvovirus B19
Adenovirus
Adenovirus ► Non
enveloped ds DNA virus.
► Contains
protruding fibers which helps in attachment & are hemagglutinin.
► There
are 41 known antigenic types.
Adenovirus ► Transmission:
Through aerosol droplet, fecal-oral, and direct inoculation into conjunctiva.
► Clinical ► Type
findings:
- 3, 4, 7 & 21 cause respiratory tract infection: fever, sorethroat, coyza, bronchitis & atypical pneumonia.
Adenovirus ► Type-
8 & 19 cause keratocojunctivitis.
► Type-
11& 21 cause hemorrhagic cystitis.
► Type-
40 & 41 cause infantile gastroenteritis with nonbloody diarrhea.
Adenovirus ► Isolation
of virus by culture.
► Serological
test: Antibody titer ( 4 fold rise), complement fixation test & hemagglutination inhibition test.
Papillomavirus
Papillomavirus ► Nonenveloped,
ds DNA virus.
► There
at least 100 types of papillomavirus.
► Some
causes malignancies.
► Malignancy
is associated with E6 & E7 genes, encodes p53 & retinoblastoma genes respectively.
Papillomavirus ► Transmission:
Primarily occurs by direct contact and sexually. ► Clinical findings: ► HPV cause benign tumors (wart) on the skin. ► HPV1, 2, 3 & 4 cause skin & planter wart. ► HPV6 & HPV 11 cause genital wart. ► HPV 16 & HPV 18 are associated with carcinoma of cervix, penis & anus.
Papillomavirus ► Lab
diagnosis:
► Mainly ► DNA
diagnosed by clinical ground.
hybridization test is also available.
Parvovirus
General properties ► Smallest,
SS DNA virus.
► Non-enveloped. ► Associated
with Transient aplastic crisis in patients with sickle cell disease, erythema infectiosum and congenital infections.
Parvovirus ► Parvovirus B-19 - only human pathogen ► Transmission: Occurs through respiratory
droplet, placenta & blood transfusion
Clinical significance... ► Erythema
infectiosum ( fifth disease) ► Aplastic anemia. ► Congenital infections spontaneous abortion - ( first trimester) Hydrops fetalis ( 2nd or 3rd trimester)
