Forebrain 1: Telencephalo n Bill Truitt Office: MS 513 278.9050
[email protected]
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Forebrain 1: Telencephalon Forebrain (prosencephalon) =
??? + ??? Telencephalon Largest Brain division Major Components:
??? structures of the Telencephalon e.g. Basal Forebrain, Amygdala, Basal Ganglia,
Striatum
??? tracks e.g. corona radiata, internal capsule
???? e.g. primary motor cortex, Broca’s area…
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Forebrain 1: Telencephalon Forebrain (prosencephalon) =
telencephalon + diencephalon Telencephalon Largest Brain division Major Components: Subcortical structures of the
Telencephalon
e.g. Basal Forebrain, Amygdala, Basal Ganglia,
Striatum
White matter tracks e.g. corona radiata, internal capsule
Cerebral Cortex
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Overview Cortical organization (lamina) Cell types/ Layers/ Connections vertical organization Types of cortex Brodmann’s Areas Cytoarchitecture and relation to function Key Brodmann’s Areas Major White Matter tracts of the Cerebral
cortex
Internal Capsule 4
Descriptive Anatomy to function Histological staining (Cell (overview) Bodies) Discovered ??? arrangement of
the cortex ??? are defined by cell type, size and density
Broadman’s areas Regions of the cortex have unique ??? Gave numbers to each of these ??? (Broadman’s areas) Broadman’s areas and cortical
function
Laminar layers have ???
correlates Size of these layers are related
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Descriptive Anatomy to function Histological staining (Cell (overview) Bodies) Discovered laminar
arrangement of the cortex Lamina are defined by cell type, size and density Broadman’s areas Regions of the cortex have unique laminar patterns Gave numbers to each of these laminar patterns (Broadman’s areas) Broadman’s areas and cortical
function
Laminar layers have functional
correlates
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Cerebral Cortex – the Basic Ins and Outs Afferent fibers
enter ???
??? process the
afferent information
??? fibers convey
the processed information to another site
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Cerebral Cortex – the Basic Ins and Outs Afferent fibers
enter cortex
Local circuits
process the afferent information
Efferent fibers
convey the processed information to another site
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Cell Types and laminar locations: Local Circuit (interneurons) Local circuit neurons – AKA
Interneurons
interneurons, intrinsic neurons
???
???
??? do not leave the immediate
region of cell body, can cross into different laminar layers Inhibitory, contain ??? (1 exception)
Function – ??? Formulate rhythms, coordinate outputs Interneurons classified by ??? ??? - Laver IV ??? (have spines) Receptive field II – IV Excitatory (Glutamate) ???(lack spines) Receptive field mainly IV
??? –Layers III And V Receptive field (all layers) ???– Layer III
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output Aspiny
Spiny
???
Cell Types and laminar locations: Local Circuit (interneurons) Local circuit neurons – AKA
Interneurons
interneurons, intrinsic neurons Axons do not leave the
immediate region of cell body, can cross into different laminar layers Inhibitory, contain GABA (1 exception)
Chandelie r cells
Stellate (granule) cells
Function – regulate inputs to
and from pyramidal cells (cortical output cells)
Formulate rhythms, coordinate
outputs
Interneurons classified by
morphology
Stellate (granule) - Laver IV Spiny (have spines)
Receptive field II – IV Excitatory (Glutamate)
Aspiny (lack spines) Receptive field mainly IV
Basket –Layers III And V Receptive field (all layers)
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output Aspiny
Spiny
Basket cells
Cell Types and laminar locations: Pyramidal (output neurons) Pyramidal cells: most inputs
Pyramidal cells size by loci Layer VI – ???; layer II&III – ???; layer V – ??? Layer VI pyramidal cells
inputs
???
Inputs - Dendrites span layers ??? Outputs – ???
Layer II & III pyramidal cells Inputs – Dendrites span layers ??? Outputs – ??? Layer V pyramidal cells
inputs
???
