Pathophysiology-mi.pptx

PATHOPHYSIOLOGY

Change in the condition of plaque in the coronary artery Activation of platelets Platelet Aggregation, Adhesion, & Buildup of Platelet Mass

Thrombosis

Release of Thromboplastin

Platelet release Thromboxane A2, Serotonin, Platelet Factors 3 and 4

ATHEROSCLEROSIS Rest Pain

Nausea and/or Vomiting

Claudication

Sweating

Fainting

Cool Extremities

Coagulation and Vasospasm

Enlargement of Thrombus

Occlusive Thrombus

Ischemia of Tissue in Region Supplied by Artery

Coronary Blood Supply Less than Demand

PALPITATIONS

MYOCARDIAL CELL DEATH (NECROSIS)

Decrease Oxygen Increase Carbon Dioxide Levels

Decrease Blood pH

DEEP & LABORED BREATHING

WEAKNESS / FATIGUE

INCREASE IN HEART RATE

Increase Basal Metabolic Rate

DIAPHORESIS

Stimulation of Sympathetic NS

Increase Epinephrine and Norepinephrine Production

Increase Oxygen Need

Decrease Blood Supply to GI Tract

Increase Afterload

Vasoconstriction NAUSEA / VOMITTING HYPERTENSION

ARRYTHMIAS

MYOCARDIAL CELL DEATH (NECROSIS) Decreased Contractility Decrease Ventricular Function

Increase Preload

Altered Repolarization of the Myocardium

Release of Lysosomal Enzymes

Anaerobic Glycolysis

Myocardial Irritability

Lactic Acid Production

Decrease Carbon Dioxide Decrease Blood Flow to Brain

LOSS OF CONSCIOUSNESS

ANGINA

DYSRHYTHMIA