Epatoprotective Effect Of Reen Tea (camelia Sinensis1
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Hesham A. El- Beshbishy Biochemistr y Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo, Egypt
The aim of this study was to investigate the
possibility of green tea polyphenol, as a novel protective agent for Hepatic injury from chemotherapeutic drug
Herbal medicines derived from plant extracts
are being increasingly utilized to treat a wide variety of clinical disease Protective effects of natural antioxidants against drug-induced toxicities especially whenever free radical generation is involved
Flavonoids are group of polyphenolic
compounds that occur widely in fruit, vegetables, tea, cocoas and red wine
Fresh tea leaves are rich in flavanol
monomers known as catechins such as epicatechins
Epicatechins (antioxidant present in green
tea) scavenge a wide range of free radicals including the most active hydroxyl radical. Epicatechins are effective scavengers of physiologically active reactive oxygen and nitrogen species Epicatechins may chelate metal ions, especially iron and copper
Tamoxifen is prescribed for women with
hormone-receptor-positive breast cancer before and after menopause. Tamoxifen is an anti-estrogen drug that was developed over 30 years ago. It is used widely to treat breast cancer. It is also used to treat a variety of other conditions, including infertility.
Most breast cancers need supplies of the
female hormone estrogen to grow. Cancer cells have sex hormones[estrogen] receptors on their surface called estrogen-receptorpositive (ER-positive) and tamoxifen is most effective against these cancers.
The most common side effects, apart from
nausea, are hot flushes and sweats, particularly at night. Long-term side effects Studies have shown that post-menopausal
women who take tamoxifen over a long period of time may have a very slightly increased risk of developing cancer of the lining of the womb (endometrial cancer).
Animals 1.5% green tea
extract (GTE). This solution was provided to rats as their sole source of drinking water.
Forty adult female
albino rats, weighing 120-170gm were used as experimental animals in this study.
Group 1: Normal control untreated rats. Group 2: TAM -intoxicated rats: Rats were treated
with TAM in a dose of 45 mg/ Kg.day, i.p. , for 7 successive days Group 3: GTE rats: Rats were orally administered 1.5% green tea extract (GTE) as their sole source of drinking water for 18 days. Group 4: TAM-GTE rats: Rats were orally administered 1.5% GTE as their sole source of drinking water 4 days before and 14 days after TAM intoxication (in a dose identical to group 2) as protection against liver injury induced by TAM.
indicator of lipid peroxidatio n
levels of antioxidant enzyme activities
liver damage
Paired t-test was carried out to compare
populations A 0.001 level of probability was used as the criterion for significance.
=gr.3 =gr.4
gr.3 gr.3
gr.4
gr.4
Gr.1
Gr.2
Gr.3
Gr.4
Gr.3
Gr.4 Gr.3 Gr.1
Gr.2 Gr.1
Gr.2 Gr.4
sGPT
sGOT
Gr.1
Gr.2
Gr.3
Gr.4
It was obvious that tamoxifen in toxic doses
lead to oxidative liver damage The oxidation process resulted as a result of TAM-intoxication leads to release of iron ions. These ions, become more reactive in liver. Free irons ions participate in generation of hydroxyl radicals which are the most active reactive oxygen species (ROS) and they react readily with most cellular components
Tamoxifen act here
The levels of antioxidant enzyme
activities in liver homogenates (GST, GPX, SOD and CAT) and GSH were significantly improved upon treatment of TAM-intoxicated rats with 1.5% GTE whereas the level of TBARS were significantly decreased comparable to TAM-intoxicated group.
The destruction and degradation of
phospholipids hydroperoxides are carried out by GPX The decreased GPX level of TAM-intoxicated rats, leads to an increase of toxic level to the cells The decreased activities of GPX and SOD in liver homogenate of TAM-intoxicated rats may be due to oxidative stress induced in activation and/or exhaustion. The decreased GPX activity leads to H2O2 accumulation in the liver which inactivates SOD. SOD GSH plays as protein-bound glutathione and by generation of ascorbate or tocopherol in liver The decreased hepatic GSH in TAM-intoxicated
blocking oxidative damage through lipid peroxidation and protein oxidation, green tea extract
By
can prevent the loss of membrane permeability and dysfunction of cellular proteins and decreases the endogenous level of hydroxyl radical
The data achieved from this study revealed
that, the oral supplementation of 1.5% GTE to TAM-intoxicated rats, exerted an improvement you drink liver tea, injury the tannins againstIfTAM-induced as it have beneficial effects oniron damaged liver cells to in tea inhibit absorption. prevent lipid peroxidation and improve antioxidant enzyme activities. Information on potential synergistic or antagonistic interactions between the constituents of green tea and other chemicals, particularly metals, will lead to a clearer and better understanding of the potential health effects of green tea.
