Immunodeficiency Immunodeficiency and and autoimmunity autoimmunity
Immunodeficiency diseases • Conditions where the defence mechanisms of the body are impaired, leading to repeated microbial infections and sometimes enhanced susceptibility to malignancies
• May involveHumoral immunity or Cell mediated immunity or Both or Phagocytosis or complement
• Immunodeficiencies can be classified as Primary imm.defi-arise from abnormalities in the development of immune mechanisms Secondary imm.defi-are due to disease,drugs,nutritional inadequacies,etc
Primary immunodeficiencies • Humoral immunodeficiencies-X linked agammaglobulinemia • Cellular immunodeficiencies-Digeorge’s syndrome • Combined immunodeficiencies-Neselof syndrome • Complement component deficiencies-Neisserial infectns with deficiency of C6,C7,C8 • Disorders of phagocytosis-Chediak –Higashi syndrome,Lazy leucocyte syndrome
Secondary immunodefiencies • AIDS • Hodgkin’s lymphoma • Immunosuppressive agents
Treatment • Administration of immunoglobulins,thymus graft,bone marrow graft