Osmotic Diuretics.docx

Osmotic Diuretics (e.g. Mannitol)    

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Acts mostly on Proximal Convoluted Tubule Unlike other diuretics, does not influence renin synthesis. Thus, it does not promote diuresis and natriuresis Oral: has a laxative effect and not absorbed IV: filtered in glomerulus but not reabsorbed in the renal tubules o Effects:  increased osmotic pressure  Excretion of isosmotic equivalent of water Increases blood flow by 30% Does not penetrate the eyes and brain, thus in an osmotic way, reduces intraocular and intracranial pressures o Treatment for  Brain edema  Acute and chronic renal failures  Glaucoma  Drug intoxication