Micro - 4th Asessment - Oncogenic Viruses - 5 Feb 2007

Oncogenic Viral Infections 4th Year Medical Students, February, 2007

Virus-tumor association 

Normal and tumor cell

Transformed cell

Tumor associated RNA viruses Retroviruses: 

HTLV-I – Adult T-cell leuk/ly HTLV-II- Hairy cell leukemia

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Endogenous retrov.?? Hepatitis C virus: – Primary liver

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DNA viruses 

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Papilloma, Polyoma, Vacuolating (PAPOVA) Small DNA “tumor” viruses

Papillomaviruses >70 human PV types Growing only in special cell cultures Specific proteins DNA is in stratum germinativum Virion in keratinocytes

Papillomaviruses

Papillomaviruses 

Clinical manifestations: 1. Cutaneous warts – hyperkeratosis (“benign tumors”)

Verruca plana

V. plantaris

V.vulgaris

Papillomaviruses 

Clinical manifestations ctd. Epidermodysplasia verruciformis

Papillomavirues 

Genital warts Condyloma acuminata

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Laryngeal papilloma Oral leukoplakia

Papillomaviruses 

Cervical cancer (16,18) Cervical Intraepith. Neoplasia Pap smear: staging, progression

Papillomaviruses 

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Cofactors: Immune suppression UV irradiation Genetic background Diagnosis: histology, DNA hybridization, PCR Treatment: caustic agents (e.g. podophylline, duofilm), cryotherapy, laser, surgical,

Polyomaviruses 

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JC virus: Progressive multifocal leukoencephalopathy (PML) , Tumor? BK virus: In transplant patients: hemorrhagic cystitis ureteric stenosis, BKV nephropathy (BKVN) Tumor?

Polyomaviruses 

BK virus antigen cells

Clue (decoy)

Polyomaviruses 

Genomic detection of BK and JC viruses

Polyomaviruses

Herpesviruses EBV – Burkitt’s L., B-cell lymphoma,

NPC

Herpes- and hepatitis B virus HHV-8 – Kaposi sarcoma

HBV – Primary liver cancer

M. Kaposi, Dermatologist, 1817-1902