FJRC.MS.MetabolicAlterations
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MEtaBol iC aLteRaTiONs
Francis Jordan Ramos Cusi, RN FJRC.MS.MetabolicAlterations
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EN DO CRI NE SYSTEM Glands Hormones Receptors
Amines Polypeptides Steroids
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GLAN DS OF TH E EN DOC RINE SY STEM
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HYP OTH AL AM US Lies dorsal to the pituitary gland Nervous-Endo Regulator ata ako! : A-PTH Hypophyseal stalk TRH, GnRH, GHRH, CRH, Dopamine FJRC.MS.MetabolicAlterations
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PI NEA L GLAN D Cone-shaped Back of the third ventricle of the brain Mystery-mystery! Melatonin
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PITUITAR Y GLAND Under (below) hypothamalus Bi-functional lobes + 1 Anterior and Posterior + pars intermedia AKA: Hypophysis Small (1 gram) FJRC.MS.MetabolicAlterations
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ANTE RIOR PITUITARY ADENOhypophysis Hormones: Proteins; 2nd-messanger system; regulated by hormonal stimuli T – Thyroid stimulating hormone (TSH; Thyrotropin) F – Follicle stimulating hormone L – Luteinizing hormone A – Adrenocorticotropic hormone P - Prolactin S – Somatotropin (Growth Hormone) FJRC.MS.MetabolicAlterations
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POS TERIO R PI TUI TAR Y
Pede na rin Hamak na imbakan OXYTOCIN ANTIDIURETIC HORMONE (Vasopressin) FJRC.MS.MetabolicAlterations
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T H YROI D GL AND H urray! Hurray! Le – H – eg H – either side H – istHmus connected TriiodotHyronine (T3) – more potent THyroxine – less Calcito-H-nin
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PARA THY ROID GLA NDS
Tagong kabit Kaya hanggang 8, 4 ang legal (daw) PARATHORMONE: most popular regulator of calcium ions FJRC.MS.MetabolicAlterations
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TH YMUS GLAND
Upper thorax Immuno-endo Thymosin : T-lymphocytes maturation FJRC.MS.MetabolicAlterations
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ENDOC RI NE PANC REAS
Pancreatic islets : New-NSO reg GA-BIDS FJRC.MS.MetabolicAlterations
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ADRE NAL GL AND S ADRENALINE: R – esembles bean (each) U – ri’y pituitary (glandular ; neural) S – ituated top of the kidney H – ati: Cortex(co), Medulla(mines) FJRC.MS.MetabolicAlterations
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GO NA DS OVARIES: mainly estradiol TESTES: testosterone FJRC.MS.MetabolicAlterations
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These are blood examinations for the levels of individual hormones Measurements can also be done after stimulation and suppression of the secretions- Stimulation and Suppression tests FJRC.MS.MetabolicAlterations
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Usually done to diagnose hypo/hyperthyroidism If T3 is elevated, T4 is elevated and TSH is depressed Primary HYPERthyroidism If T3 is depressed,T4 is depressed and TSH is elevated Primary HYPOthyoidism FJRC.MS.MetabolicAlterations
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This is a thyroid function test to measure the absorption of the injected iodine isotope by the thyroid tissue Increased uptake may indicate HYPER functioning gland Decreased uptake my FJRC.MS.MetabolicAlterations
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Performed to identify nodules or growth in the thyroid gland RAI is used Pretest- Check for pregnancy, Thyroid medication may be withheld temporarily, advise NPO Post-test- Ensure proper FJRC.MS.MetabolicAlterations
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Aids in the diagnosis of Diabetes Pre-test: NPO for 8 hours Normal FBS- 80-109 mg/dL DM- 126 mg/dL and above FJRC.MS.MetabolicAlterations
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Aids in the diagnosis of DM Pre-test: Provide highcarbohydrate foods x 3 days, instruct to avoid caffeine, alcohol and smoking, NPO 10 hours prior to test Post-test: avoid strenuous activity for 8 hours Normal OGTT- 1 and 2 hours FJRC.MS.MetabolicAlterations 30 post-prandial- glucose is less
Blood glucose bound to RBC hemoglobin Reflects how well blood glucose is controlled for the past 3 months FASTING is NOT required! FJRC.MS.MetabolicAlterations
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Normal levelexpressed as percentage of total hemoglobin N- 4-7% Good control- 7.5%or less Fair control- 7.5 % to 8.9% Poor control- 9% and above FJRC.MS.MetabolicAlterations 32
