Delhi Ucsf Jun2009
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HST - in summary: InterConnected Philosophy…
Education & Research
BEHNEBBJI Magnet RLEHBS CBELab BiologyLEES Math DEAS Sloan NE SPL OBL CIMIT AI Lab MGH CEM EECS SPL HSDMBCS Media Lab Steel Lab Whitehead ME LCSAA Mol. Med.
Physics MSE Neuroscience ChE Biophysics MTL
Practice
Equal Footing: Multidisciplinary
Multicultural/ Multiprofessional: Bench to Bedside
Extensive Root System: Capitalize on Environment
REGIONAL CENTRE FOR BIOTECHNOLOGY Faridabad, National Capital Region INDIA
Autonomous Institution under the aegis of
Department of Biotechnology, Government of India & UNESCO
Why UNESCO Connectivity and a Regional Emphasis? The Needham paradox: Although developing societies/economies traditionally use empirical technologies for social betterment, they face critical gaps in connecting science with technology innovations of local utility Thus, a diversity of locally driven perspectives on one hand, and excellence of global standards on the other would be essential in order to generate competitive human resource for the developing world
Unique CoCo-location
CONSTITUENCIES Students
Industry
Patients
RCB
THSTI
CHC
Academic
Translational
Clinical
Tech Platforms
Animal facilities Prog 1 Prog 2 Prog 3 Domain-specific centres
Domain-specific centres
Domain-specific centres
Health Biotech Science Cluster CLUSTER BOARD
Prog 4
Unique Niche Interdisciplinary education and research Engineering
Physics
Health Biotechnology
Medicine
Chemistry
Mandate to provide a platform for interdisciplinary research and education in order to create human resources required at the biotech interface of engineering, chemistry, physics and medicine. to empower human resources critical for a wide range of biotech needs and to seek knowledge-based innovative and context-specific biotech solutions
Objectives • To promote capacity building through education, research & development in biotechnology • To aim for sustainable development through regional and international cooperation • To execute education and expertise building activities to generate knowledge in biotechnology • To facilitate transfer of knowledge relating to biotechnology at the regional level • To create a hub of biotechnology expertise in the immediate region with global networking. • To undertake research, development and scientific investigations in collaboration with other relevant research centres in the region and beyond • To organize scientific symposia & conferences and to conduct expertise building workshops in contemporary areas of Biotechnology • To disseminate the outcomes of research activities through international publications and generation of intellectual property • Promote collaborative research and development networking programmes in specific areas of biotechnology • To create network of satellite centres in the region
Faculty • Regular Faculty - a framework for faculty recruitment is being worked out in order seek out the best
• Adjunct Faculty - from cluster and partner institutions within NCR
• Visiting Professorship - Offer five-year lab-visiting professorships
• Re-entry Grant - for Indian scientists working abroad
• Young Investigator Awards - for outstanding post-doctoral Fellows
Immediate major areas of research These are only indicative and not restrictive
• Systems Biology & Rational Drug Design ─ Analyses of complex diseases for identification of intervention points ─ Development of knowledge-based drug discovery approaches
• Regenerative Medicine & Tissue Engineering ─ Application of novel engineering and material science approaches to understanding and building tissue architecture
• Nanoscience for Biotechnology ─ Design of novel nanodevices for biosensing, diagnostic and therapeutic utility
Educational approaches Regional participation
• Interdisciplinary doctoral programmes ─ Integrated programs through participation of domainspecific networked centres and in RCB groups as they develop
• Special-domain workshops & post-graduate programmes ─ Intensive short-term workshops with global faculty and structured postgraduate progammes
Regional Centre for Biotechnology A University of Higher Education and Research in Biotechnology With active contributions from the institutions within the Cluster/vicinity and from the larger world providing a meeting place where innovation, enterprise, and industrial development will germinate.
