Pediatric Antimicrobial Dosing
This document was uploaded by user and they confirmed that they have the permission to share it. If you are author or own the copyright of this book, please report to us by using this DMCA report form. Report DMCA
Overview
Download & View Pediatric Antimicrobial Dosing as PDF for free.
More details
- Words: 486
- Pages: 3
University of Maryland Medical Center Pediatric Antimicrobial Intravenous Dosing Guidelines ( > 2 kg and > 7 days old) DRUG
IV DOSE
FREQUENCY
MAX/DOSE
Amikacin*
7.5 - 10 mg/kg/dose
per renal function
N/A
Amphotericin B
0.3 – 1 mg/kg/24h
q 24 h
N/A
Ampicillin
100 – 400 mg /kg/24h
q6h
3 gm
Ampicillin/Sulbactam (Unasyn)
100 – 400 mg /kg/24h q6h (as ampicillin component)
3 gm
Azithromycin
10 mg/kg/24h Day 1 5 mg/kg/ 24h Day 2 to 5
q 24 h
500 mg
Cefazolin
50 – 100 mg /kg/24h
q8h
1 gm
Cefepime*
50 mg/kg/ dose
q8h
2 gm
Cefotetan
20 – 40 mg/kg/dose
q 12 h
2 gm
Cefoxitin
80 – 160 mg/kg/24h
q6h
2 gm
Ceftriaxone
50 – 100 mg/kg/24h
q 24 h 2 gm q 12 h (for meningitis)
Ciprofloxacin*
15 – 20 mg/kg/24h
q 12 h
400 mg
Clindamycin
25 – 40 mg/kg/24h
q6h–8h
900 mg
Doxycycline
2 – 4 mg/kg/24h
q 12 h
100 mg
Erythromycin
20 – 50 mg/kg/24h
q6h
1 gm
Fluconazole
3 – 12 mg/kg/24h
q 24 h
800 mg
Gentamicin
2.5 mg/kg/dose
per renal function
N/A
Metronidazole
30 mg/kg/24h
q6h
1 gm
Nafcillin
150 – 200 mg/kg/24h
q6h
2 gm
Penicillin G
100,000–400,000 u/kg/24h q 4 h
4 mln units
Piperacillin/Tazobactam 200 – 400 mg/kg/24h q6h (Zosyn) (as piperacillin component)
4 gm
Ticarcillin/Clavulanate (Timentin)
200 - 300 mg/kg/24h q6h (as ticarcillin component)
3 gm
TMP/SMX (Bactrim, Septra)
6 – 20 mg/kg/24h (as TMP component)
q 12 h – 6 h
N/A
Vancomycin*
10 – 15 mg/kg/24h
per renal function
N/A
*Requires ID approval. Women’s and Children’s Pharmacy
Central Pharmacy
Hours: Monday to Friday 7 am to 10 pm Saturday & Sunday 7 am to 8 pm
Telephone Number: 8- 5644 Fax Number: 8- 8474
Telephone Number 8 – 8950 Fax Number 8 - 7163 Beeper Numbers: 0847: S6U, S6D, FTN, L&D, MBU 8476: S5U, S5D, S5A, S5B, P4G Clinical Specialist Beeper: 2411 Updated 8/2000
University of Maryland Medical System Pediatric Antimicrobial ORAL Dosing Guidelines ( > 2 kg and > 7 days old) DRUG
ORAL DOSE
FREQUENCY
MAX/Dose
Amoxicillin
25 - 90 mg/kg/24h
q 12 h
875 mg
Amoxicillin/ Clavulanic Acid (Augmentin)
25 – 90 mg/kg/24h
q 12 h
875 mg
Azithromycin
5- 12 mg/kg/24h
q 24 h
500 mg
Cefpodoxime
10 mg/kg/24h
q 12 h
400 mg
Cephalexin
25 – 100 mg/kg/24h
q6h
1 gm
Ciprofloxacin
20 – 30 mg/kg/24h
q 12 h
750 mg
Clarithromycin
15 mg/kg/24h
q 12 h
500 mg
Clindamycin
10 – 30 mg/kg/day
q6h–8h
450 mg
Doxycycline
2 – 4 mg/kg/24h
q 12 h
100 mg
Erythromycin
30 – 50 mg/kg/24h (as ethylsuccinate)
q6h
800 mg
Erythromycin/ Sulfisoxazole (Pediazole)
40 – 50 mg/kg/24h q6h (as erythromycin component)
500mg
Fluconazole
3 – 12 mg/kg/24h
q 24 h
800mg
