Patho 3_2 Neoplasm Pictures

In this picture, all the cells look primitive, enlarged with prominent nucleoli all the way to the top, and there are some mitosis on the top instead of the basal layer. This is an example of carcinoma in situ.

in this picture you can see the transitional epithelium of the bladder with a papillary transitional cell carcinoma and it’s low grade because you just see multiple layers but the nuclei are not that pleomorphic Low grade urothelial carcinoma

High grade urothelial carcinoma

Anaplastic carcinoma

Anaplasia + abnormal mitoses

In this picture you can see a high degree carcinoma and you can immediately notice the differences in pleomorphism of nuclei and their large size with dense dark chromatin and their irregular shapes and if you look carefully you can see more mitosis. This is an anaplastic carcinoma in which there are many layers of cells which are not differentiating to any other types of cells. Abnormal mitosis is another feature of anaplastic carcinoma in which there are mitotic cells with many poles - multipolar There are also tumor giant cells.

Adenoma - Thyroid In this picture you can see an adenoma of thyroid gland which is well defined and well circumscribed and it’s different from the normal tissue.

Adrenal adenoma in this picture you can see a homogenous adenoma of the adrenal gland. The homogenous surface is also useful in determining that this is a benign tumor because in malignant tumor you see other changes such as necrosis and hemorrhage.

Adenoma - Adrenal

Dysplastic squamous epithelium

In this picture you can see the cervical epithelium with a sharp line between the normal epithelium and the neoplasm. It’s carcinoma in situ because it has not broken the basement membrane. It’s malignant but has not invaded yet. If you scrip the normal epithelium the corneal layer with flat cells and picnotic nuclei will come out while in the case of neoplasm, you’ll get cells with very large nuclei, prominent nucleoli and may be mitosis, and that tells you that this is malignant.

Uterine cervix – squamous cell carcinoma

This is what you expected to see. The lesion is ulcerating and it’s growing outwards.

Infiltrating squamous cell carcinoma

This is what you see under the microscope. You can recognize that the growth is going deeper to the tissue so this is a carcinoma which is invading the surrounding tissue and is accompanied with inflammatory infiltrate.

Squamous cell carcinoma – Cheek

Squamous cell carcinoma doesn’t only affect the uterus, it can also affect the skin as you can see in this picture. There’s ulceration of skin in this type of carcinoma

Squamous cell carcinoma - Skin You can see that the tumor is invading the surrounding tissue