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Gene expression is noisy cfp yfp (Identical promoters)
See also related work: Ozbudak et al, Nat. Gen. 2002 Paulsson, J., Nature 2004 Raser & O’Shea, Science 2004. Pedraza & van Oudenaarden,
With P. Swain, E. Siggia, & A.J. Levine, Science 2002
The Competence Circuit is Excitable ComS nullcline
ComK nullcline ClpP ClpP ClpC ClpC
log (ComS)
MecA
+
Stabl Saddl Unstab
ComK ComK
-
comK
P
log (ComK)
comK
ComS ComS
comS
P
comS
Competence Circuitry and Differentiation
Gene expression is noisy cfp yfp (Identical promoters)
See also related work: Ozbudak et al, Nat. Gen. 2002 Paulsson, J., Nature 2004 Raser & O’Shea, Science 2004. Pedraza & van Oudenaarden,
With P. Swain, E. Siggia, & A.J. Levine, Science 2002
The Competence Circuit is Excitable ComS nullcline
ComK nullcline ClpP ClpP ClpC ClpC
log (ComS)
MecA
+
Stabl Saddl Unstab
ComK ComK
-
comK
P
log (ComK)
comK
ComS ComS
comS
P
comS
Competence Circuitry and Differentiation
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