Vaccine and Infectious Disease Research Center (VIDRC) at Translational Health Science and Technology Institute (THSTI)
Vision To improve human health through research directed at the prevention, intervention, and therapy for infectious diseases that pose a serious threat to humanity
Mission To study infectious diseases and pathogens to generate translatable knowledge for developing prophylactic and therapeutic measures against diseases prevalent in India
Aims and Objectives In pursuit of its mission, the VIDRC will:
Conduct a comprehensive research program spanning basic through translational research,
Serve as a national resource for biomedical researchers by providing access to qualified scientists,
Establish partnerships with industry and academia
Develop national and international collaborations, and
Serve as a center of excellence for training future researchers in the fields of science and technology relevant to the vaccine and infectious disease research
Vaccine Research at VIDRC Identify virulence properties of the pathogens through studies of molecular pathogenesis to construct vaccine candidates and their pre-clinical evaluation. Develop of novel vaccine delivery systems including recombinant viral vectors.
Assess the suitability of candidate vaccines in clinical studies. Measure human immune responses to vaccines. Evaluate the efficacy of candidate vaccines in large-scale field trials. Advise governments and health management agencies on vaccine policy.
Infectious Disease Research at VIDRC Strengthen basic and applied research on the pathogen, host and environmental factors that influence disease emergence Use knowledge of pathogen, host, and environment interactions to enhance our ability to predict and prevent conditions that lead to human disease Support sequencing and post-genomics research of emerging infectious disease agents and animal vectors to reveal genetic basis for pathogen evolution, adaptation, and pathogenicity Develop new strategies to control diseases that are re-emerging due to drug or insecticide resistance and identify better control strategies for intractable infectious diseases that continue to challenge global health Maintain and develop the scientific expertise required to respond to future health threats by supporting research and training programs
Functioning of VIDRC NII / ICGEB DUSC Pathogen & Disease biology studies
WHO CDC
PATH
Establish partnerships with international vaccine R&D institutions and funding sources
NIH
New adjuvants and vector development
VIDRC cGLP, cGMP and BSL3 facility for DBT
Vaccine antigen discovery
Clinical Trials
SAS
NDSA
Clinical development of vaccines through various stages and data management, vaccine need forecasting, market evaluation, policy advice, IP evaluation and protection
Key activities
Ø Basic Research (Lab, patient or population based) Ø Translational biology, Bioprocess, formulation and Analytical research Ø Clinical development through Phase-I, II and III (SAS and NDSA) Ø Population based studies on IDs (SAS, NDSA, other partners) Ø Project management (SAS, NDSA) Ø Licensing and Business development
Scientific activities of VIDRC Toxicology
QC assays
Vector Development
Adjuvant Research
Vaccine Delivery
Microbiology
Pre-clinical Development
Vaccine Release Tests
Process Development
Protocol Development and approval
Clinical Trial
Candidate Vaccine For Further improvement
Data storage and analysis Efficacy Assays and validation
Immunology
Surveillance
Volunteer recruitment and trial monitoring
Infectious Disease Research
Biomarkers
VIDRC activity Cohorts
SAS activity
Scientific program of VIDRC (ongoing research activities) Oral Rotavirus vaccine 116E clinical development program Completed phase II trial in children Interference trial with EPI vaccines to be taken up shortly Disease burden and RV genotype prevalence studies planned Phase III efficacy trial of vaccine under planning Tuberculosis vaccine development program rBCG expressing 85C and other antigens developed Recombinants show enhanced protective efficacy in animals than BCG Constructs to be humanized for phase I trial Japanese encephalitis vaccine development program Process for a tissue culture derived JE vaccine transferred to industry where it has been scaled up rAd5 expressing novel JEV antigen provides robust protection in animal studies Exploring ovine adenovirus based delivery of JEV antigen Developing infectious clone of JEV to generate attenuated viruses Development of novel viral vectors for antigen delivery Novel adenoviruses from animals (fowl and buffalos) being isolated These will be characterized genetically and developed as vectors for antigen delivery
New Research Activities of VIDRC ???? Hepatitis E Vaccine development Why Neutralizing abs decline faster? Immune responses in pregnant women (why high mortality?) Noroviruses Very little data on virus activity in India, strains, genotypes, incidence?? Vaccine development Leishmania, Pneumococcal and Typhoid vaccines Vaccine development using genome-based approach and bioinformatics?? Cancer vaccines HPV, breast/oral cancers Research on antivirals (RCB will have a strong drug development program) Development of inhibitors for protease, replicase, helicase (Structure based modeling) Novel adjuvants and viral vectors Influenza, HIV, Dengue
Education & Research
BEHNEBBJI Magnet RLEHBS CBELab BiologyLEES Math DEAS Sloan NE SPL OBL CIMIT AI Lab MGH CEM EECS SPL HSDMBCS Media Lab Steel Lab Whitehead ME LCSAA Mol. Med.
