Cervical Cancer Final.pptx

CERVICAL CANCER

• ASHISH S.BHILANGE

• TASMIYA KAUSAR

SK.

INTRODUCTION According to National Cancer Institute Cervical cancer is the cancer that forms in the tissues of the cervix. It is the malignant tumor of the cervix,the lowermost part of the uterus.

ETIOLOGY • Primary underlying cause of cervical cancer is the

infection with Human Papilloma Virus ,mostly due to sexual contact. • It usually takes 10-20 years from precursor lesion caused by HPV to develop into invasive cancer. • It produces an array of infections ranging from benign warts to malignant neoplasia of cervix.

WHAT IS HPV? • Human papilloma virus belongs the family

Papillomaviridae. • It has selective tropism for human epithelium of skin and mucus membrane. • Non-enveloped, size:50-55nm with icosahedral capsids composed of 72 capsomeres.

Viral Genome of HPV • HPV consistes of doubble stranded circular DNA of

7900-8000 bp. • It consists of: I. Early region[E] II. Late region[L] III. Non-coding regulatory protiens

MOLECULAR MECHANISM

PATHOGENESIS

TYPES

Sq.cell carcinoma

Adenocarcino

Adenosqamous

Neuroendocrin e

PREVALANCE • Cervical cancer is the commonest cause of death among

women in develoing country • WORLDWDE- HPV is asso.with 50,000 new cases of CC & 250,000 asso.with cervical cancer death. • every year in INDIA 1,22,844 women are diagnosed with cervical cancer & 67,477 dies from it,. • In MAHARASTRA high risk of HPV was asso. With low

education,early age at first sexual intercourse. •

RISK FACTOR • Sexual contact

A women has higher risk of developing cervical cancer If she —  Has had multiple sexual partner .  Having sexual relation before age 18yr Unprotected sex Smoking  Family histroy Weakened immune systeam.

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TREATMENT • Treament for cervical cancer depends upon the stage of

the cancer. • Treatments include: Surgery-Hysterectomy, Cervicectomy, Cryosurgery and Lymph node dissection Chemotherapy Radiation therapy

PREVENTION • Vaccination against HPV- recommended for all boys and

girls by age 11-12 years,as well as young men and women upto 26 years. FDA licensed vaccines:1] Nine valent vaccine(Gardasil) 2] Bivalent vaccine(Cervarix) • Barrier methods of contraception can block sexual transmission , thus prevent anogenital HPV infections. • Avoid multiple sexual partners.

CONCLUSION • Lack of knowledge and awareness of HPV Infection ,risk • •

• • • • • •

factor . PREVENTIONHPV education Screening for early detection Encourage follow up session VACCINATIONNational programs –health promotion campaign on local & national basis. Lower cost or free vaccination. Develop public heath national screening programme