Materi-11-efek-narkoba-pemaparan-bnn.pdf
This document was uploaded by user and they confirmed that they have the permission to share it. If you are author or own the copyright of this book, please report to us by using this DMCA report form. Report DMCA
Overview
Download & View Materi-11-efek-narkoba-pemaparan-bnn.pdf as PDF for free.
More details
- Words: 391
- Pages: 33
HARI NUGROHO, MD UPT TERAPI & REHABILITASI BADAN NARKOTIKA NASIONAL
Permasalahan Penyalahgunaan Narkoba •
• • •
Indonesia pasar potensial peredaran gelap narkoba Jumlah penyalahguna semakin meningkat Adiksi merupakan masalah Public Health Adiksi adalah “Brain Disease”
Addiction Medical DRUGS
Homelessnes s Crime Violence
Social
Neurotoxicity AIDS, Cancer Mental illness, Hepatitis
Economic Health care Productivity Accidents
Estimated Economic Cost to Society Due to Substance Addiction: IllegalAbuse drugs:and $181 billion/year Alcohol: Tobacco: Total:
$185 billion/year $158 billion/year $524 billion/year
Surgeon General’s Report, 2004; ONDCP, 2004; Harwood, 2000.
Why Do People Take Drugs in The First Place? To Feel Good
To Feel Better
To have novel: feelings sensations experiences AND to share them
To lessen: anxiety worries fears depression hopelessness
Your Brain on Drugs in the 1980’s
Your Brain on Drugs Today
YELLOW shows places in brain where cocaine binds (e.g., striatum)
Fowler et al., Synapse, 1989.
➢ ➢ ➢ ➢
Addiction is Like Other Diseases… It is preventable It is treatable It changes biology If untreated, it can last a lifetime
Decreased Brain Metabolism in Drug Abuser
Decreased Heart Metabolism in Heart Disease Patient High
Low
Healthy Diseased Brain/ Diseased Heart Heart Cocaine Abuser Research supported by NIDA addresses all of these components of addiction.
Healthy Brain
Drugs can be “Imposters” of Brain Messages
Movement Motivation
Dopamine
Addiction
Reward & well-being
dopamine transporters
But Dopamine is only Part of the Story • – •
– •
Scientific research has shown that other neurotransmitter systems are also affected: Serotonin Regulates mood, sleep, etc.
Glutamate Regulates learning and memory, etc.
Functionally… Dopamine D2 Receptors are Decreased by Addiction
Cocaine
Met h Alcoho l
Heroin
Control
Addicted
D A D 2 R e c e p to r A v ai
Konsekuensi dari perubahan di otak
•
Gangguan mental dan perilaku
[C-11]d-threo-methylphenidate
DAT Recovery with prolonged abstinence from methamphetamin e
Normal Control
hig h
Methamphetamine Abuser (1 month abstinent)
Methamphetamine Abuser (14 months abstinent) Volkow et al., J. Neuroscience, 2001.
low
Pengaruh Terhadap Hati • • •
Hepatitis B Hepatitis C Sirrosis hati
Kanker hati
HIV / AIDS • • • •
Terutama IDU Infeksi Oportunistik Butuh dukungan keluarga Rutin terapi ARV
4 dari 10 kematian AIDS berhubungan dengan Drug Abuse
Wajah drugs abuser
In Treating Addiction… We Need to Keep Our Eye on the Real Targets! Abstinence
Functionality in Family, Work and Community
TERIMA KASIH
Permasalahan Penyalahgunaan Narkoba •
• • •
Indonesia pasar potensial peredaran gelap narkoba Jumlah penyalahguna semakin meningkat Adiksi merupakan masalah Public Health Adiksi adalah “Brain Disease”
Addiction Medical DRUGS
Homelessnes s Crime Violence
Social
Neurotoxicity AIDS, Cancer Mental illness, Hepatitis
Economic Health care Productivity Accidents
Estimated Economic Cost to Society Due to Substance Addiction: IllegalAbuse drugs:and $181 billion/year Alcohol: Tobacco: Total:
$185 billion/year $158 billion/year $524 billion/year
Surgeon General’s Report, 2004; ONDCP, 2004; Harwood, 2000.
Why Do People Take Drugs in The First Place? To Feel Good
To Feel Better
To have novel: feelings sensations experiences AND to share them
To lessen: anxiety worries fears depression hopelessness
Your Brain on Drugs in the 1980’s
Your Brain on Drugs Today
YELLOW shows places in brain where cocaine binds (e.g., striatum)
Fowler et al., Synapse, 1989.
➢ ➢ ➢ ➢
Addiction is Like Other Diseases… It is preventable It is treatable It changes biology If untreated, it can last a lifetime
Decreased Brain Metabolism in Drug Abuser
Decreased Heart Metabolism in Heart Disease Patient High
Low
Healthy Diseased Brain/ Diseased Heart Heart Cocaine Abuser Research supported by NIDA addresses all of these components of addiction.
Healthy Brain
Drugs can be “Imposters” of Brain Messages
Movement Motivation
Dopamine
Addiction
Reward & well-being
dopamine transporters
But Dopamine is only Part of the Story • – •
– •
Scientific research has shown that other neurotransmitter systems are also affected: Serotonin Regulates mood, sleep, etc.
Glutamate Regulates learning and memory, etc.
Functionally… Dopamine D2 Receptors are Decreased by Addiction
Cocaine
Met h Alcoho l
Heroin
Control
Addicted
D A D 2 R e c e p to r A v ai
Konsekuensi dari perubahan di otak
•
Gangguan mental dan perilaku
[C-11]d-threo-methylphenidate
DAT Recovery with prolonged abstinence from methamphetamin e
Normal Control
hig h
Methamphetamine Abuser (1 month abstinent)
Methamphetamine Abuser (14 months abstinent) Volkow et al., J. Neuroscience, 2001.
low
Pengaruh Terhadap Hati • • •
Hepatitis B Hepatitis C Sirrosis hati
Kanker hati
HIV / AIDS • • • •
Terutama IDU Infeksi Oportunistik Butuh dukungan keluarga Rutin terapi ARV
4 dari 10 kematian AIDS berhubungan dengan Drug Abuse
Wajah drugs abuser
In Treating Addiction… We Need to Keep Our Eye on the Real Targets! Abstinence
Functionality in Family, Work and Community
TERIMA KASIH
More Documents from "Mirla Lianesa"
Materi-11-efek-narkoba-pemaparan-bnn.pdf
May 2020 0
Tipos De Pensamiento (para El Taller).docx
June 2020 4