Physics MSE Neuroscience ChE Biophysics MTL
Practice
Equal Footing: Multidisciplinary
Multicultural/ Multiprofessional: Bench to Bedside
Extensive Root System: Capitalize on Environment
REGIONAL CENTRE FOR BIOTECHNOLOGY Faridabad, National Capital Region INDIA
Autonomous Institution under the aegis of
Department of Biotechnology, Government of India & UNESCO
Why UNESCO Connectivity and a Regional Emphasis? The Needham paradox: Although developing societies/economies traditionally use empirical technologies for social betterment, they face critical gaps in connecting science with technology innovations of local utility Thus, a diversity of locally driven perspectives on one hand, and excellence of global standards on the other would be essential in order to generate competitive human resource for the developing world
Unique CoCo-location
CONSTITUENCIES Students
Industry
Patients
RCB
THSTI
CHC
Academic
Translational
Clinical
Tech Platforms
Animal facilities Prog 1 Prog 2 Prog 3 Domain-specific centres
Domain-specific centres
Domain-specific centres
Health Biotech Science Cluster CLUSTER BOARD
Prog 4
Unique Niche Interdisciplinary education and research Engineering
Physics
Health Biotechnology
Medicine
Chemistry
Mandate to provide a platform for interdisciplinary research and education in order to create human resources required at the biotech interface of engineering, chemistry, physics and medicine. to empower human resources critical for a wide range of biotech needs and to seek knowledge-based innovative and context-specific biotech solutions
Objectives • To promote capacity building through education, research & development in biotechnology • To aim for sustainable development through regional and international cooperation • To execute education and expertise building activities to generate knowledge in biotechnology • To facilitate transfer of knowledge relating to biotechnology at the regional level • To create a hub of biotechnology expertise in the immediate region with global networking. • To undertake research, development and scientific investigations in collaboration with other relevant research centres in the region and beyond • To organize scientific symposia & conferences and to conduct expertise building workshops in contemporary areas of Biotechnology • To disseminate the outcomes of research activities through international publications and generation of intellectual property • Promote collaborative research and development networking programmes in specific areas of biotechnology • To create network of satellite centres in the region
Faculty • Regular Faculty - a framework for faculty recruitment is being worked out in order seek out the best
• Adjunct Faculty - from cluster and partner institutions within NCR
• Visiting Professorship - Offer five-year lab-visiting professorships
• Re-entry Grant - for Indian scientists working abroad
• Young Investigator Awards - for outstanding post-doctoral Fellows
Immediate major areas of research These are only indicative and not restrictive
• Systems Biology & Rational Drug Design ─ Analyses of complex diseases for identification of intervention points ─ Development of knowledge-based drug discovery approaches
• Regenerative Medicine & Tissue Engineering ─ Application of novel engineering and material science approaches to understanding and building tissue architecture
• Nanoscience for Biotechnology ─ Design of novel nanodevices for biosensing, diagnostic and therapeutic utility
Educational approaches Regional participation
• Interdisciplinary doctoral programmes ─ Integrated programs through participation of domainspecific networked centres and in RCB groups as they develop
• Special-domain workshops & post-graduate programmes ─ Intensive short-term workshops with global faculty and structured postgraduate progammes
Regional Centre for Biotechnology A University of Higher Education and Research in Biotechnology With active contributions from the institutions within the Cluster/vicinity and from the larger world providing a meeting place where innovation, enterprise, and industrial development will germinate.