DISORDERS OF THE ENDOCRINE GLAND Disorders are generally grouped into: HYPER- when the gland secretes excessive hormones HYPO- when the gland does not secrete enough hormones FJRC.MS.MetabolicAlterations
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Hyper and Hypo can be classified as PRIMARY when the Gland itself is the problem or SECONDARY when the pituitary or the hypothalamus is causing the problem
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THY RO ID DIS OR DE RS
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HYP ERTI RE DDYTI ES
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A hypothyroid state characterized by decreased secretions of T3 and T4 CAUSES: Hypofunctioning tumor, IDG, Pituitary tumor, Ablation therapy, Surgical removal of thyroid FJRC.MS.MetabolicAlterations
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Decreased T3 and T4 decreased basal metabolism
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1. Lethargy and fatigue 2. Weakness and paresthesia 3. COLD intolerance 4. Weight gain 5. Bradycardia, constipation FJRC.MS.MetabolicAlterations
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6. Dry hair and skin, loss of body hair 7. Generalized puffiness and edema around the eyes and face8. Forgetfulness and memory loss 9. Slowness of movement 10. Menstrual irregularities and cardiac irregularities FJRC.MS.MetabolicAlterations
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1. Monitor VS especially HR 2. Administer hormone replacement: usually Levothyroxine( Synthroid)should be taken on an empty stomach 3. Instruct patient to eat LOW calorie, LOW FJRC.MS.MetabolicAlterations
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4. Manage constipation appropriately 5. Provide a WARM environment 6. Avoid sedatives and narcotics because of increased sensitivity to these medications 7. Instruct patient to report chest pain promptly FJRC.MS.MetabolicAlterations
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Called GRAVE’S DISEASE A hyperthyroid state characterized by increased circulating T3 and T4 CAUSES: Auto-immune disorder, toxic FJRC.MS.MetabolicAlterations goiter and tumor
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Increased hormone activity increased Basal Metabolism
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1. Weight loss 2. HEAT intolerance 3. Hypertension 4. Tachycardia and palpitations 5. Exopthalmos 6. Diarrhea FJRC.MS.MetabolicAlterations
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7. Warm skin 8. Diaphoresis 9. Smooth and soft skin Oligomenorrhea to amenorrhea 10. Fine tremors and nervousness 11. Irritability, mood swings, personality changes and agitation FJRC.MS.MetabolicAlterations
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1. Provide adequate rest periods in a quiet room 2. Administer anti-thyroid medications that block hormone synthesisMethimazole and PTU 3. Provide a HIGH-calorie diet, HIGH protein FJRC.MS.MetabolicAlterations
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4. Manage diarrhea 5. Provide a cool and quiet environment 6. Avoid giving stimulants 7. Provide eye care Hypoallergenic tape for eyelid closure 8. Administer PROPRANOLOL for tachycardia 9. Administer IODIONE preparation- Lugol’s solution and SSKI to inhibit the release of T3 and T4 FJRC.MS.MetabolicAlterations 50 FJRC.MS.MetabolicAlterations
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10. Prepare clients for Radioactive iodine therapy 11. Prepare patient for thyroidectomy 12. Manage thyroid storm appropriately FJRC.MS.MetabolicAlterations
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An acute LIFEthreatening condition characterized by excessive thyroid hormone
CAUSE: Manipulation of the thyroid during surgery causing the release of excessive hormones in the FJRC.MS.MetabolicAlterations
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1. HIGH fever 2. Tachycardia and Tachypnea 3. Systolic HYPERtension 4. Delirium and coma 5. Severe vomiting and diarrhea FJRC.MS.MetabolicAlterations
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1. Maintain PATENT airway and adequate ventilation 2. Administer anti-thyroid medications such as Lugol’s solution, Propranolol, and Glucocorticoids 3. Monitor VS FJRC.MS.MetabolicAlterations
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4. Monitor Cardiac rhythms 5. Administer PARACETAMOL ( not Aspirin) for FEVER 6. Manage Seizures as required. FJRC.MS.MetabolicAlterations
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Removal of the thyroid gland
