Genetically Modified Crops

•Transgenic plants possess a gene or genes that have been transferred from a different species. •As their genome is getting modified they are referred to as genetically modified plants.

1.Agrobacterium mediated gene transfer: 2.Direct gene transfer

Micro injection Particle gun delivery

Antigens or antibodies expressed in plants can be administered orally as any edible part of the plant, or by parenteral route (such as intramuscular or Intravenous injection) after isolation and purification from the plant tissue.

DESIRED ANTIGEN + Viral coat protein (carrier) fusion Recombinant viruses infection Plants elicit Immunogenecity

•

•

•

The first report of the production of edible vaccine (a surface protein from Streptococcus) in tobacco, appeared in 1990 . Vaccine against acute watery diarrhea caused by E.coli & Vibrio cholerae is produced from tobacco. Injecting mink with extracts of plants infected with a cowpea mosaic virus, that expresses a mink enteritis antigen gene, protects the animal against subsequent virus challenge.

TOBACCO

BLACK EYED BEAN PLANTS

•Insulin and GAD have been produced in potato and tobacco, respectively.

•To direct the delivery of plant-synthesized insulin to the gut-associated lymphoid tissue .

•Over 20 million people become infected with Hepatitis B every year. • Hepatitis B is a serious disease caused by a virus that attacks the liver, and can cause lifelong infection, cirrhosis (scarring) of the liver, liver cancer, liver failure, and death.

Alzheimer’s disease (AD) is a neurodegenerative disease and the most common cause of dementia

•Thus the plant based Vaccines were proved successful in providing a technology for production and delivery of inexpensive and efficient vaccines in this World of Biotechnology. •Hence, there is no doubt to say that, “PLANTiBODIES

ANTIBODIES”

ARE

Thank “u”………..