Vaccine and Infectious Disease Research Center (VIDRC) at Translational Health Science and Technology Institute (THSTI)
Vision To improve human health through research directed at the prevention, intervention, and therapy for infectious diseases that pose a serious threat to humanity
Mission To study infectious diseases and pathogens to generate translatable knowledge for developing prophylactic and therapeutic measures against diseases prevalent in India
Aims and Objectives In pursuit of its mission, the VIDRC will:
Conduct a comprehensive research program spanning basic through translational research,
Serve as a national resource for biomedical researchers by providing access to qualified scientists,
Establish partnerships with industry and academia
Develop national and international collaborations, and
Serve as a center of excellence for training future researchers in the fields of science and technology relevant to the vaccine and infectious disease research
Vaccine Research at VIDRC Identify virulence properties of the pathogens through studies of molecular pathogenesis to construct vaccine candidates and their pre-clinical evaluation. Develop of novel vaccine delivery systems including recombinant viral vectors.
Assess the suitability of candidate vaccines in clinical studies. Measure human immune responses to vaccines. Evaluate the efficacy of candidate vaccines in large-scale field trials. Advise governments and health management agencies on vaccine policy.
Infectious Disease Research at VIDRC Strengthen basic and applied research on the pathogen, host and environmental factors that influence disease emergence Use knowledge of pathogen, host, and environment interactions to enhance our ability to predict and prevent conditions that lead to human disease Support sequencing and post-genomics research of emerging infectious disease agents and animal vectors to reveal genetic basis for pathogen evolution, adaptation, and pathogenicity Develop new strategies to control diseases that are re-emerging due to drug or insecticide resistance and identify better control strategies for intractable infectious diseases that continue to challenge global health Maintain and develop the scientific expertise required to respond to future health threats by supporting research and training programs
Functioning of VIDRC NII / ICGEB DUSC Pathogen & Disease biology studies
WHO CDC
PATH
Establish partnerships with international vaccine R&D institutions and funding sources
NIH
New adjuvants and vector development
VIDRC cGLP, cGMP and BSL3 facility for DBT
Vaccine antigen discovery
Clinical Trials
SAS
NDSA
Clinical development of vaccines through various stages and data management, vaccine need forecasting, market evaluation, policy advice, IP evaluation and protection
Key activities
Ø Basic Research (Lab, patient or population based) Ø Translational biology, Bioprocess, formulation and Analytical research Ø Clinical development through Phase-I, II and III (SAS and NDSA) Ø Population based studies on IDs (SAS, NDSA, other partners) Ø Project management (SAS, NDSA) Ø Licensing and Business development
Scientific activities of VIDRC Toxicology
QC assays
Vector Development
Adjuvant Research
Vaccine Delivery
Microbiology
Pre-clinical Development
Vaccine Release Tests
Process Development
Protocol Development and approval
Clinical Trial
Candidate Vaccine For Further improvement
Data storage and analysis Efficacy Assays and validation
Immunology
Surveillance
Volunteer recruitment and trial monitoring
Infectious Disease Research
Biomarkers
VIDRC activity Cohorts
SAS activity
Scientific program of VIDRC (ongoing research activities) Oral Rotavirus vaccine 116E clinical development program Completed phase II trial in children Interference trial with EPI vaccines to be taken up shortly Disease burden and RV genotype prevalence studies planned Phase III efficacy trial of vaccine under planning Tuberculosis vaccine development program rBCG expressing 85C and other antigens developed Recombinants show enhanced protective efficacy in animals than BCG Constructs to be humanized for phase I trial Japanese encephalitis vaccine development program Process for a tissue culture derived JE vaccine transferred to industry where it has been scaled up rAd5 expressing novel JEV antigen provides robust protection in animal studies Exploring ovine adenovirus based delivery of JEV antigen Developing infectious clone of JEV to generate attenuated viruses Development of novel viral vectors for antigen delivery Novel adenoviruses from animals (fowl and buffalos) being isolated These will be characterized genetically and developed as vectors for antigen delivery
New Research Activities of VIDRC ???? Hepatitis E Vaccine development Why Neutralizing abs decline faster? Immune responses in pregnant women (why high mortality?) Noroviruses Very little data on virus activity in India, strains, genotypes, incidence?? Vaccine development Leishmania, Pneumococcal and Typhoid vaccines Vaccine development using genome-based approach and bioinformatics?? Cancer vaccines HPV, breast/oral cancers Research on antivirals (RCB will have a strong drug development program) Development of inhibitors for protease, replicase, helicase (Structure based modeling) Novel adjuvants and viral vectors Influenza, HIV, Dengue
