Annales Sciences

Gly-Lys : A Gly-Glu-Lys : B

Glu

Asp

Lys

(CH2) 2-COOH

CH2 -COOH

(CH2) 4-NH2

Gly

Ala CH3

R

B A

2 1

1 = PH

13 = PH

B

6 = Gly

3-1

PHi

(

3 3

Ala-Asp-Ala-Gly-Glu-Asp

ASP NH2

Gly 2-

13 = PH

PH PH

34-

%20

%15

H H H HOOC - CH2 - C - COOH , NH2 - (CH2 )4- C - COOH , H2N - C - COOH NH2 NH2 CH2 Asp Lys Ala 1

2 105 HCL

((1)

(1 )

) Hcl 2

HIS

THR

LEU

ALa

1 H2N NH2

R2 R1 H R2 ... H2N - CH - C - CH - CO - - NH2 - CH - COOH ( O R1 H (

1)(H2N - CH - C - N - NH2 + ...) O

1) H2N NH2

H2N - CH - COOH O

2 1 2

2 OH R = - CH2

THR R = - CH

N NH

CH3

CH3 Leu R = - CH2 - CH

(Ala) R = - CH3

CH3

CH

pH

3

pH pH

1

pH Ala = 6,02 His = 7,58 Leu = 5,98 (LTC)

THR = 5,65 2

T

1 3

T 1

1 2

LTC

2

2 LTC

ARN m ARN m

ADN

Gly - Arg Gly - Glu Gly - Glu - Arg

H = GLY , (CH2)2 COOH = GLU

R

NH NH2 - C - NH - (CH2)3 = Arg

1 = PH 13 = PH

CMH

NH2

CH2

CO

NH

CH

CO

NH

CH

(CH2)2

(CH2)

COOH

NH2

COOH

=B

PH =1

PH = 13 = gly

PHi = 6 Gly 6

PH gly ]

[

-

Gly

-

Lys

PH = 6 -

+

Gly

Ala-Asp

A a-Gly

A a-Asp-CooCoo-

Gly PHi = PH=6

Lys

Gly-Asp PH = COOH Ala-Asp

COOH

A a - Gly - COO-

Ala -Gly

1 COOH

Glu - Asp - COO-

3

Glu -Asp

COO- COO-

3 PH=13

PH .4 PH=13

A a-Gly -1

A a-Asp -2

Glu-Asp -3

PH=

Ala-Gly

PH=6

A a-Asp -2 PHi

Gly-Asp -3 Gly A a

1

Ala Asp Lys

HCl

1

2 2

His Ala 1

His Ala 2 Ala His

C

H2N - CH - C - NH - CH - COOH + H2O CH

CH2

3

Ph

Ala Phi

PH

is

Phi

is Ala PH 7,5

PH

,

1 1 LT LT

2 3 LT

LTC

LTC CMH

(LTC + A9)

LTC CD8

2

H

2

2 2

2 2

OH

2

N

N NH2 - C - NH - (CH2)3 - C - COOH 2

NH2 - C - CO - NH - C - CO - NH - C - COOH (CH2) NH2 - C - NH - (CH2)3 OH

2

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