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1. Obtain VS and weight 2. Assess for Electrolyte levels, glucose levels and T3/T4 levels 3. Provide pre-operative teaching like coughing and deep breathing, early ambulation and support of the neck when moving 4. Administer prescribed FJRC.MS.MetabolicAlterations 57 medications
1. Position patient: SemiFowler’s, neck on neutral position 2. Monitor for respiratory distress- apparatus at bedsidetracheostomy set, O2 tank and suction machine! 3. Check for edema and FJRC.MS.MetabolicAlterations 58 bleeding by noting the
4. LIMIT client talking 5. Assess for HOARSENESS Expected to be present only initially, limit excess vocalization If persistent, may indicate damage to laryngeal nerve! 6. Monitor for Laryngeal Nerve damage – Respiratory distress, Dysphonia, voice changes, Dysphagia and restlessness FJRC.MS.MetabolicAlterations
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7. Monitor for signs of HYPOCALCEMIA and tetany due to trauma of the parathyroid 8. Prepare Calcium gluconate 9. Monitor for thyroid storm FJRC.MS.MetabolicAlterations
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PAR ATHY ROI D DI SOR DERS
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Hypo-secretion of parathyroid hormone CAUSES: Tumor, removal of the gland during thyroid surgery FJRC.MS.MetabolicAlterations
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Decreased PTH deranged calcium metabolism
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1. Signs of HYPOCALCEMIA 2. Numbness and tingling sensation on the face 3. Muscle cramps 4. (+) Trosseau’s and (+) Chvostek’s signs 5. Bronchospasms, laryngospasms, and dysphagia FJRC.MS.MetabolicAlterations
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6. Cardiac dysrhythmias 7. Hypotension 8. Anxiety, irritability ands depression
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Monitor VS and signs of HYPOcalcemia Initiate seizure precautions and management Place a tracheostomy set. O2 tank and suction at the bedside Prepare CALCIUM gluconate Provide a HIGH-calcium and LOW phosphate diet FJRC.MS.MetabolicAlterations
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Advise client to eat Vitamin D rich foods Administer Phosphate binding drugs
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Hypersecretion of the gland CAUSE: Tumor
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Increase PTH increased CALCIUM levels in the body
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Fatigue and muscle weakness/pain Skeletal pain and tenderness Fractures Anorexia/N/V epigastric pain Constipation FJRC.MS.MetabolicAlterations
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Hypertension Cardiac Dysrhythmias Renal Stones
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Monitor VS, Cardiac rhythm, I and O Monitor for signs of renal stones, skeletal fractures. Strain all urine. Provide adequate fluids- force fluids AdministerFJRC.MS.MetabolicAlterations prescribed 73
Administer calcium chelators Administer CALCITONIN Prepare the patient for surgery FJRC.MS.MetabolicAlterations
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ADR EN OCO RT ICAL DI SO RDE RS
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Decreased secretion of adrenal cortex hormones, especially glucocorticoids and mineralocorticoids CAUSE: Tumor, idopathic FJRC.MS.MetabolicAlterations
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Decreased Glucocorticoids decreased resistance to stress
Decreased mineralocorticoids decreased retention of sodium and water Hypovolemia FJRC.MS.MetabolicAlterations
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Weight loss GI disturbances Muscle weakness, lethargy and fatigue Hyponatremia
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Hyperkalemia Hypoglycemia dehydration and hypovolemia Increased skin pigmentation FJRC.MS.MetabolicAlterations
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Monitor VS especially BP Monitor weight and I and O Monitor blood glucose level and K Administer hormonal agents as prescribed FJRC.MS.MetabolicAlterations
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Observe for ADDISONIAN crisis Educate the client regarding lifelong treatment, avoidance of strenuous activities, stress and seeking prompt consult during illness Provide a high-protein, high carbohydrate and increased sodium intake FJRC.MS.MetabolicAlterations
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A life-threatening disorders caused by acute severe adrenal insufficiency CAUSES: Severe stress, infection, trauma or surgery FJRC.MS.MetabolicAlterations
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Overwhelming stimuli mobilize body defense decreased stress hormones inadequate coping FJRC.MS.MetabolicAlterations
