Macro For Micro[1][1][1]

Microbiology

MACRO for MICRO

Adenovirus and Human Papilloma Virus

Date Due: April 11, 2007 Submitted By: Michelle Cali Jessica Cardona Kristina Kastelanac Eileen Suwanda Laurie Teitelman

Microbe

Distinguishing Lab. Disease S's & Sx's of disease Virulence features Tests - Clinical factors Adenovirus -Naked capsid -Microscopy: -Causes a 1)Acute febrile -Stable to -Used as a Owl’s Eye range of detergents, pharyngitis  do vector for inclusion diseases from rapid strep test to drying, gene body, as in URI to confirm it is not strep chlorine, GIT treatment CMV, but no hemorrhagic acids throat cytomegaly cystitis 2)Acute respiratory -Spread via Prevention: with -Causes 3 types disease  cervical poorly Antibodies adenovirus of infection: chlorinated lymphadenopathy protect from -Leukocytosis 1)lytic swimming 3)Conjunctivitis re-infection and 2)latent pools “shipyard eye”  by the same increased CRP 3)transforming associated with -Infect serotype only (not in humans) swimming pools & epithelial -Most infections dust/debris cells lining are 4)Gastroenteritis  the asymptomatic second only to respiratory rotavirus as cause of & enteric organs acute GE in kids

Human Papilloma Virus

-Naked -Microscopy: capsid, non PAP smear & encapsulated characteristic histological changes -Presence of Prevention: koilocytes -Safe sex, -Apply topical avoid contact 5% acetic with infected acid & area patient, wear whitens sandals in public pool areas, keep immune system balanced

5)Systemic infection of immunocompromise d can cause hepatitis and/or pneumonia! 6)Other hemorrhagic cystitis 1)Genus 1)Common flat wart papilloma –HPV  keratinized skin, surface studded with a)Cutaneous – black dots/capillaries verruca Usually painless, but warts plantar are painful 2)Oral papillomas  b)Mucosa – m/c single, rarely genital, oral, recur, any age conjunctival 3)Laryngeal papillomas, & papilloma m/c cervical cancer epithelial tumor on the larynx; common to recur after tx, bimodal incidence, hoarseness or abnormal cry, ↑ risk with voice use & smoking 4)Condylomata acuminate (anogenital warts) HPV-6, HPV 11, STD, vaginal birth, or unknown transmission 5) Cervical dysplasia

-Transfer via fomites as an STD, via birth canal, or systemic spread by chewing on warts -Common plantar & flat verruca are m/c in kids & teens -Access through breaks in the skin & mucosa -Transformat ion occurs b/c proteins produced by certain strains (HPV-16,18) bind & inactivate

& cancer (2nd most common cancer in USA) HPV-16, -18, *Need cofactors to progress to cancer

Interventions: Naturopathic Intervention Support for modality The most important nutritional Supplements: Nutrition

tumor suppressor molecules so cells grow uncontrollab ly -Cause lytic, chronic, latent, or transformin g infections

Reference

form to aid with HPV is to keep a) Lactobacillus is the 1. Garcia-Closas R, et. Al. our immune system balanced. healthy bacteria that The Role of diet and nutrition inhabits the intestines in cervical carcinogenesis: a Supplements: and vagina and protect us review of recent evidence. against unhealthy Int J Cancer. 2005, a) Lactobacillus organisms. Along with 117(4):629-37. acidophilus improving GI functions, it b) High dose VitaminC & is a great immune system 2. Giuliano AR, et. Al. Dietary Vitamin E booster. intake and risk of persistent b) Vitamin C is a water human papillomavirus (HPV) Dietary modifications: soluble antioxidant infection:the Ludwig McGill a) Increase Betavitamin. It is important in HPV Natural History study. J cryptoxanthing/ hydroxy- forming collagen, Infect. Dis. 2003; 188(10): beta-carotene intake by cartilage, muscle and 1508-16 consuming vegetables and blood vessels and helps fruits such as papaya, with immune boosting mango, peaches, oranges, effects (key for tangerines, bell peppers, prevention). Vitamin E is corn and watermelon. It is a fat soluble vitamin that also found in some yellow acts as an antioxidant by colored animal products protecting tissues from such as egg yolk and damage caused by free butter. Supplemental form radicals. may also be used. Dietary modifications: a) Beta-cryptoxanthin is a b) Reducing sugars, refined strong antioxidant foods, (weaken the containing Vitamin A, immune system), reducing preventing free radicals red meat, and drinking from damaging cells and plenty of water to remove DNA. Especially important toxins from the system in boosting immunity to help prevent HPV. In order to absorb it from the diet, it is essential that the diet contains fat since it is a fat-soluble substance.

