Pathophys
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day 1
2009-06-22
Negative feedback system •
body temp going up to kill infection once the right temp is received the temp will maintain or go down
Stress •
Hans Selye ○ Used rats The rats had the same reaction to the stressors He coined GAS
Alarm stage •
Fright, Fight or Flight ○ Chemical
Stage of Resistance (Adaption) •
Are you going to do something about this
•
Hormones (Fright or Flight)
Stage of Exhaustion •
When body cannot cope and cannot get back to homeostasis
•
Where bad things can happen (disease, etc.)
Psychoneuroimmuology
•
Looking at how all the systems are connected
Much research
What have we found out? ○ How the body responds to stress Look to diagram
Stressor •
CNS activated and sends message to hypothalamus
•
Can also send a message to SNS
•
Hypothalamus sends message to ○ SNS, Anterior Pituitary and Posterior Pituitary
•
Sympathetic Nervous System ○ Norepinephrine Increase BP Increase Pupil dilation Increase gastric secreation
Etc
Other Hormones •
Endorphins ○ Natural opiates ○ Can be released in pleasure (exercise) ○ Can be felt during overwhelming pain (coping)
•
Growth Hormones ○ Released from anterior pituitary ○ Carbohydrate metabolism ○ Good when Under surgery and During exercise ○ Can cause a problem with chronic stress Will not develop properly
•
Prolactin ○ Breast milk (lactation and breast development) ○ Ante-pituitary ○ Adaptive response (when pregnant and need to prepare body to feed baby)
•
Oxytocin (childbirth) ○ Both men and women during orgasm
○ Also during stress like childbirth ○ Increase bonding with child (social attachment) •
Sex-steroids ○ Testosterone Chronic stress decrease in testosterone Veterans get shots of Testosterone
•
Unintentional and intentional injuries
Genes – cells the code for specific traits •
Locusts
Mutations – What happens when our DNA goes wrong •
Base pair substitutions – A-C and T-G ○ At some site along the chromosome instead of T-G it is A-C
2009-06-22
Negative feedback system •
body temp going up to kill infection once the right temp is received the temp will maintain or go down
Stress •
Hans Selye ○ Used rats The rats had the same reaction to the stressors He coined GAS
Alarm stage •
Fright, Fight or Flight ○ Chemical
Stage of Resistance (Adaption) •
Are you going to do something about this
•
Hormones (Fright or Flight)
Stage of Exhaustion •
When body cannot cope and cannot get back to homeostasis
•
Where bad things can happen (disease, etc.)
Psychoneuroimmuology
•
Looking at how all the systems are connected
Much research
What have we found out? ○ How the body responds to stress Look to diagram
Stressor •
CNS activated and sends message to hypothalamus
•
Can also send a message to SNS
•
Hypothalamus sends message to ○ SNS, Anterior Pituitary and Posterior Pituitary
•
Sympathetic Nervous System ○ Norepinephrine Increase BP Increase Pupil dilation Increase gastric secreation
Etc
Other Hormones •
Endorphins ○ Natural opiates ○ Can be released in pleasure (exercise) ○ Can be felt during overwhelming pain (coping)
•
Growth Hormones ○ Released from anterior pituitary ○ Carbohydrate metabolism ○ Good when Under surgery and During exercise ○ Can cause a problem with chronic stress Will not develop properly
•
Prolactin ○ Breast milk (lactation and breast development) ○ Ante-pituitary ○ Adaptive response (when pregnant and need to prepare body to feed baby)
•
Oxytocin (childbirth) ○ Both men and women during orgasm
○ Also during stress like childbirth ○ Increase bonding with child (social attachment) •
Sex-steroids ○ Testosterone Chronic stress decrease in testosterone Veterans get shots of Testosterone
•
Unintentional and intentional injuries
Genes – cells the code for specific traits •
Locusts
Mutations – What happens when our DNA goes wrong •
Base pair substitutions – A-C and T-G ○ At some site along the chromosome instead of T-G it is A-C
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