Pathophy Dengue Med Ward

F. PATHOPHYSIOLOGY RISK FACTORS: Demographic location All ages Both genders

4 VIRAL FAMILIES • Arenaviruses • Filoviruses • Bunyavrusues • Flaviviruses

RNA viruses that are carried by a female mosquito of two species of genus Aedes.

Bite from an Aedes mosquito Virus enters the body

Phagocytosis of virus by macrophage

Activation of immune system; cell mediated immunity, neutrophils, macrophages/monocytes Release of cell mediator cause attraction for nuetrophils,mono cytes, basophils, erythrocytes

Replication of vRNA genome producing new viruses Virus infected host cell infect neighboring host cells symptoms such as fever, headaches, and fatigue are the result of the huge amounts of pro inflammatory cytokines and chemokines (such as interferon or tumor necrosis factor) produced from dengue-infected cells

Initiate destruct ion of platelets

Causing systemic body reaction Increase potential for hemorrhage

Going to site of invasion to phagocyte

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sudden onset of fever (lasting three to seven days)

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intense headache (especially behind the eyes)

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muscle and joint pain (ankles, knees and elbows)

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unpleasant metallic taste in mouth, loss of appetite, vomiting, diarrhoea, abdominal pain

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flushed skin on face and neck, fine skin rashes as fever subsides

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rashes on arms and legs,

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minor bleeding (nose or gums)

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extreme fatigue

LEGEND: BLUE INK- not experienced by patient BLACK INK- experienced by patient