Cullen's Sign
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Cullen's sign is blue-black bruising of the area around the umbilicus. It is named for Thomas S. Cullen (1869-1953),[1] who was an obstetrician and first described the sign in ruptured ectopic pregnancy in 1916.[2] This sign takes 24-48 hours to appear and predicts a severe attack of acute pancreatitis, with mortality rising from 8-10% to 40%. It may be accompanied by Grey Turner's sign[3] (bruising of the flank), which may then be indicative of Pancreatic necrosis with retroperitoneal or intraabdominal bleeding.
Causes Causes include: • • • •
acute pancreatitis, where methaemalbumin formed from digested blood tracks around the abdomen from the inflamed pancreas bleeding from blunt abdominal trauma bleeding from ruptured abdominal aortic aneurysm bleeding from ruptured ectopic pregnancy
Causes Causes include: • • • •
acute pancreatitis, where methaemalbumin formed from digested blood tracks around the abdomen from the inflamed pancreas bleeding from blunt abdominal trauma bleeding from ruptured abdominal aortic aneurysm bleeding from ruptured ectopic pregnancy
