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Dipti Chourasia [email protected]

Current address Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGIMS) Lucknow (U.P.) 226014, India Alternate e-mail: [email protected] Phone: (Lab.) +91-522-2668700, Ext. 2399, 2420 (M) +91-9839302647 Education Pursuing (2005-till date)

Ph.D. (Submitted thesis on July 23rd, 2009) Sanjay Gandhi Postgraduate Institute of Medical Sciences Lucknow, India

2003

M.Sc. in Life Sciences Devi Ahilya University, Indore, India

2001

B.Sc. (Biology) Zoology, Botany, Chemistry Vikram University, Ujjain, India

Areas of research in interest: Applied Molecular Biology, Genetics Awards and Honors •



• •

International Travel grant from Department of Science and Technology, Govt. of India, New Delhi for attending 1st Biennial Congress on Asian Neurogastroenterology and Motility Association at Seoul, South Korea in April 2009. Young Investigator Award for presenting paper “Genotypic and functional role of IL-1B and IL-1RN on risk of gastroesophageal reflux disease (GERD): Presence of IL-1B511*T/IL-1RN*1 (T1) haplotypes may protect against the disease”, at ANMA-2009 held at Seoul (South Korea), April 02nd-04th, 2009. Qualified Indian Council of Medical Research (ICMR)-Junior Research Fellowship (JRF) examination (July 2003). Qualified Council of Scientific and Industrial Research (CSIR)-University Grant Commission (UGC) joint entrance National Eligibility Test (NET) for Lecturership (December 2002).

Membership of academic societies •

Member of Genome Foundation, Hyderabad, India

Research Experience(s)/ Training(s) 1. Pursuing Ph.D. in Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India from June 27, 2005 to till date on “Gastro-

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esophageal Reflux Disease and Helicobacter pylori: Possible role of IL-1β, IL-8 and ERK in gastric mucosal injury altering severity of the disease”. Submitted thesis on July 23rd, 2009. 2. Worked as ICMR-JRF in Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India from April 20-June 26, 2005. 3. Worked as ICMR-JRF in Molecular Reproduction Unit, Rajiv Gandhi Centre for Biotechnology, Thiruvnanthapuram, India from April 15, 2004 to March 09, 2005. 4. Worked as Junior Research Fellow in Molecular Reproduction Unit, Devi Ahilya University, Indore, India from January 20, 2004 to April 15, 2004 under DST sponsored project entitled “Characterization of the components of the mice NADPH oxidase of the ovary and the uterus expressed during early pregnancy”. 5. Six months M.Sc. Dissertation on “Development of molecular tools to study the cross talk between MAP kinase kinase-1 and Cyclin dependent kinase 5” from Eukaryotic Gene Expression Lab, National Institute of Immunology (NII), New Delhi, India w.e.f. January 13, 2003 to June 30, 2003. 6. One Month Summer Training at Quality control department, Ipca Laboratories Limited, Ratlam, India w.e.f. June 04, 2002 to July 06, 2002. Publications 1. Chourasia D, Achyut BR, Tripathi S, Mittal B, Mittal RD, Ghoshal UC (2009). Genotypic and functional role of IL-1B and IL-1RN on risk of Gastroesophageal reflux disease (GERD): presence of IL-1B-511*T/IL-1RN*1 (T1) haplotype may protect against the disease. American Journal of Gastroenterology, advance online published on July 14th, 2009. DOI: 10.1038/ajg.2009.382 2. Ghoshal UC, Chourasia D, Tripathi S, Misra A, Singh K (2008). Relationship of severity of gastroesophageal reflux disease with gastric acid secretory profile and esophageal acid exposure during nocturnal acid breakthrough: A study using 24-h dual-channel pH-metry. Scandinavian Journal of Gastroenterology 43(6): 654-61. 3. Chourasia D, Ghoshal UC (2008). Pathogenesis of gastro-oesophageal reflux disease: what role do Helicobacter pylori and host genetic factors play? Tropical Gastroenterology 29(1): 13-9. 4. Tripathi S, Ghoshal U, Ghoshal UC, Mittal B, Krishnani N, Chourasia D, Agarwal AK, Singh K (2008). Gastric carcinogenesis: Possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes. Scandinavian Journal of Gastroenterology 43(4): 431-9. 5. Chourasia D, Misra A, Pandey R, Ghoshal UC (2008). Gastric atrophy and intestinal metaplasia in a patient on long-term proton pump inhibitor therapy. Tropical Gastroenterology 29 (3): 172-174. 6. Ghoshal UC, Kumar S, Chourasia D, Misra A (2009). Lactose hydrogen breath test versus lactose tolerance test in the tropics: Does positive lactose tolerance test reflect more severe lactose malabsorption? Accepted in Tropical Gastroenterology.