Botanical Medicine

Garlic extract – lipid garlic extract applied to the lesion(s) bid has been proven effective in the complete recovery of varucca/warts in all patients treated within 1-2 weeks

Garlic - Mechanism of 1.Dehghani K., Healing action is still unknown effect of garlic extract on however it is suspected warts and corns, Int J that the immune Derinatot 2005-, enhancing properties 44:612.615. of garlic were a major contributor to the 2. Cooper, R., Morre, J.,

(versus the aqueous garlic extract which had moderate benefit). Documentation of traditional use has also proven effective. [1]

healing effect. This Morre, D. (2005). hypothesis is Medicinal Benefits of congruent with the Green Tea: Part II: Review finding that in patients of Anticancer Properties. with multiple warts, THE JOURNAL OF warts adjacent to the ALTERNATIVE AND Green tea extract ones being treated COMPLEMENTARY polyphenon E; poly E and were also healed. MEDICINE. 11 (4) pp. 639– (-)-epigallocatechin-3-gallateGreen tea – antioxidant 652 [EGCG]) delivered in a form effects are suspected. of ointment or capsule were 3. U.S. Department of both effective in treating Podophyllin Health and Human cervical HPV (69% response Podophyllin works by Services (2002). Sexually rate with any form of tea stopping cell growth at Transmitted Diseases extract treatment versus the site of application. Treatment Guidelines 10% in the comparison – no 2002 (CDC Publication treatment – control group). Vol. 51, No. RR-6), pp. 53– [2] 57. Atlanta: U.S. Department of Health and Podophyllin resin - Applied Human Services. to genital warts in the form of a lotion has been shown to be effective in resolving genital lesions (wet areas). Less effective applied on dry skin. Applied for 4 hours a day for 6 weeks has shown positive effects. [3] Homeopathy 2 remedies: 5 specific rubrics: Thuj: warts or tumors in the Female genitalia/sex, face or eyelids; warts on the condylomata, vagina. hands and fingers; warts and skin tags and any Female genital/sex, tumors of the skin excrescences. Nit-ac: ulceration of the mucous membranes; eruptions, herpes, warts, fissures about the lips, especially at the corners of the mouth; rectal warts; genital warts; warts at extremities TAM

Male genitalia/sex, condylomata, and around anus. Skin, excrescences, condylomata.

Schroyens, F. Synthesis Repertorium Homeopathicum Syntheticum Edition 9.1 (2004). Homeopathic Book Publishers. Morrison, R. Desktop Guide to Keynotes and Confirmatory Symptoms (1993). Hahnemann Clinic Publishing.

Skin, warts, flat/venereal. SP9 – resolves damp heat, Damp-Heat in Liver Maciocia, G. Diagnosis in regulates spleen, benefits - genital warts on penis Chinese Medicine: A lower burner or vulva Comprehensive Guide. GB34 – moves liver qi, - red tongue w/ redder 2004. Elsevier Ltd. resolves liver damp heat sides, sticky yellow REN12 / UB 20 – tonify coating Maciocia, G. The Practice spleen, resolve dampness, - wiry-slippery-rapid of Chinese Medicine. pulse 1994. Pearson Needle perpendicularly in Professional Ltd. the centre of the wart to the (anytime there is base, then ‘fast and heavy dampness we also Medical Acupuncture: A

twirling with lift-thrusting’, need to look into the then remove needle slightly spleen!) and do the same thing

Western Scientific Approach. Edited by Filshie, J & White, A. 1998. Harcourt Brace and Company Ltd. Hydrotherap Hot foot baths are good for The hot water dilates Boyle, Wade N.D., Saine, y or plantar warts on the feet. blood vessels and Andre N.D. Lectures in Counseling Immersion of feet and increases blood flow to Naturopathic or Physical ankles in water that is the area. The Hydrotherapy. Eclectic Medicine between 104-110F for 10-30 increased hydration of Medical Publications. minutes. Once feet are the skin softens the 1988. pp 69-71. removed from bath, cold plantar warts so that water can be poured over other therapies may be them briefly, then dry with more effective in towel. removing them. http://www.utoronto.ca/ During the hot phase health/healthtips/warts/ Hot/cold contrast showers: 1 circulation increases to warts.htm and a half minutes hot, then periphery then in the 30 seconds cold. This is cold phase constriction Differential diagnosis done three times starting occurs. This pumping class notes: female with hot then cold, hot then action back and forth genital section with Dr. C. cold, hot then ending with increases removal of Proctor. Lecture on cold. Water should be as toxic products of February 14, 2007. hot/cold as the patient can infection and increases tolerate. healing. Therefore boosting the immune system so that the body can better defend against current warts and potentially defend against reoccurrence. This follows the Counseling can be done and naturopathic principle educating patients on of doctor as teacher avoiding skin to skin and will on a small contact, so transmission to scale reduce the others is limited. Safer sex occurrence of warts in practices can be discussed the population. so that genital wart transmission is reduced. (eg. Condoms have been seen to reduce transmission).

http://www.healthbanks .com/PatientPortal/Public /ArticlePromoted.aspx? ArticleID=HW5hw64902