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Severe headache Severe pain Severe weakness Severe hypotension Signs of Shock FJRC.MS.MetabolicAlterations
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Administer IV glucocorticoids, usually hydrocortisone Monitor VS frequently Monitor I and O, neurological status, electrolyte imbalances and FJRC.MS.MetabolicAlterations
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Administer IVF Maintain bed rest Administer prescribed antibiotics
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A condition resulting from the hyper-secretion of glucocorticoids from the adrenal cortex CAUSES: Pituitary tumor, adrenal tumor, abuse of steroids FJRC.MS.MetabolicAlterations
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Increased Glucocorticoids exaggerated effects of the hormone
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Normal functions of Cortisol
1. Gluconeogenesis 2. Protein breakdown
3. Fat breakdown
Exaggerated functions HYPERGLYCEMIA OSTEOPOROSISS, delayed wound healing Purplish striae , Bleeding Muscle wasting THIN extremity, Truncal deposition
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4. Decreased WBC
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Functions of Mineralocorticoids
Exaggerated functions
1. Sodium Retention
Hypernatremia
2.Secondary water retention
HypervolemaHypertension
3. Potassium excretion
HYPOKALEMIA
Function of androgen: Hair growth
HIRSUTISM
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Generalized muscle weakness and wasting Truncal obesity Moon-face Buffalo hump Easy bruisability FJRC.MS.MetabolicAlterations
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Reddish-purplish striae on the abdomen and thighs Hirsutism and acne Hypertension Hyperglycemia Osteoporosis Amenorrhea FJRC.MS.MetabolicAlterations
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Serum cortisol level Serum glucose and electrolytes
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Monitor I and O , weight and VS Monitor laboratory valuesglucose, Na, K and Ca Provide meticulous skin care Administer prescribed medications like aminogluthetimide to inhibit adrenal hyperfunctioning FJRC.MS.MetabolicAlterations
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Prepare client for surgical management- pituitary surgery and adrenalectomy Protect patient from infection Improve body image Provide a LOW carbohydrate, LOW sodium and HIGH protein FJRC.MS.MetabolicAlterations
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ADR EN OMED ULLAR Y DI SO RDE R
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Increased secretion of epinephrine and norepinephrine by the adrenal medulla CAUSE: Tumor FJRC.MS.MetabolicAlterations
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Increased Adrenergic hormones exaggerated sympathetic effects FJRC.MS.MetabolicAlterations
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Hypertension Severe headache Palpitations Tachycardia Profuse sweating and Flushing Weight loss, tremors FJRC.MS.MetabolicAlterations Hyperglycemia and
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Monitor VS especially BP Monitor for HYPERTENSIVE crisis Avoid stimulation that can cause increased BP Administer Antihypertensive agents like alpha-adrenergic blockersFJRC.MS.MetabolicAlterations
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Prepare Phentolamine for hypertensive crisis Monitor blood glucose and urine glucose Promote adequate rest and sleep periods FJRC.MS.MetabolicAlterations
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Provide HIGH calorie foods and Vitamins/mineral supplements Prepare patient for possible surgery
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AN TER IOR PIT UIT ARY DI SO RDE RS
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Hyposecretion of the anterior pituitary gland CAUSES: Congenital, Post-partal necrosis, infection and tumor
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Depends on the major hormone/s depleted
Findings Retarded physical growth due to decreased GH dwarfism Low intellectual development Poor development of secondary sexual FJRC.MS.MetabolicAlterations
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Provide emotional support to the family Encourage client and family to express feelings Administer prescribed hormonal replacement therapy FJRC.MS.MetabolicAlterations
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The hyper-secretion of the gland ACROMEGALY CAUSES: tumor, congenital disorder FJRC.MS.MetabolicAlterations
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Depends on the hormone/s that is/are increased
