Carbohydrates
(‘Hydrates of carbon') or saccharides (Greek meaning "sugar") MOST abundant of the biomolecules which also include proteins , fats and nucleic acids Simple organic compounds that are aldehydes or ketones with many hydroxyl groups added, usually one on each carbon atom that is not part of the aldehyde or ketone functional group
The basic carbohydrate unit is called Monosaccharide The general formula of an unmodified monosaccharide is (C·H2O)n, where n is any number of three or greater
Sources
Foods that are high in carbohydrates include breads, pastas, beans, potatoes, bran, rice and cereals.
Classification :
The most useful Classification Scheme divides the carbohydrates into groups according to the number of individual simple sugar units
Monosaccharide Disaccharides Polysaccharides
Number of Carbons Functional Groups
Structural Representation of Carbohydrates
Open Chain Structure
Hemi-acetal Structure
Haworth Structure
Open Chain Structure
Long Straight chain form of carbohydrates
Hemi-acetal Structure
The 1st Carbon in glucose condenses with the –OH group of the 5th Carbon to form a ring
Haworth Structure
Presence of a Pyranose Ring
Physical Properties
Stereoisomerism : Same structural formula but differ in spatial configuration With respect to the Penultimate Carbon atom glucose has 2 stereoisomers D-glucose and L-glucose
D-Glucose
L-Glucose
Optical Activity : Rotation of Plane polarized light and (+)glucose or (–)glucose respectively
Diastereo Isomers : Configural changes with regard to the C2 , C3 or C4 in glucose. Eg : Mannose , Galactose
Anomerism : Spatial configuration with respect to the first carbon atom in Aldoses and the second in Ketoses α-glucose has specific rotation of 112 and ß-glucose has a rotation of 19.
Importance – In glucose estimation by GOD/POD , the enzyme acts preferentially on the ß form. Hence fresh glucose solutions give lower values.
Chemical Properties
Ozazone formation with phenlyhydrazine Benedicts test Oxidation Reduction to Alcohols
Digestion of Carbohydrates
Polysaccharides in the mouth are broken through the introduction of amylase, a digestive enzyme in saliva. The high acid content of the stomach inhibits amylase activity, so carbohydrate digestion is suspended in the stomach. Pancreatic amylase is secreted by the pancreas into the duodenum and works with other enzymes to complete the breakdown of carbohydrate into a monosaccharide Is then absorbed into the surrounding capillaries of the villi.
Nutrition
Carbohydrates are not essential nutrients The body can obtain all its energy from protein and fats Carbohydrates contain 3.75 Kilocalories An essential diet contains between 40-65% of dietary energy from carbohydrates
Glycemic Index
A measure of the effects of carbohydrates on blood glucose levels. Carbohydrates that break down rapidly have a high GI; Those that break down slowly, releasing glucose gradually into the bloodstream, have a low GI A lower glycemic response is often thought to equate to a lower insulin demand, better long-term blood glucose control and a reduction in blood lipids.
Classification
GI range
Examples
Low GI
>55 %
Moderate GI
55 – 69 %
High GI
70 and above
most fruit and vegetables, grainy breads, pulses wheat bread, whole wheat products, brown rice, orange corn flakes, baked potato, white bread
Functions of Carbohydrates
Carbohydrates spare protein from being used up as an energy source. If there are not enough carbohydrates, then large amounts of fat are used for energy. The body is not able to handle this large amount so quickly, so it accumulates ketone bodies Carbohydrate is necessary for the regulation of nerve tissue and is the source of energy for the brain. Some carbohydrates are high in fibre, which helps prevent constipation Structural components