Furosemide

DARIEN NICETY A. SASAN BSN III-B (o, kang nice jud ni. Kai loser ko. xD) Mechanism of Drug Data Classification Indication Action Generic Name: Furosemide

Therapeutic: anti-infective

Trade name: Lasix, Apo-Furosemide Furosemide Special

PharmacologicLoop Diuretic Pregnancy Risk Category:C

Content: Furosemide Maximum Dosage: 120 mg

» Inhibits reabsorption of sodium and chloride from the proximal and distal tubules and ascending limb of the loop of Henle, leading to a sodium-rich diuresis.

» Oral, IV: Edema associated with heart failure, cirrhosis, renal disease

» Contraindicated in patients with allergy to furosemide, sulfonamides; allergy » IV: Acute » severe renal pulmonary edema failure » hepatic coma » Oral: » pregnancy Hypertension » lactation

Pharmacokinetics

Minimum Dosage: 10mg/ml

» Precaution - with SLE - gout - diabetes mellitus

M: hepatic D: crosses placenta, enters breast milk E: feces, urine

Availability: Tablets: 20, 40, 80 mg; Oral Solution: 10mg/mL, 40mg/5mL; Injection: 10mg/mL

Contraindications

Half-Life: 30-60min

» CNS: dizziness, vertigo, paresthesias, xanthopsia, weakness, headache, drowsiness, fatigue, blurred vision, tinnitus, irreversible hearing loss » CV: orthostatic hypotension, volume depletion, cardiac arrythmias, thrombophlebitis » Dermatologic: Photosensitivity, rash, pruritus, urticaria, purpura, exfoliative dermatitis, erythema multiforme »GI: vomiting, nausea, anorexia, oral and gastric irritation, constipation, diarrhea, acute pancreatic, jaundice » GU: polyuria, nocturia, glycosuria, urinary blader spasm

Route: Oral; IV, IM Onset: 60min; 5min Peak: 60-120min; 30min Duration: 6-8hr; 2hr

Route: Oral, IM, IV

Adverse Reaction

» HEMA: leukopenia, anemia, thrombocytopenia, fluid and electrolyte imbalances, hyperglycemia, hyperuricemia » Other: muscle cramps and muscle spasms

Source: Nursing Drug Handbook, 2009. Lippincott Williams and Wilkins, Philadelphia. Pages 563-565

Source: Nursing Drug Handbook, 2009. Lippincott Williams and Wilkins,

Source: Nursing Drug Handbook, 2009. Lippincott Williams and Wilkins, Philadelphia. Pages

Source: Nursing Drug Handbook, 2009. Lippincott Williams and Wilkins, Philadelphia. Pages

Source: Nursing Drug Handbook, 2009. Lippincott Williams and Wilkins, Philadelphia. Pages

Source: Nursing Drug Handbook, 2009. Lippincott Williams and Wilkins, Philadelphia. Pages 551-552

Nursing Responsibilities Before: » Ask if patient has allergy to furosemide and sulfonamides. » Assess if pt. has SLE, gout and diabetes mellitus. » Arrange to monitor serum electrolytes hydration, liver and renal functions. » Arrange for potassium-rich diet or supplemental potassium as needed. » Observe 15 cardinal rights in giving medication. During: » Administer with food or milk to prevent GI upset. » Reduce dosage with other antihypertensives, readjust dosage gradually as BP responds. » Give early in the day so that increased urination will not disturb sleep. » Avoid IV use if oral use is possible. » Do not mix parenteral solution with highly acidic solutions with pH below 3.5 After: - Discard diluted solution after 24hrs.. Refrigerate oral solution. » Measure and record weight to monitor fluid changes. » Report loss or gain of more than 3 pounds in 1 day. » Do not expose to light, which may discolour tablet or solution. Source: Nursing Drug Handbook, 2009. Lippincott Williams and Wilkins, Philadelphia. Pages 552

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