Pa Tho Physiology

Pathophysiology Etiology > Serotype Dengue Type 1-4 > Aedes aegypti

Predisposing Factors > Poor Environmental Sanitation > Poor Environmental Space > Immunocompromise

> Poor Garbage disposal > Poor Drainage system

Aedes aegypti (dengue virus carrier): 8-12 days of viral replication on mosquitos’ salivary glands ↓ Bite from mosquito ↓ Allowing dengue virus to be inoculated towards the circulation (Incubation Period: 3-14 days) ↓ Recognition of non-neutralizing Ab to the dengue virus ↓ Inability to neutralize non-inhibit virus replication ↓ Ab-Dengue virus bind ↓ Forming Ag-Ab complex ↓ Binding of Ag-Ab complex to the macrophage receptor site ↓ Internalize immune system ↓ Allowing virus to replicate and becomes more virulent ↓ Entry to the bone marrow ↓ Cellular direct destruction of red bone marrow precursor cells Release of vasoactive ↓ mediator Leukopenia, Bone pain, Thrombocytopenia Increase vascular permeability in plasma

Hypovolemic shock

Capillary Fragility Plasma leakage Thrombocytopeni a

Bleeding tendencies

Circulatory collapse

Activate arachidonic acid pathway

Death

Anaerobic metabolism

Heat dissipating mechanism

Muscle pain Weakness Muscle fatigue

Epistaxis

Gum bleeding Or Gingival bleeding

Initiates Hypothalamus Systemic response occurs

Lactic acid formation and metabolites

Petichiae

Tearing occurs during mechanical processes

Olfactory epithelial cell disruption

Release od Prostaglandin E2 (PGE2)

Poor skin turgor capillary refill Inadequate blood Low tissue perfusion supply to the muscle tissues Hg: 10.1

Inability to maintain the stability of platelet plug of smaller vessels and capillaries each surfaces Easily bruise

Release of endogenous pyrogens (Interleukin 1 and 4)

BP: 90/60 CR: 4sec Slow venous filling

Diaphoresis Irreversible brain Chilling damage if left unthreatened

UGI visceral tissue disruption

Abdominal pain d/t tissue exposure to enzymes

Fever

Nausea and vomiting Sore throat Anorexia Tasteless sensation Melena Hematemesis,

Note: All clinical manifestations are delivered as to mechanisms and are combined patient and disease based pattern.