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Increased growth Gigantism or Acromegaly Large and thick hands and feet Visual disturbances Hypertension, hyperglycemia Organomegaly FJRC.MS.MetabolicAlterations
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Provide emotional support to clients and family Provide frequent skin care Prepare patient for surgeryremoval of pituitary gland FJRC.MS.MetabolicAlterations
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Monitor VS, LOC and neurologic status Place patient on SemiFowler’s Monitor for Increased ICP, bleeding, CSF leakage Instruct patient to AVOID sneezing, coughing and nose-blowing FJRC.MS.MetabolicAlterations
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Monitor development of DImeasure I and O Administer prescribed medications- antibiotics, analgesics and steroids
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POS TER IOR PIT UIT ARY DI SO RDE RS
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A hypo-secretion of ADH CAUSES: Conditions that increase ICP, Surgical removal of post pit. tumor FJRC.MS.MetabolicAlterations
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Decreased ADH failure of tubular re-absorption of water increased urine volume
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Polyuria of more than 4 liters of urine/day Polydipsia Signs of Dehydration Muscle pain and weakness Postural hypotension and tachycardia FJRC.MS.MetabolicAlterations
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Urinary Specific gravity very low, 1.006 or less Serum Sodium levels high
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Monitor VS, neurologic status and cardiovascular status Monitor Intake and Output Monitor urine specific gravity FJRC.MS.MetabolicAlterations
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Provide adequate fluids Administer Chlorpropamide or Clofibrate as prescribed to increase the action of ADH if decreased Administer VASOPRESIN. Desmopressin or Lypressin are given intranasal. Pitressin is given IM FJRC.MS.MetabolicAlterations
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Hyper-secretion of ADH abnormally CAUSES: Tumor, paraneoplastic syndromes FJRC.MS.MetabolicAlterations
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Increased ADH water reabsorption water intoxication, hypervolemia
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Urine specific gravity is increased (concentrated) Hyponatremia CBC shows hemodilution FJRC.MS.MetabolicAlterations
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Signs of Hypervolemia Mental status changes Abnormal weight gain FJRC.MS.MetabolicAlterations
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Hypertension Anorexia, Nausea and Vomiting HYPOnatremia FJRC.MS.MetabolicAlterations
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Monitor VS and neurologic status Provide safe environment Restrict fluid intake (less than 500cc/day) FJRC.MS.MetabolicAlterations
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Monitor I and O and daily weight Administer Diuretics and IVF carefully Administer prescribed Demeclocycline to inhibit action of ADH in the kidney FJRC.MS.MetabolicAlterations
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END O-P AN CRE AS DI SO RDE R
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General information Diabetes mellitus represents a heterogeneous group of chronic disorders characterized by hyperglycemia. Hyperglycemia is due to total or partial insulin deficiency or insensitivity of the cells to insulin. Characterized by disorders in the metabolism of carbohydrates, fat and protein, as well as changes in the structure and function of blood vessels FJRC.MS.MetabolicAlterations 133
Most common endocrine problem; affects over 11 million people in the US Exact etiology unknown, causative factors may include Genetics, viruses, and/or autoimmune response in type I Genetics and obesity in type II
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Types Type I (insulindependent diabetes mellitus [IDDM]) cells in the islets of Langerhans in the pancreas resulting in little or no insulin production; requires insulin injections Usually occurs in children or in nonobese adults FJRC.MS.MetabolicAlterations
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Type II (non-insulin-dependent diabetes mellitus [NIDDM]) May result from a partial deficiency of insulin production and/or an insensitivity of the cells to insulin Usually occurs in obese adults over 40
Diabetes associated with other conditions or syndromes, e.g., pancreatic disease, Cushing’s syndrome, use of certain drugs (steroids, thiazide diuretics, oral contraceptives) FJRC.MS.MetabolicAlterations
