Clinically Significant Pituitary Tumors Secrete This Excess

You’re invited The Second Annual Seattle Pituitary Symposium

A discussion with leaders in pituitary management

A Patient’s Road map to the World of

CUSHING’S SYNDROME Saturday, May 9, 2009 Seattle Pituitary Center Swedish Neuroscience Institute Swedish Medical Center/Cherry Hill 550 17th Ave. Seattle, Washington

Experts from around the world will lead a day-long educational seminar and discussions focusing on Cushing’s syndrome.

Background Information on Cushing’s Cushing’s syndrome is a hormonal disorder caused by prolonged exposure to high levels of cortisol on the body’s tissues. Also known as hypercortisolism, Cushing’s syndrome is somewhat rare and most commonly affects adults aged 20 to 50. Cushing’s disease is a form of Cushing’s syndrome, caused by a hormone-secreting pituitary tumor. About 10 percent of clinically significant pituitary tumors secrete this excess hormone. This elevated hormone level in turn stimulates the adrenal glands to produce excess cortisol. This disease process is called Cushing’s disease, named after the famous neurosurgeon, Harvey Cushing.

Agenda 8:15 a.m. 9:10 a.m. 9:20 a.m. 10 a.m. 10:40 a.m. 11 a.m. 11:40 a.m. 12:20 p.m. 1:10 p.m. 2:10 p.m. 2:50 p.m. 3:30 p.m. 3:50 p.m. 4:30 p.m. 5:10 p.m.

Registration Begins/Continental Breakfast Welcome William H. Ludlam, M.D., Ph.D. Introduction and Overview of Endogenous Cushing’s Syndrome Roberto Salvatori, M.D. Medical Treatment of Hypercortisolemia: Pasireotide (SOM 230), Mifepristone and Other Pharmacologic Agents William H. Ludlam, M.D., Ph.D. Break Quality of Life in Patients with Cushing’s Syndrome Mary Lee Vance, M.D. Cyclic Cushing’s Disease: Is it a Rare Variant or an Important Clinical Consideration? A. Brew Atkinson, DSC, M.D. Lunch Patient Small Group Discussions Stereotactic Radiosurgery in the Treatment of Cushing’s Disease Jason P. Sheehan, M.D., Ph.D. Advances in the Surgical Treatment of ACTH-producing Pituitary Adenomas Marc R. Mayberg, M.D. Break A Physiological Approach to the Diagnosis and Differential Diagnosis of Cushing’s Hershel Raff, Ph.D. Post-Operative Evaluation and Management of the Patient with Cushing’s Syndrome Lewis S. Blevins Jr., M.D. Acknowledgments and Closing Comments William H. Ludlam, M.D., Ph.D.

About the Presenters A. Brew Atkinson, DSC, M.D. Senior Consultant Endocrinologist, Regional Centre for Endocrinology and Diabetes, Royal Victoria Hospital Professor of Endocrinology, Queen’s University Belfast, Northern Ireland, United Kingdom Lewis S. Blevins Jr., M.D. Professor of Clinical Medicine and Clinical Neurological Surgery Medical Director, California Center for Pituitary Disorders at UCSF San Francisco, California William H. Ludlam, M.D., Ph.D. Director, Seattle Pituitary Center Swedish Neuroscience Institute Seattle, Washington Marc R. Mayberg, M.D. Co-Director, Swedish Neuroscience Institute Seattle, Washington Hershel Raff, Ph.D. Professor of Medicine, Medical College of Wisconsin Director, Endocrine Research, Aurora St. Luke’s Medical Center Milwaukee, Wisconsin Roberto Salvatori, M.D. Director, Johns Hopkins Pituitary Tumor Center Associate Professor of Medicine, Division of Endocrinology Johns Hopkins University School of Medicine Baltimore, Maryland Jason P. Sheehan, M.D., Ph.D. Co-Director of the Gamma Knife Center Department of Neurological Surgery and Radiation Oncology University of Virginia Charlottesville, Virginia Mary Lee Vance, M.D. Professor of Internal Medicine and Neurosurgery Associate Director, General Clinical Research Center, University of Virginia, Charlottesville, Virginia

Location/Parking/Directions The patient conference will be held at the Swedish Education and Conference Center, on the first floor of the James Tower at Swedish Medical Center/Cherry Hill, 550 17th Avenue, Seattle, Washington. From the North, traveling south on I-5: Take I-5 southbound to the James Street exit (exit 165 A). Turn left (east) on James (note: James will become Cherry Street). Travel east on Cherry five blocks to the intersection of Cherry and 16th Avenue. Turn right onto 16th Avenue, turn right into the parking garage. Take the elevator to the skybridge and follow the signs to the Swedish Education and Conference Center located in the James Tower. From the South, traveling north on I-5: Take I-5 northbound to the James Street exit (exit 164 A). Turn right (east) onto James (note: James will become Cherry Street). Travel east on Cherry five blocks to the intersection of Cherry and 16th Avenue. Turn right onto 16th Avenue, turn right into the parking garage. Take the elevator to the skybridge and follow the signs to the Swedish Education and Conference Center located in the James Tower. Additional parking (for a slightly higher fee) is also available underneath the main hospital entrance on Jefferson Street between 16th and 18th Ave. Enter the main lobby and follow the signs to the conference.

Registration Information Register online! To register for the Seattle Pituitary Symposium, visit www.swedish. org/neuroscience and click on “Classes” or call 206-386-2502 for more information. The fee is $50 per person (includes breakfast, lunch and snacks; scholarships available).