Outline-metabolism And Metabolomics

Outline Metabolic Homeostasis, Metabolic Disorders and Metabolomics

Part 1. Metabolic Pathways and Homeostasis 1) Overview of glucose and lipid metabolism 2) Cross-talks between organs in energy homeostasis and metabolism a) Lessons from tissue-selective gene-targeting b) Central control of energy balance 3) Key regulatory signaling pathways a) Leptin b) Insulin c) Adiponectin

Part 2. Metabolic Diseases 1) 2)

Overview: Obesity, type 2 diabetes and metabolic syndrome The molecular basis of pathophysiology a) Leptin resistance b) Insulin resistance c)

Impaired pancreatic β-cell function

The molecular links between obesity and diabetes 3) Drugs and New Targets d)

Part 3. Metabolomics and Applications 1) Introduction to Metabolomics a) Major features and technologies b) Metabolic profiling 2) Applications in metabolic research a) Function of metabolic enzymes b) Diagnostic and prognostic analysis c) Metabolic signaling

Discussion Paper Decheng Ren, Minghua Li, Chaojun Duan and Liangyou Rui. (2005) Identification of SH2-B as a key regulator of leptin sensitivity, energy balance, and body weight in

mice. Cell Metab. 2:95-104.