Final Edited Sheikh Kura_tracked.docx

Running Head: MATHEMATICAL MODEL OF THE POPULATION DYNAMICS

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Mathematical Mmodel of the Population Dynamics of Staphylococcus Aaureus with Ddual-Ttransmission Ppathways in the Ppresence of Antibiotic-Bbased Therapy

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Introduction:

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Staphylococcus aureus (staph) is a member of the staphylococcaceae family that

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contains more than 50 species (Jawetz et. al., 2010;, Ochei and Kolhatkar, 2008). The staph is

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a leading opportunistic gGram-positive pathogen in human and animal medicine, causing a

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wide array of hard-to-treat infections, ranging from superficial skin and soft tissue infections (SSTIs) to life-threating invasive diseases such as brain abscess, pneumonia, endophthalmitis and sepsis (bloodstream) infection (Leonard and Markey, 2007); b. Besides this, infertility, sexual dysfunction, impotency (Esmail Khani et al., 2018) and staphylococcal food poisoning

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remain some of the immediate consequences of staph in humans, accounting for 68.2% of seminal fluid infection in male and female alike (Gupta and Probha, 2012). Meanwhile, staph primary exists as a human commensal, mostly in the anterior nares, from whence it’s able to seed infection, colonizing about a third of the world’s population (Col et .al., 2001).

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The individuals most vulnerable to staphylococcal infections are children and adults of all age who are immune compromised or who have invasive medical devices. (Cunnion, 2003).

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Transmission of infection can however be spread from skin-to-skin by having direct contact with individuals who are appropriate carriers (Straskova et. al., 2009). Sexual transfer of Saureus is evidently a new trend of transmission which has not been widely explored. Nevertheless, S-aureus still ranks second as the major cause of nosocomial blood stream infection that leads to increased mortality, morbidity, hospital stay and lost (Gravel et. aAl., 2009;; Klevens et. al., 2007). The adaptability of S-aureus to antibiotics is a significant characteristics that led to the emergence of methicillin –Resistant staphylococcus aureus (MRSA) in 1961 in the UK (Patrick et. al., 2013). The ability of S-aureus to acquire mecA gene offers then resistance to all -lactam antibiotics.

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