For your spendin g time with me
The aim of this study was to investigate the
possibility of green tea polyphenol, as a novel protective agent for Hepatic injury from chemotherapeutic drug
Herbal medicines derived from plant extracts
are being increasingly utilized to treat a wide variety of clinical disease Protective effects of natural antioxidants against drug-induced toxicities especially whenever free radical generation is involved
Flavonoids are group of polyphenolic
compounds that occur widely in fruit, vegetables, tea, cocoas and red wine
Fresh tea leaves are rich in flavanol
monomers known as catechins such as epicatechins
Epicatechins (antioxidant present in green
tea) scavenge a wide range of free radicals including the most active hydroxyl radical. Epicatechins are effective scavengers of physiologically active reactive oxygen and nitrogen species Epicatechins may chelate metal ions, especially iron and copper
Tamoxifen is prescribed for women with
hormone-receptor-positive breast cancer before and after menopause. Tamoxifen is an anti-estrogen drug that was developed over 30 years ago. It is used widely to treat breast cancer. It is also used to treat a variety of other conditions, including infertility.
Most breast cancers need supplies of the
female hormone estrogen to grow. Cancer cells have sex hormones[estrogen] receptors on their surface called estrogen-receptorpositive (ER-positive) and tamoxifen is most effective against these cancers.
The most common side effects, apart from
nausea, are hot flushes and sweats, particularly at night. Long-term side effects Studies have shown that post-menopausal
women who take tamoxifen over a long period of time may have a very slightly increased risk of developing cancer of the lining of the womb (endometrial cancer).
Animals 1.5% green tea
extract (GTE). This solution was provided to rats as their sole source of drinking water.
Forty adult female
albino rats, weighing 120-170gm were used as experimental animals in this study.
Group 1: Normal control untreated rats. Group 2: TAM -intoxicated rats: Rats were treated
with TAM in a dose of 45 mg/ Kg.day, i.p. , for 7 successive days Group 3: GTE rats: Rats were orally administered 1.5% green tea extract (GTE) as their sole source of drinking water for 18 days. Group 4: TAM-GTE rats: Rats were orally administered 1.5% GTE as their sole source of drinking water 4 days before and 14 days after TAM intoxication (in a dose identical to group 2) as protection against liver injury induced by TAM.
indicator of lipid peroxidatio n
levels of antioxidant enzyme activities
liver damage
Paired t-test was carried out to compare
populations A 0.001 level of probability was used as the criterion for significance.
=gr.3 =gr.4
gr.3 gr.3
gr.4
gr.4
Gr.1
Gr.2
Gr.3
Gr.4
Gr.3
Gr.4 Gr.3 Gr.1
Gr.2 Gr.1
Gr.2 Gr.4
sGPT
sGOT
Gr.1
Gr.2
Gr.3
Gr.4
It was obvious that tamoxifen in toxic doses
lead to oxidative liver damage The oxidation process resulted as a result of TAM-intoxication leads to release of iron ions. These ions, become more reactive in liver. Free irons ions participate in generation of hydroxyl radicals which are the most active reactive oxygen species (ROS) and they react readily with most cellular components
Tamoxifen act here
The levels of antioxidant enzyme
activities in liver homogenates (GST, GPX, SOD and CAT) and GSH were significantly improved upon treatment of TAM-intoxicated rats with 1.5% GTE whereas the level of TBARS were significantly decreased comparable to TAM-intoxicated group.
The destruction and degradation of
phospholipids hydroperoxides are carried out by GPX The decreased GPX level of TAM-intoxicated rats, leads to an increase of toxic level to the cells The decreased activities of GPX and SOD in liver homogenate of TAM-intoxicated rats may be due to oxidative stress induced in activation and/or exhaustion. The decreased GPX activity leads to H2O2 accumulation in the liver which inactivates SOD. SOD GSH plays as protein-bound glutathione and by generation of ascorbate or tocopherol in liver The decreased hepatic GSH in TAM-intoxicated
blocking oxidative damage through lipid peroxidation and protein oxidation, green tea extract
By
can prevent the loss of membrane permeability and dysfunction of cellular proteins and decreases the endogenous level of hydroxyl radical
The data achieved from this study revealed
that, the oral supplementation of 1.5% GTE to TAM-intoxicated rats, exerted an improvement you drink liver tea, injury the tannins againstIfTAM-induced as it have beneficial effects oniron damaged liver cells to in tea inhibit absorption. prevent lipid peroxidation and improve antioxidant enzyme activities. Information on potential synergistic or antagonistic interactions between the constituents of green tea and other chemicals, particularly metals, will lead to a clearer and better understanding of the potential health effects of green tea.
For your spendin g time with me