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Lack of insulin causes hyperglycemia (insulin is necessary for the transport of glucose across the cell membrane). Hypergycemia leads to osmotic diuresis as large amounts of glucose pas through the kidney; results in polyuria and glycosuria Diuresis leads to cellular dehydration and fluid and electrolyte depletion causing polydipsia (excessive thirst). Polyphagia (hunger and increased appetite) results from cellular starvation137 FJRC.MS.MetabolicAlterations
The body turns to fats and protein for energy; but in the absence of glucose in the cell, fats cannot be completely metabolized and ketones (intermediate products of fat metabolism) are produced. This leads to ketonemia, ketonuria (contributes to osmotic diuresis), and metabolic acidosis (ketones are acid bodies) Ketones act as CNS depressants and can cause coma. Excess loss of fluids and electrolytes leads to hypovolemia, hypotension renal failure, and decreased blood flow to the brain resulting in coma and death unless treated. Acute complications of diabetes include diabetic ketoacidosis insulin reaction hyperglycemic insulin reaction FJRC.MS.MetabolicAlterations hyperglycemic 138
Type I: insulin, diet, exercise Type II: ideally managed by diet and exercise; may need oral hypoglycemic or occasionally insulin if diet and exercise are not effective in controlling hyperglycemia; insulin needed for acute stresses, e.g., surgery, infection FJRC.MS.MetabolicAlterations
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Diet Type I: consistency is imperative to avoid hypoglycemia Type II: weight loss is important since it decreases insulin resistance High fiber, low fat diet also recommended
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Drug therapy Insulin: used for Type I diabetes (also occasionally used in Type II diabetes) short acting: used in treating ketoacidosis; during surgery, infection, trauma; management of poorly controlled diabetes; to supplement longer-acting insulin’s intermediate; used for maintenance therapy Long acting: used for maintenance therapy in clients who experience hyperglycemia during the night with intermediate-acting insulin FJRC.MS.MetabolicAlterations
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Various preparations of short-, intermediate-, and long acting insulins are available Insulin preparations can consist of mixture of beef and pork insulin, pure beef, pure pork, or human insulin. Human insulin is the purest insulin and has the lowest antigenic effect. Human insulin is recommended for all newly diagnosed Type I diabetics, Type II diabetics who need short-term insulin therapy, the pregnant client, and diabetic clients with insulin allergy or severe insulin resistance. FJRC.MS.MetabolicAlterations
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Insulin pumps are small, externally worn devices that closely mimic normal pancreatic functioning. Insulin pumps contain a 3 ml sringe attached to a long (42 inch), narrow-lumen tube with a needle or Teflon catheter is inserted into the subcutaneous tissue (usually on the abdomen) and secured with tape or a transparent dressing. The needle or catheter is changed at least every 3 days. The pump is worn either on a belt or in a pocket. The pump uses only regular insulin. Insulin can be administered via the basal rate (usually 0.5-2.0 units/hr) and by a bolus dose (which is activated by a series of button FJRC.MS.MetabolicAlterations pushes) prior to each meal.
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All types: polyuria, polydipsia, polyphagia, fatigue, blurred vision, susceptibility to infection Type I: anorexia, nausea, vomiting, weight loss Type II: obesity; frequently no other symptoms FJRC.MS.MetabolicAlterations
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Diagnostic tests Fasting blood sugar a level of 140 mg/dl or greater on at least two occasions confirms diabetes mellitus may normal in Type II diabetes
Postprandial blood sugar: elevated Oral glucose tolerance test (most sensitive test): elevated Glycosolated hemoglobin (hemoglobin A) elevated
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Administer insulin or oral hypoglycemic agents as ordered; monitor for hypoglycemia, especially during period of drug’s speak action Provide special diet as ordered Ensure that the client is eating all meals. If all food is not ingested, provide appropriate substitutes according to the exchange lists or give measured amount of orange juice to substitute for leftover food; provide snack later in the day.
