Disorders Of Immunity I

DISORDERS OF IMMUNITY I R. HUGO MARTÍNEZ LOZANO, M.D. Aug-11-2009.

LEARNING OBJECTIVES: K & U GENERAL FEATURES - INNATE & ADAPTIVE - CELLS & TISSUES - MECHANISMS (HLA) DISORDERS OF THE IMMUNE SYSTEM - HYPERSENSITIVITY REACTIONS - TYPES - MECHANISMS - MEDICAL SIGNIFICANCE!!! Ref. pp. 194-217 & lecture’s information 

Cells?

, fungi, leptospira , etc.

TLR-3

Viruses

NK CELLS -Viruses -Neoplasia -Transplant rej.

Cells?

PLASMA CELL Most prominent Organelle?

Cell?

Cell?

CLOSE-UP

TONSILS

TISSUE?

Thymus

???

TISSUE?

TISSUE?

BASOPHIL

HLA COMPLEX

n o f

HLA & RELATED RISK FOR DISEASES

Disease H LAnkylosing spondylitis A Postgonococcal arthritis w Acute anterior uveitis i t Rheumatoid arthritis h Chronic active hepatitis D i Primary Sjögren syndrome s e a sType-1 diabetes e

HLA Allele

Relative Risk

B27

90

B27

14

B27

14

DR4

4

DR3

13

DR3

9

DR3

5

DR4

6

DR3/DR4

20

HYPERSENSITIVITY REACTIONS

HYPERSENSITIVITY REACTIONS TYPE I

Immediate reaction

HYPERSENSITIVITY REACTION I 



LOCAL:- ATOPY – DERMATITIS - RHINITIS - ASTHMA - URTICARIA - GASTROINTESTINAL - ETC. SYSTEMIC: ANAPHYLAXIS

HYPERSENSITIVITY REACTION II

Opsonins (& C)-mediated phagocytosis

HYPERSENSITIVITY REACTION II

Complement (& Fc R)-mediated inflammation

HYPERSENSITIVITY REACTION II

SELECTED EXAMPLES OF H.R.-II      

HEMOLYTIC ANEMIAS GOODPASTURE SYNDROME PEMPHIGUS V. INSULIN-RESISTENT DIABETES MYASTHENIA GRAVIS GRAVES DISESASE

HYDROPS FETALIS

PENPHYGUS VULGARIS

HYPERSENSITIVITY REACTIONS III SOME EXAMPLES

L.E… Skin

REYNAUD’S PHENOMENON

HYPERSENSITIVITY REACTION IV 

TYPES: - DELAYED (GRANULOMA) - T-CELL MEDIATED CYTOTOXICITY

HYPERSENSITIVITY REACTION IV

TB

Tuberculous granuloma

QUESTIONS?