Inhibitors They Slow Down Enzyme Catalyzed Reactions By Fitting Into

Inhibitors They slow down enzyme catalyzed reactions by fitting into sites on the enzyme. 2 Types of inhibitors 1. Competitive 2. Non-Competitive Competitive • Fit into active site • Have a shape similar to, but not the same as the substrate • Block the substrate from entering the active site • Prevent the formation of enzyme substrate • Have an affect that can be reversed by adding more substrate. Eg Malonic acid fits into the active site of an enzyme involved in respiration in the Mitochondria Non-Competitive • Do not fit into the active site • Fit onto a site elsewhere on the enzyme • Cause the active site to change shape so that it is no longer complementary in shape to the substrate

• Have an affect that cannot be reversed Non-Competitive inhibitors are often produced by a series of reactions inside cells. Each reaction is catalysed by a different enzyme- (GlycolysisLinear Pathways) When there is enough product, it inhibits enzymes at the beginning of the process, so slowing down or stopping production. This is an example of reversible inhibitors however some non-competitive inhibitors are irreversible and permanently change the active site.