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7. Ghoshal UC, Tripathi S, Chourasia D (2007). Principle of statistical analysis in clinical research: A primer. In Mehta R. Clinical Gastroenterology, Paras Publishing, Hyderabad, India. Chapter 49, pp 372-386 (Book chapter). Communicated papers: 8. Chourasia D, Misra A, Tripathi S, Krishnani N, Ghoshal UC. Patients with H. pylori infection have less severe gastroesophageal reflux disease (GERD): A study using endoscopy, 24-hour gastric and esophageal pH metry. (Communicated in Digestive Diseases and Sciences). 9. Misra A, Chourasia D, Ghoshal UC. Manometric and symptomatic spectrum of motor dysphagia in a tertiary referral center in northern India. (Communicated in Indian Journal of Gastroenterology on 10.04.2009, Manuscript no. IJOG-D-09-00076). 10. Tripathi S, Ghoshal U, Mittal B, Chourasia D, Kumar S, Ghoshal UC. Glutathione-Stransferase enzyme activity and Helicobacter pylori: Does association with GST polymorphisms explain the Indian enigma of gastric cancer? (Communicated in Journal of Medical Microbiology on 10.06.2009, Manuscript no. JMM/2009/013482)

Seminar(s)/ Workshop(s)/ Symposium Attended 1. First Biennial Congress on “Asian Neurogastroenterology and Motility Association (ANMA2009)” held at Seoul, South Korea from April 2nd-4th, 2009. 2. “Asia Pacific Digestive Week 2008” held at New Delhi, India, September 13th-16th, 2008. 3. Conference on “Health Promotion” held at Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, September 02, 2007. 4. Mid Term Conference of The Indian Society of Gastroenterology “Theme: Dilemmas in Clinical Practice and Preventive Gastroenterology: Stepping outside the Clinics” held at Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, September 01st-02nd, 2007. 5. CME on “Molecular Techniques for the Diagnosos of Parasitic Diseases” and Workshop on “Transfer of Basic Technology to Rural Areas” held at Department of Parasitology, Postgraduate Institute of Medical Education and Research, Chandigarh, India, March 15th17th, 2007. 6. 4th SR Naik Memorial Workshop on “Biomedical Research: Methods, Tools & Future” held at Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, September 23rd-24th, 2006.

7. 3rd SR Naik Memorial Workshop on “Computers in Biomedical Sciences” held at Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India, September 10th-11th, 2005.

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8. National Seminar on “Bioinformatics” held at Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India, December 14th-16th, 2004. 9. International Symposium on “Steriod Hormone Receptor Superfamily & Molecular Signaling” held at Rajiv Gandhi Centre for Biotechnology, Thiruvananthapuram, India, November 25th-27th, 2004. 10. Workshop on “Genomics/Proteomics” held at School of Biotechnology, Devi Ahilya University, Indore, India, January 11th-12th, 2002. Abstract/Paper(s) presented at National/International conferences 1. Chourasia D, Achyut BR, Tripathi S, Mittal B, Mittal RD, Ghoshal UC. Genotypic and functional role of IL-1B and IL-1RN on risk of gastroesophageal reflux disease (GERD): Presence of IL-1B-511*T/IL-1RN*1 (T1) haplotypes may protect against the disease held at Seoul (South Korea), April 02nd-04th, 2009. (Oral Presentation, Young Investigator Awardee) 2. Chourasia D, Misra A, Tripathi S, Krishnani N, Ghoshal UC. Patient with H. pylori infection have less severe gastroesophageal reflux disease (GERD): A study using 24-hour dualchannel ph metry. The 1st Biennial Congress of the Asian Neurogastroenterology and Motility Association held at Seoul (South Korea), April 02nd-04th, 2009. (Poster) 3. Chourasia D, Tripathi S, Krishnani N, Ghoshal UC. Increase in gastric mucosal IL-8 levels among IL-8-251 A/T genotypes leads to reduced severity of gastroesophageal reflux disease held at Seoul (South Korea), April 02nd-04th, 2009. (Poster) 4. Chourasia D, Misra A, Tripathi S, Krishnani N, Ghoshal UC. Endoscopic, 24-h gastric and esophageal acid profile in patients with GERD: Do patients with H. pylori infection have less severe GERD? Asia Pacific Digestive Week 2008 held at New Delhi, India, September 13th16th, 2008. (Oral Presentation) 5. Chourasia D, Achyut BR, Mittal B, Tripathi S, Mittal RD, Ghoshal UC. Genetic factor in pathogenesis of GERD: IL1B-511T/IL1RN*1 haplotype may protect against the disease” Asia Pacific Digestive Week 2008 held at New Delhi, India, September 13th-16th, 2008. (Plenary session presentation) 6. Misra A, Chourasia D, Ghoshal UC. Manometric and symptomatic spectrum of motor dysphagia in a tertiary referral centre in northern India. Asia Pacific Digestive Week 2008 held at New Delhi, India, September 13th-16th, 2008. (Poster) 7. Tripathi S, Ghoshal U, Mittal B, Chourasia D, Kumar S, Ghoshal UC. Role of Toll-like receptor Thr 399 Ileu polymorphism in gastric carcinogenesis. Asia Pacific Digestive Week 2008 held at New Delhi, India, September 13th-16th, 2008. (Poster) 8. Tripathi S, Ghoshal U, Mittal B, Chourasia D, Kumar S, Ghoshal UC. Glutathione-Stransferase enzyme activity and Helicobacter pylori: does association with GST polymorphisms explain the India enigma of gastric cancer? Asia Pacific Digestive Week 2008 held at New Delhi, India, September 13th-16th, 2008. (Poster)

