Lecture 7_synaptic Transmission

Synaptic Transmission

Christian Kreipke, PhD [email protected]

Outline  Overview of Synaptic Transmission  Signaling at the Nerve-Muscle Synapse  Synaptic Integration  Second Messengers  Transmitter Release  Neurotransmitters

Overview

Part I

Gap Junction

Synaptic transmission at chemical synapses

Neurotransmitters

Signaling at the NerveMuscle Synapse

Part II

Neuromuscular Junction

Synaptic potential is highest at the end plate region

Ach-gated channels

Binding of ACh in a postsynaptic muscle cell opens channels permeable to both NA+ and K+

Synaptic Integration

Part III

The combination of excitatory and inhibitory synaptic connections mediating the stretch reflex is typical of circuits in the CNS

Common types of synapses

Example: Glu Three classes of Glutamate receptors

Ligand gated channels

Excitatory and Inhibitory currents

Second Messengers

Part IV

Receptor Classification

Typical second-messenger systems

cAMP cycle

Protein Kinases

Phospholipid hydrolysis

Location of second messenger synapses

Example of integrating neurotransmitters with ion channels

Terminating protein kinases

The Big Picture

Transmitter Release

Part V

Steps of cycling synaptic vesicles

Examples of Synaptic Vesicle Proteins

Axo-axonic synapses

Neurotransmitters

Part VI

Brain peptides organized by tissue localization

Families of Neuroactive Peptides