A flare to care A Case Presentation
AI female GENERALIZED 27 y/o single Solsona INC
BODY WEAKNESS th 6 admission
intermittent fever with diaphoresis Generalized body weakness Dizziness Mycophenolate mofetil 500 mg BID Knee pain brusing30 mg OD Easy Prednisone malar Caltraterash plus 500 mg OD amennorhea FeSO4 and folic acid OD, dosage unrecalled alopecia
Diagnosed case of SLE 2013
INTERIM
2 weeks PTA
Symptoms were recurrent Managed by rest & adherence to medications Symptoms non-tolerable: Consult
Generalized body weakness Managed by rest but still felt weak No consultations
4 days PTA
Same symptoms still present Follow-up check-up at the OPD CBC – low Hgb Refused to be admitted
Symptoms have not subsided yet Few hours Consulted Admitted PTA
Past Medical History (-) measles Childhood (-) chicken pox (-) mumps
(+) hypertension managed with Amlodipine 10mg OD highest BP 210/110 (-) diabetes mellitus, liver disease, asthma
Medical
Menarche: 14 y/o Obstetrics regular til 18 y/o without dysmenorrhea
Surgical
Psychiatric
Allergies
(-) history of surgeries (-) accidents (-) falls
denied any history of psychiatric illness
(-) known allergies to food or medicines
Heredofamilial (+) hypertension (-) kidney disease (-) stroke (-) diabetes mellitus (-) thyroid & liver disease (-) cancer (-) congenital disease (-) asthma (-) SLE Infectious (-) TB (-) Hepatitis
Family History
Personal History College Undergraduate
Lives with her parents and 5 siblings – with good interpersonal relationship Currently manages their own sari-sari store Non-smoker Non alcoholic beverage drinker Source of Stress prior to and during appearance of symptoms – OJT (kitchen staff)
Review of Systems General: + weight loss , no fever Skin: no lumps, no sores, + change in color Head: no headache, + dizziness, + lightheadedness Eyes: + blurring of vision, no pain, no redness, no excessive tearing Ears: no hearing loss, no tinnitus, no vertigo, no earaches, no discharges Nose and Sinuses: no colds, no nasal stuffiness, no discharge, no itching, no epistaxis Mouth/Throat: no bleeding gums, no dentures, no sore tongue, dry mouth, no sore throat, no hoarseness; (+) oral ulcers Neck: no swollen glands, no pain, no stiffness
Review of Systems Breast: no lumps, no pain, no discharge Cardiovascular: no chest pain, no palpitations GI: no dysphagia, no heartburn, no poor appetite, no nausea, no vomiting, no abdominal pain, no pain on defecation, no diarrhea, no constipation Peripheral Vascular: no pain, no leg cramps, no swelling Urinary: no frequency, no urgency, no polyuria, no nocturia, no pain, no incontinence, no hesitancy, no dribbling, no hematuria, no flank pain
Review of Systems Musculoskeletal: no muscle pain, + joint pain, no stiffness, no swelling, + paresthesia Psychiatric: no nervousness, no tension, no depression, no memory change Neurologic: no mood changes, no slurring of speech, no dizziness, no headache, no paralysis, no numbness Hematologic: + anemia, + easy bruising, no bleeding, (+) previous blood transfusion Endocrine: No heat intolerance, no cold intolerance, no polyphagia, no polyuria, no polydipsia, no increased sweating
Physical Examination General Survey: Awake, coherent, not in CP distress Vital signs: BP = 160/100 mmHg T = 37.3 oC HR = 117 bpm RR = 18 cpm O2 saturation = 99%, room air
Anthropometrics: Height: 148 cm Weight: 45 kg BMI: 20.5 – Normal
Physical Examination
Skin, Nails: Fair complexion, with discoid rash on the extensor surface of both arms, hematoma on left anterior forearm, dry, smooth, with good skin turgor, pale nail beds, palmar pallor, no pitting nails, no clubbing of digits, CR of < 2 secs.
Physical Examination
HEENT: Head: (+) Non-scarring alopecia, no mass, no tenderness Eyes: Pale palpebral conjunctiva, anicteric sclera, no hemorrhage Ears: No auricular tenderness; acuity good to whisper voice Nose: Patent, pink nasal mucosa, septum in midline, no sinus tenderness Mouth and throat: Dry pinkish lips; pinkish gums and buccal mucosa; uvula in midline; tongue midline without fasciculation, no mouth sores/ulcers, no gum bleeding, unenlarged tonsils, non-hyperemic, no exudates
Physical Examination Neck: no visible pulsations on carotid artery, no neck vein distention, no CLAD, non-enlarged thyroid glands no tenderness; no carotid thrills and bruits Back, Thorax, Lungs: Symmetrical chest expansion. Resonant on both lungs. Breath sounds heard on all lung fields. No crackles, no wheezes noted. Cardiovascular: Adynamic precordium, no heaves, no thrills, PMI at 5th ICS MCL. Tachycardic, regular rhythm. No murmurs heard. Abdomen: Globular, no visible pulsations, no visible blood vessels, no bulging flanks, normoactive bowel sounds, tympanitic, no palpable masses, soft non-tender, no CVA tenderness.
Physical Examination
Peripheral Vascular: radial, brachial, popliteal, dorsalis pedis pulses all normal (+2) Musculoskeletal: Gait: normal Arms: normal ROM Limbs: normal ROM Spine: No obvious deformities
Physical Examination Neurological Examination GCS: E4V5M6 (15) Mental Status: Alert, cooperative Cerebrum: oriented to time, place and person Cranial nerves: CN I = not assessed CN II = pupils equally round reactive to light 2 mm, (+) ROR, intact visual acuity, visual field full CN III, IV, VI = EOM intact, no nystagmus CN V = intact sensation, motor not tested CN VII = no facial asymmetries, taste not assessed CN VIII = intact gross hearing CN IX, X = able to swallow without difficulty CN XI = shrugs shoulder, turn head side to side CN XII = tongue midline, no atrophy
Physical Examination
Motor: 5/5 on all extremities Sensory: 5/5 on all extremities Reflexes: not assessed
Age Gender: Female Environmental Triggers
Salient Features
Clinical Manifestations
SYSTEMIC LUPUS ERYTHEMATOSUS, ACTIVE
Algorithm in the Diagnosis of SLE
Skin
Systemic Lupus International Collaborating Clinic (SLICC) Criteria for Classification of SLE
(Acute, Subacute, Chronic Cutaneous LE)
Oral Ulcer
Alopecia
Synovitis
Renal (Prot/Cr ≥0.5, RBC casts, Biopsy)
Neurologic
Hemolytic anemia
Leukopenia (<4000) or Lymphopenia (<1000) Thrombocytopenia (<100,000)
In flare but not in despair ABELLON ▪ CASTILLO ▪EROJO ▪ LABASAN ▪ LORENZO ▪ ROLDAN