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9. Tripathi S, Ghoshal U, Mittal B, Chourasia D, Kumar S, Ghoshal UC. Role of microsomal epoxide hydrolase exon 4 polymorphism and Helicobacter pylori in gastric carcinogenesis. Asia Pacific Digestive Week 2008 held at New Delhi, India, September 13th-16th, 2008. (Poster) 10. Misra A, Chourasia D, Ghoshal UC. Manometry spectrum of motor dysphagia in a tertiary referral centre in northern India. XIX Annual Conference of the Uttar Pradesh Chapter of India Society of Gastroenterology held at GSVM Medical College, Kanpur, India, March 15th-16th, 2008. (Poster) 11. Chourasia D, Achyut BR, Tripathi S, Mittal B, Mittal RD, Ghoshal UC. Genetic factor in pathogenesis of Gastroesophageal reflux disease: IL1B-511T/IL1RN*1 haplotype may protect against the disease. XIX Annual Conference of the Uttar Pradesh Chapter of Indian Society of Gastroenterology held at GSVM Medical College, Kanpur, India, March 15th-16th, 2008. (Third prize in Oral Presentation) 12. Chourasia D, Misra A, Ghoshal UC. Validation of Carlsson Dent Questionnaire for evaluation of patients with gastroesophageal reflux disease in India. 48th Annual Conference of Indian Society of Gastroenterology held at Bengaluru, India, November 15th18th, 2007. (Poster) 13. Chourasia D, Achyut B R, Tripathi S, Mittal B, Ghoshal UC. Genetic factor in pathogenesis of gastroesophageal reflux disease: IL1B-511 T allele may protect against disease. 48th Annual Conference of Indian Society of Gastroenterology held at Bengaluru, India, November 15th-18th, 2007. (Poster) 14. Ghoshal UC, Kumar S, Chourasia D, Misra A. Lactose hydrogen breath test versus lactose tolerance test in the tropics: Does positive LTT reflect more severe lactose maldigestion? 48th Annual Conference of Indian Society of Gastroenterology held at Bengaluru, India, November 15th-18th, 2007. (Poster) 15. Ghoshal UC, Chourasia D, Tripathi S, Misra A, Singh K. Relationship of severity of gastroesophageal reflux disease with gastric acid secretory profile and esophageal acid exposure during nocturnal acid breakthrough: a study using 24-h dual channel pH-metry. 48th Annual Conference of Indian Society of Gastroenterology held at Bengaluru, India, November 15th-18th, 2007. (Poster) 16. Chourasia D, Misra A, Ghoshal UC. Validation of Carlsson Dent Questionnaire in patients with gastroesophageal reflux disease in India. 18th Annual Conference of U.P. Chapter of Indian Society of Gastroenterology held at Bareilly, India, May 12th-13th, 2007. (Second prize in free oral paper session)

17. Chourasia D, Misra A, Pandey R, Ghoshal UC. Long term proton pump inhibitor induced gastric atrophy and intestinal metaplasia: a case report. 47th Annual Conference of Indian Society of Gastroenterology held at Mumbai, India, November 8th-12th, 2006. (Poster)

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References

:

Present Engagement

Dr. Uday C Ghoshal Associate Professor Department of Gastroenterology S.G.P.G.I.M.S. Lucknow (U.P.) 226 014 Phone: +91-522-2668700 ext (O) 2405, (R) 2406 E-mail: [email protected]

:

Dr. R D Mittal Additional Professor Department of Urology (Biochemistry) S.G.P.G.I.M.S. Lucknow (U.P.) 226 014 Phone: +91-522-2668700 ext (O) 2116 E-mail: [email protected]

:

Dr. Balraj Mittal Professor Department of Genetics S.G.P.G.I.M.S. Lucknow (U.P.) 226 014 Phone: +91-522-2668700 ext (O) 2322, (R) 2323 E-mail: [email protected]

:

Dr. Narendra Krishnani Additional Professor Department of Pathology S.G.P.G.I.M.S. Lucknow (U.P.) 226 014 Phone: +91-522-2668700 ext (O) 2946 E-mail: [email protected] :

Ph.D. Student (thesis submitted) Supervisor: - Dr. Uday C Ghoshal Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India

I hereby declare that the above mentioned information is true to my knowledge.

Place: Lucknow

(Dipti Chourasia)

nd

Date: August 2 , 2009

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