Pharmacology

Pharmacology Dr. Yuan Bing-Xiang Department of Pharmacology, Medical School, Xi’an Jiaotong University, Tel: 82657468, Email: [email protected]

Tool of explore life secret

Compounds

New drug

technology

Medicine ligament Pharmacology

Pharmacy

estimation

Good drug

Bad drug

Clinic Medicine bridge

Basic Medicine Basis of Therapeutics

1. General Principles 2. Peripheral Nervous Pharmacology 3. Central Nervous Pharmacology 4. Cardiovascular Pharmacology 5. Splanchnic and Blood Pharmacology 6. Endocrine Pharmacology 7. Chemotherapeutic Pharmacology

(7 parts)

Pharmacology PART 1 GENERAL PHARMACOLOGIC PRINCIPLES CHAPTER 1

Introduction of

Pharmacology CHAPTER 2 Pharmacodynamics CHAPTER 3 Pharmacokinetics CHAPTER 4 Impact factor

CHAPTER 1 Introduction of Pharmacology 【 CONCEPTION 】 【 RESEARCH METHODS OF HARMACOLOGY 】

Ⅰ CONCEPTION 1. Pharmacology

Pharmacology is the discipline studding the interaction or relationship between drugs and bodies including human being, animals and pathogens including microorganisms (bacteria, virus) , parasites and tumor cells…. Drugs is the chemicals beneficially altering biochemical and physiologic states of body, applied to prevent,

2. Two areas of pharmacology pharmacodynamics drugs

pharmacokinetics

bodies

Impact factor •Act on different systems •

human being, Animals pathogens (bacteria, virus ,

Pharmacodynamics (drugs acts on Drug body) action effects effects * beneficial or therapeutic action * untoward reaction

mechanism * drug-receptors of action * drug-ion channels * drug-enzymes * ……

Pharmacokinetics (body acts on drug) of absorption Undergoing  distribution drugs in body 

C-T curves  

excretion biotransformation

C

drug blood Concentration-Time curves pharmacokinetic parameters from the C-T curves

RESEARCH METHODS OF PHARMACOLOGY physiology, biochemistry, pathology, clinical medicine, … research methods

plus pharmacological methods

research

Method of preclinic pharmacology (The experimental object is ( healthy animals or ill animals) animals) ①waking (clear-headed) animals ②anesthetic animals ③normal or abnormal organs, tissues, cells, cell substructures and molecules ④pharmacokinetics （ C-T curves ）

Method of clinic pharmacology The experimental object is human being ( healthy volunteer and patients ） . I phase: 20-30 healthy volunteer II phase: >100 patients III phase: >300 patients IV phase: >2000 patients technology, ethics

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