Molahidatidosa.docx

Hydatiform mole is a benign neoplasm of the chorion in which the chorionic villi degenerate and become transparent vesicles containing clear, viscid fluid. Hydatiform mole is classified as complete or partial, distinguished by differences in clinical presentation, pathology, genetics, and epidemiology ( Garner et al., 2007). The complete mole contains no fetal tissue and develops from an “empty egg,” which is fertilized by a normal sperm( the paternal chromosomes replicate, resulting in 46 all-paternal chromosomes). The embryo is not viable and dies. No circulation is established, and no embryonic tissue is found. The complete mole is associated with the development of chriocarcinoma. The partial mole has a triploid karyotype (69 chromosomes) , because two sperm have provided a double contribution by fertilizing the ovum. The exact cause of molar pregnancy is unknown, but researchers are looking into a genetic basis. Studies have revealed some remarkable features about molar pregnancies, including:  Ability to invade into the wall of the uterus  Tendency to recur in subsequent pregnancies  Possible development into choriocarcinoma, a virulent cancer with metastatis to other organ 