1. The Hub Of Metabolism

THE HUB OF METABOLISM

Fa

tty

Ac id

An ab

ty A

c id

ism ol

Fat

PYRUVATE

Cat abo lism

Ketone Bodies

ACETYL-CoA

OH-Methyl glutaryl-CoA

ol an e h Et erin ine ine S yste C stathion Cy ne C ys t e i E N ALA IN Valine LACTATE Isole ucine Lys ine Pyrimidines

OXALOACETATE MALATE

Carotenoids

CITRATE

FUMARATE

Glyoxylate

Cholesterol Steroids

1.3.5.1

ISOCITRATE

Heme

SUCCINATE SUCCINYL-CoA

2-OXOGLUTARATE

M I TO

Leucine Leucine Aspartate Tyrosine Aspartate Urea Cycle 4-NH2-Butanoate Pyrimidines Threonine Odd-C Fatty Acids 4-NH2-Butanoate Glutamate

C HO N D RIA

Most of the anabolic pathways start and the catabolic pathways end in the "backbone" of metabolism - Glycolysis and the TCA Cycle. This map shows some of the many pathways which cluster around pyruvate, acetyl-CoA and the TCA Cycle.

Designed by Donald Nicholson

c 2002 IUBMB