Drug Interactions

Drugs that significantly inhibit P450 drug metabolism CYP Family 1A2

2C9

Inhibitor Cimetidine Fluoroquinolones Grapefruit juice Macrolides Isoniazid Zileuton Amiodarone Chloramphenicol Cimetidine Isoniazid Metronidazole SSRIs Zafirlokast

2C19

Omeprazole SSRI

2D6

Amiodarone Cimetidine Quinidine SSRI

3A4

Amiodarone Azole antifungals Cimetidine Clarithromycin Cyclosporine Erythromycin Fluorquinolones Grapefruit juice HIV Protease inhibitors MEtronidazooole Quinine SSRI Tacrolimus

Drugs whose Metabolism Inhibited Acetaminophen Clozapine Haloperidol Theophylline TCA Warfarin Barbituates Chloramphenicol Doxorubicin Ibuprofen Phenytoin Chlorpromazine Steroids Tolbutamide S-Warfarin Phenytoin Topiramate R-warfarin Antidepressants Flecainide Lidocaine Mexiletine Opiods Antiarrhythmics Antidepressants Azole antifungals Benzos Calcium channel blockers Cyclosporine Delavirdine Doxorubicin Efavirenze Erythromycin Estrogens HIV protease inhibitors Nafazodone Paclitaxel PPI HMG CoA Red inhibitors Rifabutin Rifampin Sildenafil SSRI Tamoxifen Trazodone Vinca Alkaloids

Drugs that induce P450 mediated drug metabolism CYP Family 1A2

Inducers Benzopyrene Carbamasepine Phenobarbitol Rifampin Omeprazole

2C9

Barbituates (phenobarbitol) Phenytoin Primidone Rifampin

2C19

Carbamazepine Phenobarbitol Phenytoin

2E1

Ethanol Isoniazid

3A4

Barbs Carbamazepine Corticosteroids Efavirenz Phenytoin Rifampin Troglitazone

Drugs whose Metabolism Induced Acetominophen Clozapine Haloperidol Theophylline TCA Warfarin Barbituates Chloramphenicol Doxorubicin Ibuprofen Phenytoin Chlorpromazine Steroids Tolbutamide S-Warfarin TCA Phenytoin Topiramate Warfarin Acetaminophen Ethanol Halothane Antiarrhythmics Antidepressants Azole antifungals Benzos Calcium channel blockers Cyclosporine Delavirdine Doxorubicin Efavirenze Erythromycin Estrogens HIV protease inhibitors Nafazodone Paclitaxel PPI HMG CoA Red inhibitors Rifabutin Rifampin Sildenafil SSRI Tamoxifen Trazodone Vinca Alkaloids