Peptide Synthesis For H1n1 Cases

 

Will Killer Peptide Offer New Therapy Against Swine Flu H1N1 Virus? -From www.lifetein.com The 2009 swine flu outbreak in humans is caused by a new strain of influenza A virus subtype H1N1. The origin of this new strain is unknown, and the World Organization for Animal Health (OIE) reports that this strain has not been isolated in pigs. This is a version of swine flu hemagglutinin amino acid sequence: MKAILVVMLYTFATANADTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCK LRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETSSSDNGTCYPGDFIDYEELRE QLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSK SYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGSSRYSKKFKPEIAIRPKVRDQ EGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPK GAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNVPSIQSRGLFGAIAGFIEGGWTG MVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKR IENLNKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKVRSQLKNNAKEIGNG CFEFYHKCDNTCMESVKNGTYDYPKYSEEAKLNREEIDGVKLESTRIYQILAIYSTVASS LVLVVSLGAISFWMCSNGSLQCRICI

The H1N1 swine flu can be transmitted from human to human, and causes the normal symptoms of influenza, such as fever, coughing and headache. This has brought about new concerns of a pandemic outbreak. Although vaccination can be an effective strategy for preventing this virus, it will take at least a few months for the discovery and development of antiviral drugs. A killer decapeptide (KP) against influenza A virus and the mechanisms of actions were described by researchers. This killer decapeptide represents the functional internal image of a yeast (Pichia anomala) killer toxin that has antimicrobial and anti-human immunodeficiency virus type 1 (HIV-1) activities. After treating with a KP concentration of 4 ug/ml, the scientists observed the complete inhibition of virus particle production and a marked reduction of the synthesis of viral proteins (membrane protein and hemagglutinin, in particular).Moreover, mice infected with influenza A/NWS/33 (H1N1) virus were inoculated with KP (100 ug/mice) once a day for ten days resulting in an improved survival rate of 40% and significantly decreased viral levels in their lungs. Will this be a suggestion for treatment of H1N1 Swine Flu? It needs further study from scientist. The KP is anti-idiotypic antibody (KT-scFv) -derived peptide. Killer decapeptide exerted a strong fungicidal activity against Candida albicans, which was attributed to peptide interaction with beta-glucan. As this polysaccharide is also a critical component of the cryptococcal cell

 

 

wall, it was found to have inhibitory activity and that has a potential therapeutic effect against pathogenic microorganisms, HIV-1, and influenza A virus by different mechanisms of action. The synthetic peptides have been widely used for therapeutic peptide research. A synthetic peptide antigen corresponding to a region of the glycoprotein gp41 encoded by the env gene of HIV-2 is found to be immunologically reactive with HIV-2 specific antibodies. This is useful in assays for detection of HIV-2 infection or exposure and in compositions to elicit the production of antibodies against HIV-2 in animals including man. The specificity of peptides has tremendous clinical value and makes them very attractive therapeutics. More than 40 peptides are in the world market and about 270 peptides are in the clinical phase. In addition, more than 400 are in advanced preclinical phases worldwide. These trends suggest that the therapeutic peptide represents a novel therapeutic strategy in the clinical setting. The scientists will find out answer for this question soon: Will Killer Peptide Offer New Therapy Against Swine Flu H1N1 Virus? Reference: G. Conti, W. Magliani, S. Conti, L. Nencioni, R. Sgarbanti, A.T. Palamara, L. Polonelli. Therapeutic activity of an anti-idiotypic antibody-derived killer peptide against influenza A virus experimental infection. Antimicrobial Agents and Chemotherapy, 52. 12: 4331-4337 ### LifeTein LLC,www.lifetein.com, located in Edison, New Jersey, was founded for its global chemical, peptide and antibody services on the principles of understanding life one protein at a time for drug development and providing expert collaborative research services to the biotech and pharmaceutical industries. LifeTein is the only peptide manufacturer to have developed its own line of PeptideSynTM platform for peptide synthesis and AdjuBoosterTM for antibody production. The PeptideSynTM technology is optimized to provide continuous flow of synthesis with saved cost but maintain high quality. This PeptideSynTM technology has proven to significantly enhance the efficiency of synthesis. The AdjuBoosterTM adjuvant has proven to increase immune responses in a shorter time for our antibody services. Please email [email protected], or call (1-732-312-5852) now and learn how we can help in the development of custom peptides and antibodies for your research program!