Lycopene And Cardiovascular Disease

Lycopene and Cardiovascular Disease Presented by : Anjali Tiwari

Introduction 1. Lycopene and CVD disease , 2. Plasma lycopene ,other caoteniods ,and retinol and the risk of CVD in men . 3. Plasma lycopene ,other caoteniods ,and retinol and the risk of CVD in women .

What is lycopene ? • Lycopene is hydrocarbon carotenoid which has received attention for its potential role in preventing prostate cancer and CVD disease in humans . • In 1989 Di Mascio et al showed that lycopene has strongest oxygen quenching capacity of several carotenoids , with alpha –carotene ,beta –carotene ,and lutein next in capacity.

In study 1 it include st

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Introduction Food sources and absorption of lycopene Lycopene and smoking Biological activity of lycopene Epidemiologic Evidence

Study 2

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• Subject and methods • Result • Discussion

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In subjects and method of 2nd &3rd study include • Study population :The WHS is ongoing randomized ,double –blind ,placebo controlled 2x2 factorial trial of the relationship between low - dose aspirin vitamin E and primary prevention of CVD & cancer. 39,876 female US health professionals aged > 45 y in 1992 ,were postmenopausal or not intending to became pregnant , and had no history of MI , stroke ,transient ischemic attack or cancer were enrolled in study.

Subject & method of 2nd & 3rd study……. Fasting baseline blood samples were collected from 28,345 (71%) participants and stored in liquid nitrogen until analyzed .

Subject & method of 2nd & 3rd study……. • Study population of 3rd study : The PHS began as trial in 1982 of 22,071 men testing aspirin and beta carotene in the primary prevention f cancer and CVD ,it was completed in 1995. PHS 2 was initiated as randomized ,double blind , placebo- controlled ,2x2x2x2 factorial trial testing the benefits and risk of vitamin E ,VIT C a multivitamin , and beta carotene in the primary prevention of cancer ,CVD and other chornic disease in male physicians aged >50 y ,including 7641 original physicians from the PHS plus 7000 new Physicians were recruited. fasting blood samples were collected from PHS in 1996

Subject & method of 2nd & 3rd study……. • Blood assays :Baseline blood samples from cases & control were thawed and assayed for total lycopene ,other carotenoids and retinol at Our lady of Mercy Medical centre Bronx (NY). All assays was quantified by conventional method .Plasma lipid including total cholesterol and HDL cholesterol , using commercially available diagnostic kits (sigma –aldrich chemical Co , St louis , Mo) .

Subject & method of 2nd & 3rd study……. • Blood Assays….. Plasma total cholesterol was assayed because plasma lipoprotein are non – specific carrier for all the caroteniods in plasma &to date ,total cholesterol appears to be best way to control for confounding effects due to differences in lipoprotein concentration between subjects .

Subject & method of 2nd & 3rd study……. • Baseline covariates :Women from WHS and Men from PHS provided self –reported dad on age (in ) ,weight & height (converted to body mass index ; in kg /m2 ), smoking status (categorized as never , former , or current ), alcohol use (categorized as rarely or never ,<1drink /d, or .1drink /d) ,frequency of exercise (categorized as rarely or never , <3d/wk ,3-4d/wk or .5 d/wk), parental history of MI at <60 y of age (yes or no ), and history of hypercholesterolemia (yes or no) .

Subject & method of 2nd & 3rd study……. • Data analyses: Men from PHS & women from WHS were first compared to case control status by using mean value or proportion of baseline coronary disease risk factors and biochemical makers . Measurements of plasma lycopene concentration were divided into quartiles based on overall distribution of plasma lycopene among the 499 for men in controls &483 for women in controls.

Results of 2 study nd