Bio2000 Repair
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Introduction: DNA Repair and Carcinogenesis
A Simple-minded Working Hypothesis Functional Genome Aging
•High Fidelity of DNA Replication •DNA Repair System
Genome Stability Decline
Accumulations of Mutations in Oncogenes, Tumor Suppressor Genes, Signal Transduction Components
Cancer Formation
"Mutator Gene" Defectiveness
Mismatch repair (MMR) Nucleotide excision repair (NER) Base excision repair (BER)
Introduction: DNA Repair and Carcinogenesis
In 1993, Fishel et al reported that the human mutator gene hMSH2 is associated with hereditary nonpolyposis colon cancer (HNPCC). The mismatch repair pathway (hMSH2, hMLH1, hPMS1 and hPMS2) keeps the stability of chromosome microsaterlite repeats (e. g. GTn)
Introduction: DNA Repair and Carcinogenesis
Introduction: DNA Repair and Carcinogenesis
The Nucleotide Excision Repair Pathway
A Simple-minded Working Hypothesis Functional Genome Aging
•High Fidelity of DNA Replication •DNA Repair System
Genome Stability Decline
Accumulations of Mutations in Oncogenes, Tumor Suppressor Genes, Signal Transduction Components
Cancer Formation
"Mutator Gene" Defectiveness
Mismatch repair (MMR) Nucleotide excision repair (NER) Base excision repair (BER)
Introduction: DNA Repair and Carcinogenesis
In 1993, Fishel et al reported that the human mutator gene hMSH2 is associated with hereditary nonpolyposis colon cancer (HNPCC). The mismatch repair pathway (hMSH2, hMLH1, hPMS1 and hPMS2) keeps the stability of chromosome microsaterlite repeats (e. g. GTn)
Introduction: DNA Repair and Carcinogenesis
Introduction: DNA Repair and Carcinogenesis
The Nucleotide Excision Repair Pathway
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