Elimination Of Cocaine From Body-galaxy

Pharmacodynamics (What the drugs does to a body)

Drug

Body

Pharmacokinetics (what the body does to a drug) Absorption + Distribution + Metabolism+ Excretion

Routes of administration

Absorption • Moving from the site of administration to the bloodstream – Drugs exert effects by first traveling into the bloodstream

SYSTEMIC CIRCULATION

DRUG

SITE OF ACTION BLOOD

EFFECTS

Distribution • Ability of drug to reach a wide range of tissues -- Lipid solubility (Highly lipid soluble= greater distribution and effect.

Blood-brain barrier limits drug access to brain

Metabolism • Occur mainly in LIVER – some drugs are broken down into other compounds. Some are not transformed at all – Enzymes break down drugs into metabolites

Elimination • a process of the removal of its metabolites from the body

Blood Plasma Absorption & Distribution

Administration Oral, IV, IM, IP, SC, Inhalation, TC

Plasma Protein Binding

Metabolites

Liver

Excretion Intestines, Kidneys, Lungs, etc.

Feces, Urine, Sweat, Saliva

Where is the main sites of drug elimination?

Kidneys

How do kidneys works? • Glomerular filtration • Tubular secretion • Tubular reabsorption

• Drugs are excreted in a variety of ways – Urine – Breath – Feces – Sweat – Saliva

Summary