???
??? (largest pyramidal neurons)
primary ??? (upper motor neurons) Inputs – ??? Outputs –???, ???, ???, ??? 11
Corticocortical terminas
output
output output
Cell Types and laminar locations: Pyramidal (output neurons) Pyramidal cells: most Pyramidal cells size by loci Layer VI – small; layer II&III – small to medium; layer V – Large Layer VI pyramidal cells
inputs
inputs
Inputs - Dendrites span layers IV –
Medium
VI Outputs – Thalamus, cortex, claustrum
Layer II & III pyramidal cells Inputs – Dendrites span layers I – IV Outputs – Cortex opposite hemisphere (callosal) Layer V pyramidal cells Betz cells (largest pyramidal
neurons) primary motor cortex (upper motor neurons) 12
inputs
large
smal l Corticocortical terminas
output
output output
???? organization of cortex Cortex is arranged
in ??? Run vertically (perpendicular to surface) ~ 1 mm in diameter, containing 300 – 600 cells Neurons in a column
synapse mostly with ??? ??? do connect near by columns
Pia surface
WM
??? is comprised of
billions of columns Cortical columns are
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Vertical organization of cortex Cortex is arranged in
functional columns Run vertically
Pia surface
(perpendicular to surface) ~ 1 mm in diameter, containing 300 – 600 cells
Neurons in a column
synapse mostly with other cells in the column Axon collaterals do connect near by columns
WM
Cortex is comprised
of billions of columns Cortical columns are quasi-independent processing units that
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Radial Glia and formation of ???? marginal zone cortical place
corticocorti cal bundles (CC) thalamic radiation (TR) nucleus basalis (NB) monoamine centers
subplate zone
Radial Glia Migration neuron
intermedi ate zone
ventricula r zone 15
Radial Glia and formation of Functional Columns marginal zone cortical place
corticocorti cal bundles (CC) thalamic radiation (TR) nucleus basalis (NB) monoamine centers
subplate zone
Radial Glia Migration neuron
intermedi ate zone
ventricula r zone 16
Columns and receptive fields Each column is a ??? ??? specificity for each
column i.e. a column may receive sensory input from rapidly adapting mechanoreceptor receptive field from the middle left fingertip (via spinal and thalamic pathways) Adjacent columns may
pertain to ??? from the same region i.e. a column adjacent to
RA = rapidly adapting receptive field i.e. epicritic(small filled circles) SA = slowly adapting receptive field i.e. protopathic (large open circles)
the one mentioned above may receive input fromcontains the ??? Column slowly adapting
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Columns and receptive fields Each column is a single receptive field – single modality Regional functional
specificity for each column i.e. a column may receive sensory input from rapidly adapting mechanoreceptor receptive field from the middle left fingertip (via spinal and thalamic pathways) Adjacent columns may
pertain to different modality from the same region
i.e. a column adjacent to
RA = rapidly adapting receptive field i.e. epicritic(small filled circles) SA = slowly adapting receptive field i.e. protopathic (large open circles)
the one mentioned above may receive input from Column contains the microcircuitry for representing a single slowly adapting receptive field mechanoreceptor receptive
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???
Laminar organization: AfferentConnections
Glutamatergic Predominantly terminate in layer IV ???
???
Glutamatergic axons from
cortical regions outside of local circuit Terminate in layers I – VI, within a single cortical column
???
Origins: Non-specific
thalamic nuclei, basal nucleus of Meynert, Brain stem nuclei Substrates: glutamatergic, cholinergic, serotonergic, noradrogergic Terminates in layers I – VI, across multiple cortical columns
Haines
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Laminar organization: AfferentConnections Thalamocortical afferents
Glutamatergic Predominantly terminate in layer IV (thalamo-
receptive layer) Corticocortical afferents
Glutamatergic axons from
cortical regions outside of local circuit Terminate in layers I – VI, within a single cortical column
Diffuse cortical afferents
Origins: Non-specific
thalamic nuclei, basal nucleus of Meynert, Brain stem nuclei Substrates: glutamatergic,
Haines
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Laminar EfferentOrganization: Corticofugal/Corticothalamic Efferents Corticofugal Efferents Pyramidal cells of ??? ??? targets i.e. Corticospinal,
corticostriate, corticobulbar, cortico-tectal, corticopontine, etc.
