Bionetek Technology Comparative Analysis Chart

Technology Comparison Analysis

Test Conventional  Angiogram

Occlusive CAD  Diagnostic  Accuracy

Equipment  Cost

Risk

Time

98%

Highest

High

8 hrs

CARDx ECD   (12‐lead CCG)

90~94%

Medium Low

None

10 min

64-Slice CCTA

Sensitivity 91~99% Specificity 64~91%

High

Moderate

60 min

Stress  Thallium  SPECT

S i i i   8 %  Sensitivity 80~90% Specificity 70~75%

High

Stress Echo‐ cardiogram

80% (27% false  positive if  hypertensive)

Medium

Moderate

Echo‐ cardiogram

75%

Medium Low

None

Stress ECG

50~70%

Low

Moderate

ECG

40~50%

Lowest

None

Moderate

4 hrs

Advantages ˆ   Clinical standard for CAD

Limitations ˆ   Invasive, expensive, high risk, and  time consuming

ˆ   The only accurate, fast, and non‐ invasive technology for early detection of  ˆ   Only available for 3D localization of  the approximate ischemic area(s) of  CAD, ischemia, microvascular  involved coronary arteries dysfunction, &  differentiating heart  dsyfunctions ˆ   High calcium score ˆ   A useful way of screening for CAD ˆ   Motion artifact ˆ   Allergic reaction due to IV contrast  ˆ   Safer and faster than conventional  injection angiogram ˆ   Kidney diseases or severe diabetes ˆ   M j i   ffraction i ˆ   Most accurate  ffor ejection

ˆ   Some risk with exercise ˆ   Requires IV radio‐isotope injection ˆ   Expensive

ˆ   Best for ischemia detection ˆ   Evaluates wall motion & heart under  ˆ   Only 80% accurate stress 30~40 min  ˆ   Risk of AMI (technically  ˆ   Non‐invasive demanding) ˆ   Good for measuring valvular ejection  ˆ   Must be ischemic to show  abnormalities fraction and left ventricular function ˆ   Best for valvular, congenital, and wall  ˆ   Only 75% accurate for CAD, good  motion 15 min images cannot be obtained in 5~15% of  ˆ   Non‐invasive patients ˆ No risks ˆ   Detects perfusion deficit ˆ   Not recommended if abnormal EKG 30~40 min ˆ   Only 42% accurate on women; 33%  ˆ   Non‐invasive false positives, 25% false negatives ˆ   Low accuracy, not always specific,  ˆ   Inexpensive insensitive to ischemia ˆ   No risk ˆ   Not always specific 10 min ˆ Fast ˆ Insensitive to ischemia ˆ Non-invasive www.bionetek.com