One System - Multiple Tests General_sfn_2007

Animal Behavior Analysis Solutions

One system – Multiple tests Saving Time, Money and Animals

The LABORAS system

∇ LABORAS automatically recognises behaviors based on vibration analysis ∇ One LABORAS system o distinguishes more than 16 different rat and mouse behaviours o provides high resolution position tracking o can be integrated with telemetry measurements and data processing (heart rate, blood pressure, temperature) ∇ On a single LABORAS system the researcher can perform many different animals tests ∇ Proven system that saves up to 75% of your experiment leadtime and decreases 90% of your day-to-day workload ∇ Improves animal behaviour scoring of fast movements like scratching, WDS and head shakes ∇ Operates independent of light; high quality scoring in dark when the animals are most active ∇ 8 platform configuration: High throughput proven up to 1200 test sessions per month! ∇ Storage of 1 MB/hrs/animal raw data enables re-use of existing experiments with new behaviour detection modules: avoid repeating experiments. ∇ Examples: (Primary) Observation Test, Motor Activity Test, Open Field Test, Eating Test, Drinking Test, (Anti-)Convulsive Test

Metris BV

Kruisweg 801a • 2132 NG Hoofddorp • The Netherlands • Tel. +31 (0)23 562 3400

• www.metris.nl • [email protected]

Animal Behavior Analysis Solutions

Automatic scoring of behavior Tracking

Normal behaviours

High resolution XY position Velocity (avg, max, Lmax) Distance travelled Position Distribution Circling & Turning (CW & CCW) Estimation of energy use*

Locomotion Immobility Rearing Grooming Eating Drinking Climbing

Special behaviors Scratching Paw Licking Purposeless Chewing Circling / Turning Seizures (tonic-clonic) Seizures (barrel rolls) Seizures (P5 and P4) Wet Dog Shakes Head Shakes Head Twitches

from Treatment to Dose Response Curve

Leads to R e s e a rc h B io lo g y

B a s ic R e s e a rc h

T a rg e t V a li d a ti o n

T a r g e t ID

D e v e lo p m e n t

C h e m is t r y

S c r e e n in g

O p ti m iz a t io n

P r e - c lin ic a l D e v elop m e n t

P hase I

P h a s e II

P h a s e II I

R e g u la t o r y

D e c r e a s e R & D le a d tim e R e se a rc h B io lo g y

B a s ic R e s e a rc h

T a r g e t ID

T a rg e t V a l i d a tio n

O p t im iz a t io n

In c r e a s e p a te n t p r o fit

D e v e lo p m e n t

C h e m is t r y

S c r e e n in g

P r o d u c t io n

C lin ic a l D e v e lo p m e n t

C li n ic a l D e v e lo p m e n t

P r e - c lin ic a l D e v e lo p m e n t

P hase I

P h a s e II

P h a s e II I

R e g u la t o r y

Saving time and workload & improving R&D Profit from earlier introduction of your new drug For commercial information please contact [email protected].

Metris BV

Kruisweg 801a • 2132 NG Hoofddorp • The Netherlands • Tel. +31 (0)23 562 3400

• www.metris.nl • [email protected]