Corticothalamic Efferents ??? cells mainly in
layer ???
Corticothalamic
Haines
Laminar EfferentOrganization: Corticofugal/Corticothalamic Efferents Corticofugal Efferents Pyramidal cells of layer V Non-cortical
(subcortical) targets i.e. Corticospinal, corticostriate, corticobulbar, cortico-tectal, corticopontine, etc.
Corticothalamic Efferents Pyramidals cells
mainly in layer VI and V
Corticothalamic
Haines
Laminar EfferentOrganization: Corticocortical Efferents Pyramidals cells mostly
located in layers ??? Axons project to distal cortical targets not ??? Terminate in layers ??? of a single cortical column Cortical Targets in contralateral hemisphere are ??? connections Tend to project to homologous
area in opposite hemisphere
Cortical targets within same
hemisphere (ipsilateral)
Haines
Cortico-cortical: callosal & association
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Laminar EfferentOrganization: Corticocortical Efferents Pyramidals cells mostly
located in layers II & II Axons project to distal cortical targets (not local projections) Terminate in layers I – VI of a single cortical column Cortical Targets in contralateral hemisphere are Collosal (commissural) connections Tend to project to homologous
area in opposite hemisphere
Cortical targets within same
hemisphere (ipsilateral) are Association Connections
Haines
Cortico-cortical: callosal & association
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Major cortical connection from a gyrus
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Major cortical connection from a gyrus
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Cerebral Cortex Contains Regions Differing in Phylogenetic Development •??? (95%) • 6 layers • 1o sensory/motor, association area •Cognition, reasoning, perception, speech/language
•??? (5%) •??? •Up to 3 layers •Memory (e.g., hippocampus)
6 3
•??? • 4-5 layers • Smell/Emotion (e.g., olfactory ctx)
•??? function
Martin
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Cerebral Cortex Contains Regions Differing in Phylogenetic Development •Neocortex (95%) • 6 layers • 1o sensory/motor, association area •Cognition, reasoning, perception, speech/language
•Allocortex (5%) •Archicortex •Up to 3 layers •Memory (e.g., hippocampus)
6 3
•Paleocortex • 4-5 layers • Smell/Emotion (e.g., olfactory ctx)
•Limbic function
Martin
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Allocortex
Martin
6 layers
< 6 layers
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Allocortex
Martin
??? layers
< ??? layers
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Hippocampus – Allocortex structure R superior
Coronal section
L
Midsagitt al plane
inferi or
Parahippocampal gyrus of medial temporal lobe 31
???? – Allocortex structure
superior
Coronal section
R
L
Midsagitt al plane
inferi or
Parahippocampal gyrus of medial temporal lobe 32
Types of Neocortex: Homo- v Heterotypical Cortex ??? Cortex Each layer has about the same thickness Representativ e of ??? cortex ??? Cortex Aberrant
thickness of one or more layers Specific layers are over or under represented
Haines
IV: prominent V: narrow
V: prominent IV: narrow 33
Types of Neocortex: Homo- v Heterotypical Cortex Homotypical
Cortex
Each layer has
about the same thickness Representativ e of association cortex Heterotypical
Cortex
Aberrant
thickness of one or more layers Specific layers are over or
Haines
IV: prominent V: narrow
V: prominent IV: narrow 34
Cortical Cytoarchitecture: Brodann’s Areas Cortical divisions baseddiffering ? ??, defined by patterns of Nissl staining
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Cortical Cytoarchitecture: Brodann’s Areas Cortical divisions baseddiffering cytoarchitecture , defined by patterns of Nissl staining
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Brodmann's Areas •1ocortex
•2ocortex (sensory, motor)
•Unimodal 37
Brodmann's Areas •1ocortex
•2ocortex (sensory, motor)
•Unimodal 38
Brodmann's Areas •Higher motor cortex
•Association cortex
•Multi-modal
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Brodmann's Areas •Higher motor cortex
•Association cortex
•Multi-modal
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Brodmann’s Area (BA) of Cerebral Cortex