Monitor urine sugar and acetone (freshly avoided specimen) Perform finger sticks to monitor blood glucose levels as ordered (more accurate than urine tests). FJRC.MS.MetabolicAlterations Observe for signs of hypo/hyperglycemia.
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Provide meticulous skin care and prevent injury. Maintain I&O; weight daily. Provide emotional support; assist client in adapting to change n lifestyle and body image.
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Observe for chronic complications and plan care accordingly. Atherosclerosis: leads to coronary artery disease, MI, CVA, and peripheral vascular disease. Microangiopathy: most commonly affects eyes and kidneys Kidney disease recurrent pyelonephritis diabetic nephropathy
Ocular disorders 1. premature cataracts 2. diabetic retinopathy
Peripheral neuropathy 1. affects peripheral and autonomic nervous systems. 2. causes diarrhea, constipation, neurogenic FJRC.MS.MetabolicAlterations bladder, impotence, decreased sweating
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Provide client teaching and discharge planning concerning Disease process Diet Client should be able to plan meals using exchange lists before discharge emphasize importance of regularity of meals; never skip meals
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Insulin How to draw up into syringe gently roll vial between palms of hands draw up insulin using sterile technique.
Injection technique systematically rotate sites to prevent lipodystrophy (hypertrophy or atrophy of tissue) insert needle at a 45˚ or 90˚ angle depending on amount of adipose tissue
May store current vial of insulin at room temperature; refrigerate extra supplies. Provide many opportunities for return demonstration
Oral hypoglycemic agents stress importance of taking the drug regularly FJRC.MS.MetabolicAlterations avoid alcohol intake while on medication
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Urine testing (not very accurate reflection of blood glucose level) May be satisfactory for Type II diabetics since therapy are more stable. Use Clinitest, Test-tape, Diastix for glucose testing Perform tests before meals and at bedtime. Use freshly voided specimen.
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Be consistent in brand of urine test used. Report result in percentages. Report results to physician if results are greater than 1%, especially if experiencing symptoms of hyperglycemia Urine testing for ketones should be done by Type I diabetic clients when there is persistent glycosuria, increased blood glucose levels, or if the client is not feeling well (Acetest
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Blood glucose monitoring Instruct 1. Use for Type I diabetic clients since it gives exact blood glucose level and also detects hypoglycemia. client in fingerstick technique, use of monitor device (if used), and recording and utilization of test results. FJRC.MS.MetabolicAlterations
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General care perform good oral hygiene and have regular dental exams. have regular eye exams. care for “sick days” (e.g., cold or flu) a. do not omit insulin or oral hypoglycemic agents since infection causes increased blood sugar. b. notify physician. c. monitor urine or blood glucose levels and urine ketones frequently. d. if nausea and/or vomiting occurs, sip on clear liquids with simple sugars. FJRC.MS.MetabolicAlterations
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Foot care wash feet with mild soap and water and p at dry. apply lanolin to feet to prevent drying and cracking cut toenails straight across avoid constricting garments such s garters. wear clean, absorbent socks (cotton or wool) purchase properly fitting shoes and bread new shoes in gradually never go barefoot inspect feet daily and notify physician if cuts, blisters, or breaks in skin occur.
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Exercise undertake regular exercise; avoid sporadic, vigorous exercise food intake may need to be increased before exercising exercise is best performed after meals when the blood sugar is rising
Complications learn to recognize signs and symptoms of hypo/hyperglycemia eat candy or drink orange juice with sugar added for insulin reaction (hypoglycemia).