Penicillin VK
25 – 50 mg/kg/24h
q6h
500mg
TMP/SMX (Bactrim, Septra)
6 – 10 mg/kg/24h (as TMP component)
q 12 h
160 mg Updated 9/2000
IV DOSE
FREQUENCY
MAX/DOSE
Amikacin*
7.5 - 10 mg/kg/dose
per renal function
N/A
Amphotericin B
0.3 – 1 mg/kg/24h
q 24 h
N/A
Ampicillin
100 – 400 mg /kg/24h
q6h
3 gm
Ampicillin/Sulbactam (Unasyn)
100 – 400 mg /kg/24h q6h (as ampicillin component)
3 gm
Azithromycin
10 mg/kg/24h Day 1 5 mg/kg/ 24h Day 2 to 5
q 24 h
500 mg
Cefazolin
50 – 100 mg /kg/24h
q8h
1 gm
Cefepime*
50 mg/kg/ dose
q8h
2 gm
Cefotetan
20 – 40 mg/kg/dose
q 12 h
2 gm
Cefoxitin
80 – 160 mg/kg/24h
q6h
2 gm
Ceftriaxone
50 – 100 mg/kg/24h
q 24 h 2 gm q 12 h (for meningitis)
Ciprofloxacin*
15 – 20 mg/kg/24h
q 12 h
400 mg
Clindamycin
25 – 40 mg/kg/24h
q6h–8h
900 mg
Doxycycline
2 – 4 mg/kg/24h
q 12 h
100 mg
Erythromycin
20 – 50 mg/kg/24h
q6h
1 gm
Fluconazole
3 – 12 mg/kg/24h
q 24 h
800 mg
Gentamicin
2.5 mg/kg/dose
per renal function
N/A
Metronidazole
30 mg/kg/24h
q6h
1 gm
Nafcillin
150 – 200 mg/kg/24h
q6h
2 gm
Penicillin G
100,000–400,000 u/kg/24h q 4 h
4 mln units
Piperacillin/Tazobactam 200 – 400 mg/kg/24h q6h (Zosyn) (as piperacillin component)
4 gm
Ticarcillin/Clavulanate (Timentin)
200 - 300 mg/kg/24h q6h (as ticarcillin component)
3 gm
TMP/SMX (Bactrim, Septra)
6 – 20 mg/kg/24h (as TMP component)
q 12 h – 6 h
N/A
Vancomycin*
10 – 15 mg/kg/24h
per renal function
N/A
*Requires ID approval. Women’s and Children’s Pharmacy
Central Pharmacy
Hours: Monday to Friday 7 am to 10 pm Saturday & Sunday 7 am to 8 pm
Telephone Number: 8- 5644 Fax Number: 8- 8474
Telephone Number 8 – 8950 Fax Number 8 - 7163 Beeper Numbers: 0847: S6U, S6D, FTN, L&D, MBU 8476: S5U, S5D, S5A, S5B, P4G Clinical Specialist Beeper: 2411 Updated 8/2000
University of Maryland Medical System Pediatric Antimicrobial ORAL Dosing Guidelines ( > 2 kg and > 7 days old) DRUG
ORAL DOSE
FREQUENCY
MAX/Dose
Amoxicillin
25 - 90 mg/kg/24h
q 12 h
875 mg
Amoxicillin/ Clavulanic Acid (Augmentin)
25 – 90 mg/kg/24h
q 12 h
875 mg
Azithromycin
5- 12 mg/kg/24h
q 24 h
500 mg
Cefpodoxime
10 mg/kg/24h
q 12 h
400 mg
Cephalexin
25 – 100 mg/kg/24h
q6h
1 gm
Ciprofloxacin
20 – 30 mg/kg/24h
q 12 h
750 mg
Clarithromycin
15 mg/kg/24h
q 12 h
500 mg
Clindamycin
10 – 30 mg/kg/day
q6h–8h
450 mg
Doxycycline
2 – 4 mg/kg/24h
q 12 h
100 mg
Erythromycin
30 – 50 mg/kg/24h (as ethylsuccinate)
q6h
800 mg
Erythromycin/ Sulfisoxazole (Pediazole)
40 – 50 mg/kg/24h q6h (as erythromycin component)
500mg
Fluconazole
3 – 12 mg/kg/24h
q 24 h
800mg
Penicillin VK
25 – 50 mg/kg/24h
q6h
500mg
TMP/SMX (Bactrim, Septra)
6 – 10 mg/kg/24h (as TMP component)
q 12 h
160 mg Updated 9/2000
Related Documents
Pediatric Antimicrobial Dosing
November 2019 8
Pediatric Dosing Article
July 2020 1
Antimicrobial Renal Dosing
November 2019 6
Pediatric Dosing P2
July 2020 1
Pediatric Dosing P3-4a
July 2020 5