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Organization within Brodmann’s Areas Sensory and Motor homunculi ??? within primary cortex map body (M1, S1) ??? may represent different modalities from the same area (i.e. same
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Organization within Brodmann’s Areas Sensory and Motor homunculi Cortical columns within primary cortex map body (M1, S1) Adjacent cortical columns may represent different modalities from the same area (i.e. same receptive field on skin)
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Functional hemisheric ???of Higher cortical function •Speech: ??? hemisphere •Aphasia: speech disorders with ??? lesion
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Functional hemisheric asymmetry of Higher cortical function •Speech: left hemisphere •Aphasia: speech disorders with Left Hemisphere lesion (Frontal or Temporal/Parietal cortex)
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Right Parietal Association Cortex
???? Right (nondominant) parietal lesion ??? syndrome: unaware of objects/events in left visual field ??? – inability to draw maps – remember how they got to work ??? – inability to duplicate spatial relations of individual parts of models ??? – lack of •Neglect syndrome:with RH (parietal) lesion humor,
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Right Parietal Association Cortex Space and Attention Right (nondominant) parietal lesion Neglect syndrome: unaware of objects/events in left visual field Spatial surroundings deficits – inability to draw maps – remember how they got to work Constructional apraxia – inability to duplicate spatial relations of individual parts of models •Neglect syndrome:with RH (parietal) lesion Loss of affect –
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Major White Matter Tracts of Cerebral Cortex
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associationconnections: •Association connections •??? projections •Same lobe: adjacent regions •??? •??? •Different lobes •??? • WM tract interconnecting limbic lobe •??? •??? •Important in speech processing 49
associationconnections: •Association connections •Ipsilateral projections •Same lobe: adjacent regions •1o& 2o sensory cortex •Association regions •Different lobes •Cingulum (deep to cing. gyrus) • WM tract interconnecting limbic lobe •Uncinate fasciculus •Arcuate fasciculus •Important in speech processing 50
Digital Anatomist:Arcuate Fasciculus – Language coordination
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Digital Anatomist:Arcuate Fasciculus – Language coordination
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Internal Capsule Internal capsule
???
???
axial
???
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Internal Capsule Internal capsule
Thalamolenticular
Sublenticular
axial
Retrolenticular 54
InternalCapsule: Genu and Posterior limb descending projections
Thalamolenticular
axial
InternalCapsule: Genu and Posterior limb descending projections
Thalamolenticular
axial
Digital Anatomist: Corticobulbar/spinal
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Digital Anatomist: Corticobulbar/spinal
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InternalCapsule: Genu and Posterior limb ascending projections (Superior Thalamic Radiation)
Thalamolenticular
axial
InternalCapsule: Genu and Posterior limb ascending projections (Superior Thalamic Radiation)
Thalamolenticular
axial
InternalCapsule and Auditory radiations
Sublenticular
axial
Digital Anatomist: Somatosensory radiations
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Digital Anatomist: Somatosensory radiations
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Digital Anatomist: Auditory radiations
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Digital Anatomist: Auditory radiations
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InternalCapsule and Optic radiations
axial
Retrolenticular 66
InternalCapsule and Optic radiations
axial
Retrolenticular 67
Digital Anatomist: Optic radiations
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Digital Anatomist: Optic radiations
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END
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