Need to wear a Medic- Alert bracelet FJRC.MS.MetabolicAlterations
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Sel ec ted End oc rin e PHA RM ACO LOGY
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En docrine Medic ations Enhance re-absorption of water in the kidneys Used in DI Desmopressin and Lypressin intranasally Pitressin IM FJRC.MS.MetabolicAlterations
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En docrine Medic ations SIDE-effects Flushing and headache Water intoxication
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Th yr oid Me dic atio ns
Levothyroxine (Synthroid) and Liothyroxine (Cytomel) Replace hormonal deficit in the treatment of HYPOTHYROIDSM FJRC.MS.MetabolicAlterations
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Th yr oid Me dic atio ns Nausea and Vomiting Signs of increased metabolism= tachycardia, hypertension FJRC.MS.MetabolicAlterations
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Th yr oid Me dic atio ns
Monitor weight, VS Instruct client to take daily medication the same time each morning WITHOUT FOOD FJRC.MS.MetabolicAlterations
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Th yr oid Me dic atio ns Advise to report palpitation, tachycardia, and chest pain Instruct to avoid foods that inhibit thyroid secretions like cabbage, spinach and radishes FJRC.MS.MetabolicAlterations
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ANT I-Th yro id Me dications Methimazole (Tapazole) PTU (prophylthiouracil) Iodine solution- SSKI and Lugol’s solution FJRC.MS.MetabolicAlterations
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ANT I-Th yro id Me dications N/V Diarrhea AGRANULOCYTOSIS Most important to monitor FJRC.MS.MetabolicAlterations
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ANT I-Th yro id Me dications Monitor VS, T3 and T4, weight The medications WITH MEALS to avoid gastric upset Instruct to report SORE THROAT or unexplained FEVER Monitor for signs of hypothyroidism. Instruct not to stop abrupt FJRC.MS.MetabolicAlterations
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Used to decrease the vascularity of the thyroid T3 and T4 production diminishes Given per orem, can be diluted with juice Use straw FJRC.MS.MetabolicAlterations
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STER OI DS Replaces the steroids in the body Cortisol, cortisone, betamethasone, and hydrocortisone FJRC.MS.MetabolicAlterations
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STER OI DS Side-effects HYPERglycemia Increased susceptibility to infection Hypokalemia Edema FJRC.MS.MetabolicAlterations
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STER OI DS Side-effects If high dosesosteoporosis, growth retardation, peptic ulcer, hypertension, cataract, mood changes, hirsutism, and fragile skin FJRC.MS.MetabolicAlterations
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STER OI DS Nursing responsibilities 1. Monitor VS, electrolytes, glucose 2. Monitor weight edema and I/O FJRC.MS.MetabolicAlterations
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STER OI DS 3. Protect patient from infection 4. Handle patient gently 5. Instruct to take meds WITH MEALS to prevent gastric ulcer formation FJRC.MS.MetabolicAlterations
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STER OI DS Nursing responsibilities 6. Caution the patient NOT to abruptly stop the drug 7. Drug is tapered to allow the adrenal gland to secrete endogenous hormones FJRC.MS.MetabolicAlterations
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Hyp oth yro idism Hyposecretion of thyroid hormones Common causes: Iodine deficiency, Hashimotos Manifestations: related to hypometabolic state: constipation, weight gain, cold intolerance, poor appetite, mental slowness Nursing Management: Provide warm environment LOW calorie diet, HIGH fiber Avoid sedatives Drugs: Hormone FJRC.MS.MetabolicAlterations 175 replacement
Hyp ert hyroid ism Hyper-secretion of thyroid hormones Common cause: Graves, Toxic goiter Manifestation: increased metabolism: weight loss, diarrhea, heat intolerance, hypertension Nursing Management:
Adequate rest and sleep Cool environment HIGH calorie foods Eye care FJRC.MS.MetabolicAlterations Drugs: anti-thyroid: PTU and
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EXO -P AN CRE AT IC AN D BI LIARY DI SO RDE RS
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PAN CREA TIT IS Acute inflammation of the pancreas associated with auto-digestion Enzymes secreted destroy the tissue of the pancreas Consistent alcohol intake is the most causative factor
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CHO LECY STI TI S/ CHO L EL ITH IA SI S Cholecystitis: inflammation of the gallbladder Cholelithiasis: occurs when gallstones are formed due to bile that is usually stored in the gallbladder hardening into stonelike material Cholesterol, bilirubin, and calcium precipitates FJRC.MS.MetabolicAlterations
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HE PAT IC DIS OR DE RS
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