Oxycodone Hydro Chloride

  • November 2019
  • PDF

This document was uploaded by user and they confirmed that they have the permission to share it. If you are author or own the copyright of this book, please report to us by using this DMCA report form. Report DMCA


Overview

Download & View Oxycodone Hydro Chloride as PDF for free.

More details

  • Words: 788
  • Pages: 3
oxycodone hydrochloride (ox i koe' done) Endocodone, M-oxy, OxyContin, Oxydose, OxyFAST, OxyIR, Percolone, Roxicodone, Roxicodone Intensol, Supeudol (CAN) Pregnancy Category C Controlled Substance C-II Drug class

Opioid agonist analgesic Therapeutic actions

Acts as agonist at specific opioid receptors in the CNS to produce analgesia, euphoria, sedation; the receptors mediating these effects are thought to be the same as those mediating the effects of endogenous opioids (enkephalins, endorphins). Indications

• •

Relief of moderate to moderately severe pain CR tablets: Management of moderate to severe pain when a continuous, aroundthe-clock analgesic is needed for an extended period of time

Contraindications and cautions





Contraindicated with hypersensitivity to opioids, diarrhea caused by poisoning (before toxins are eliminated); pregnancy (readily crosses placenta; neonatal withdrawal); labor or delivery (opioids given to the mother can cause respiratory depression in neonate; premature infants are at special risk; may prolong labor); bronchial asthma, COPD, cor pulmonale, respiratory depression, anoxia, kyphoscoliosis, acute alcoholism, increased intracranial pressure, lactation. Use cautiously with acute abdominal conditions, CV disease, supraventricular tachycardias, myxedema, seizure disorders, delirium tremens, cerebral arteriosclerosis, ulcerative colitis, fever, Addison's disease, prostatic hypertrophy, urethral stricture, recent GI or GU surgery, toxic psychosis, renal or hepatic dysfunction.

Available forms

Tablets—5 mg; IR capsules—5 mg; IR tablets—15, 30 mg; CR tablets—10, 20, 40, 80, 160 mg; oral solution—5 mg/5 mL; solution concentrate—20 mg/ml Dosages

Individualize dosage. ADULTS

10–30 mg PO q 4 hr. OxyIR, OxyFAST, 5 mg q 3–6 hr. Controlled-release (OxyContin), 10–20 mg PO q 12 hr. • Breakthrough pain: Immediate-release (OxyIR): 5 mg PO q 4 hr. PEDIATRIC PATIENTS

Controlled-release is not recommended for pediatric patients. Regular and IR dosage should be individualized based on patient's age and size.

GERIATRIC PATIENTS OR IMPAIRED ADULTS

Use caution. Respiratory depression may occur in the elderly, the very ill, those with respiratory problems. Pharmacokinetics Route Oral

Onset 15–30 min

Peak 1 hr

Duration 4–6 hr

Metabolism: Hepatic; T1/2: 2–3 hr Distribution: Crosses placenta; enters breast milk Excretion: Urine Adverse effects



• • • • • •

CNS: Light-headedness, dizziness, sedation, euphoria, dysphoria, delirium, insomnia, agitation, anxiety, fear, hallucinations, disorientation, drowsiness, lethargy, impaired mental and physical performance, coma, mood changes, weakness, headache, tremor, seizures, miosis, visual disturbances CV: Facial flushing, peripheral circulatory collapse, tachycardia, bradycardia, arrhythmia, palpitations, chest wall rigidity, hypertension, hypotension, orthostatic hypotension, syncope, circulatory depression, shock, cardiac arrest Dermatologic: Pruritus, urticaria, edema, hemorrhagic urticaria (rare) GI: Nausea, vomiting, sweating (more common in ambulatory patients and those without severe pain), dry mouth, anorexia, constipation, biliary tract spasm; increased colonic motility in patients with chronic ulcerative colitis GU: Ureteral spasm, spasm of vesical sphincters, urinary retention or hesitancy, oliguria, antidiuretic effect, reduced libido or potency Respiratory: Suppression of cough reflex, respiratory depression, apnea, respiratory arrest, laryngospasm, bronchospasm Other: Physical tolerance and dependence, psychological dependence

Interactions

Drug-drug • Increased likelihood of respiratory depression, hypotension, profound sedation or coma in patients receiving barbiturate general anesthetics, protease inhibitors Drug-lab test • Elevated biliary tract pressure may cause increases in plasma amylase, lipase; determinations for 24 hr after administration Nursing considerations Assessment



History: Hypersensitivity to opioids, diarrhea caused by poisoning, pregnancy, labor or delivery, bronchial asthma, COPD, cor pulmonale, respiratory depression, kyphoscoliosis, acute alcoholism, increased intracranial pressure, acute abdominal conditions, CV disease, myxedema, seizure disorders, cerebral arteriosclerosis, ulcerative colitis, fever, Addison's disease, prostatic hypertrophy, urethral



stricture, recent GI or GU surgery, toxic psychosis, renal or hepatic dysfunction, lactation Physical: T; skin color, texture, lesions; orientation, reflexes, bilateral grip strength, affect, pupil size; P, auscultation, BP, orthostatic BP, perfusion; R, adventitious sounds; bowel sounds, normal output; frequency and pattern of voiding, normal output; ECG; EEG; thyroid, liver, kidney function tests

Interventions

• • • • • •

Administer to nursing women 4–6 hr before the next feeding to minimize amount in milk. Do not crush or allow patient to chew controlled-release preparations. Administer immediate-release preparations to cover breakthrough pain. OxyFAST and Roxicodone Intensol are highly concentrated preparations. Use extreme care with these preparations. Keep opioid antagonist and facilities for assisted or controlled respiration readily available during parenteral administration. Reassure patient about addiction liability; most patients who receive opiates for medical reasons do not develop dependence syndromes.

Teaching points

• • •



Take drug exactly as prescribed. Do not crush or chew controlled-release preparations. Do not take any leftover medication for other disorders, and do not let anyone else take the prescription. These side effects may occur: Nausea, loss of appetite (take with food, lie quietly, eat frequent small meals); constipation (use a laxative); dizziness, sedation, drowsiness, impaired visual acuity (avoid driving, performing other tasks that require alertness, visual acuity). Report severe nausea, vomiting, constipation, shortness of breath, or difficulty breathing.

Adverse effects in Italic are most common; those in Bold are life-threatening.

Related Documents

Oxycodone Hydro Chloride
November 2019 11
Cetirizine Hydro Chloride
November 2019 18
Zine Hydro Chloride
November 2019 17
Benazepril Hydro Chloride
November 2019 20
Atomoxetine Hydro Chloride
November 2019 21
Labetalol Hydro Chloride
November 2019 22