7. Glycolysis And Tca Cycle - Compartmentation

GLYCOLYSIS & TCA CYCLECOMPARTMENTATION

H H OH H HOCH2 ---C---C---C---C--CHO OH OH H OH

GLUCOSE

ATP

H H OH H P-OCH2---C---C---C---C--CHO OH OH H OH Glucose-6-P H H OH P-OCH2---C---C---C---CO--CH2OH OH OH H Fructose-6- P

ADP

ATP

H H OH P-OCH2 ---C---C---C---CO--CH2OP OH OH H Fructose-1,6-bis-P P-OCH2 COCH OH 2

ADP

Glycerone-3-P

(Di-OH-acetone- P) P-OCH2 CH(OH)CHO

3-P-Glyceraldehyde

G L Y C O L Y S I S

2NAD+ 2Pi

P-OCH2CH(OH)COO- P

1,3-bis-P-Glycerate P -OCH2 CH(OH)COO

2ADP

_

_ P-OCH2CH(O- P)COO

2-P-Glycerate

CH2 =C(O-P) COO

CH3COCOO

_

2ADP

_

PYRUVATE DEHYDROGENASE

2HSCoA 2NAD+

PYRUVATE CH3CO.SCoA

ACETYL-CoA -OOCCOCH COO2

2H2O

Oxaloacetate

CH2COOC(OH)COOCH COO-

Malate

-OOCCH=CHCOO-

Fumarate

-OOCCH CH COO2 2

Succinate

2CO2 2NADH+2H+ 2HSCoA

Citrate

2

-OOCCH(OH)CH COO2

2H2O 2ATP

PYRUVATE

C Y C L E

+

2 ATP

3-P-Glycerate

P-enolpyruvate

T C A

2 NADH+2H

CH(OH)COOCHCOO- Isocitrate CH COO2

-OOCCOCH CH COO2 2

+ 2NAD+ 2NADH+2H 2H2O 2NAD+

2-Oxoglutarate 2UQ 2NAD+

-OOCCH CH CO.SCoA 2 2

Succinyl-CoA

2Pi 2GDP

2CO2 2NADH+2H+ 2UQH2 2CO2 2NADH+2H+ 2HSCoA 2GTP

Anaerobic Oxidation of Glucose C6H12O6 +10NAD+ +2UQ +2ADP +2Pi +2GDP + 2Pi + 4H2O

6CO2 +10NADH+10H++2UQH2+2ATP+2GTP